1,844 research outputs found

    Where to Expand Green Infrastructure to Support Equitable Climate Change Adaptation in the City of Toronto?

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    Green Infrastructure (GI) is a potential tool to help cities adapt to climate change. In particular, GI can help moderate high summer temperatures and reduce urban flooding, both of which are expected to become more common with on-going climate change. However, GI is not evenly distributed in many cities suggesting that some neighborhoods are more vulnerable to climate change impacts. Additionally, marginalized communities often lack the resources needed to reduce existing vulnerabilities. This study explores the question: where should GI initiatives be focused to support equitable climate change adaptation in the City of Toronto (Ontario, Canada)? We address this question by applying a GI Equity Index that includes built environment and socio-economic factors to identify neighborhoods’ level of need for GI to support climate change adaptation. The spatial location of high need neighborhoods, and their particular characteristics, are examined. Our results highlighted the spatial clustering of very high and low need neighborhoods in Toronto. Three types of neighborhoods were identified as most in need: (1) those vulnerable due to very limited existing GI, (2) those vulnerable due to socio-economic characteristics, and (3) those that lack GI and have marginalized populations based on socio-economic measures. On the other hand, neighborhoods identified as least in need based on the index were relatively uniform in character: all had abundant tree canopy and residents who were high income, highly educated, and disproportionately white. These results highlight the importance of considering both built environment and social vulnerability to support an equitable distribution of GI for climate change adaptation, and that varied opportunities and challenges exist related to increasing GI in different types of vulnerable neighborhoods

    Association between diabetes, diabetes treatment and risk of developing endometrial cancer.

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    BackgroundA growing body of evidence suggests that diabetes is a risk factor for endometrial cancer incidence. However, most of these studies used case-control study designs and did not adjust for obesity, an established risk factor for endometrial cancer. In addition, few epidemiological studies have examined the association between diabetes treatment and endometrial cancer risk. The objective of this study was to assess the relationships among diabetes, diabetes treatment and endometrial cancer risk in postmenopausal women participating in the Women's Health Initiative (WHI).MethodsA total of 88 107 postmenopausal women aged 50-79 years who were free of cancer and had no hysterectomy at baseline were followed until date of endometrial cancer diagnosis, death, hysterectomy or loss to follow-up, whichever came first. Endometrial cancers were confirmed by central medical record and pathology report review. Multivariate Cox proportional hazards regression models were used to estimate hazard ratios (HRs) (95% confidence interval (CI)) for diagnosis of diabetes and metformin treatment as risk factors for endometrial cancer.ResultsOver a mean of 11 years of follow-up, 1241 endometrial cancers developed. In the primary analysis that focused on prevalent diabetes at enrolment, compared with women without diabetes, women with self-reported diabetes, and the subset of women with treated diabetes, had significantly higher risk of endometrial cancer without adjusting for BMI (HR=1.44, 95% CI: 1.13-1.85 for diabetes, HR=1.57, 95% CI: 1.19-2.07 for treated diabetes). However after adjusting for BMI, the associations between diabetes, diabetes treatment, diabetes duration and the risk of endometrial cancer became non-significant. Elevated risk was noted when considering combining diabetes diagnosed at baseline and during follow-up as time-dependent exposure (HR=1.31, 95% CI: 1.08-1.59) even after adjusting for BMI. No significant association was observed between metformin use and endometrial cancer risk.ConclusionsOur results suggest that the relationship observed in previous research between diabetes and endometrial cancer incidence may be largely confounded by body weight, although some modest independent elevated risk remains

    The Subduction experiment : cruise report R/V Oceanus cruise number 250 legs 1 and 2 subduction 2 mooring deployment and recovery cruise, 25 January-26 February 1992

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    Subduction is the mechanism by which water masses formed in the mixed layer and near the surface of the ocean find their way into the upper thermocline. The subduction process and its underlying mechanisms were studied through a combination of Eulerian and Langrangian measurements of velocity, measurements of tracer distrbutions and hydrographic propertes and modeling. An array of five surface moorings carrying meteorological and oceanographic instrumentation were deployed for a period of two years beginning in June 1991 as part of an Office of Naval Research (ONR) funded Subduction experiment. Three eight month deployments were planned. The initial deployment of five surface moorings took place during the third leg of R/V Oceanus cruise number 240. The moorings were deployed at 18°N 34°W, 18°N 22°W, 25.5°N 29°W, 33°N 22°W and 33°N 34°W. A Vector Averaging Wind Recorder (VAWR) and an Improved Meteorological Recorder (IMET) collected wind speed and wind direction, sea surface temperature, air temperature, short wave radiation, barometric pressure and relative humidity. The IMET also measured precipitation. The moorings were heavily instrumented below the surface with Vector Measuring Current Meters (VMCM) and single point temperature recorders. Expendable bathythermograph (XBT) data were collected and meteorological observations were made while transitting between mooring locations. This report describes the work that took place during R/V Oceanus cruise 250 which was the second scheduled Subduction mooring cruise. During this cruise the first setting of the moorings were recovered and redeployed for a second eight month period. This report includes a description of the instrumentation that was deployed and recovered, has information about the underway measurements (XBT and meteorological observations) that were made including plots of the data and presents a chronology of the cruise events.Funding was provided by the Office of Naval Research under contract N00014-90-J-1490

    Effect of Pt substitution on the electronic structure of AuTe2

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    We report a photoemission and x-ray absorption study on Au1-xPtxTe2 (x = 0 and 0.35) triangular lattice in which superconductivity is induced by Pt substitution for Au. Au 4f and Te 3d core-level spectra of AuTe2 suggests a valence state of Au2+(Te2)2-, which is consistent with its distorted crystal structure with Te-Te dimers and compressed AuTe6 otahedra. On the other hand, valence-band photoemission spectra and pre-edge peaks of Te 3d absorption edge indicate that Au 5d bands are almost fully occupied and that Te 5p holes govern the transport properties and the lattice distortion. The two apparently conflicting pictures can be reconciled by strong Au 5d/Au 6s-Te 5p hybridization. Absence of a core-level energy shift with Pt substitution is inconsistent with the simple rigid band picture for hole doping. The Au 4f core-level spectrum gets slightly narrow with Pt substitution, indicating that the small Au 5d charge modulation in distorted AuTe2 is partially suppressed.Comment: 13 pages, 4 figures, accepted by Physical Review

    Smartphone assessment of knee flexion compared to radiographic standards

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    Purpose—Measuring knee range of motion (ROM) is an important assessment for the outcomes of total knee arthroplasty. Recent technological advances have led to the development and use of accelerometer-based smartphone applications to measure knee ROM. The purpose of this study was to develop, standardize, and validate methods of utilizing smartphone accelerometer technology compared to radiographic standards, visual estimation, and goniometric evaluation. Methods—Participants used visual estimation, a long-arm goniometer, and a smartphone accelerometer to determine range of motion of a cadaveric lower extremity; these results were compared to radiographs taken at the same angles. Results—The optimal smartphone position was determined to be on top of the leg at the distal femur and proximal tibia location. Between methods, it was found that the smartphone and goniometer were comparably reliable in measuring knee flexion (ICC = 0.94; 95% CI: 0.91–0.96). Visual estimation was found to be the least reliable method of measurement. Conclusions—The results suggested that the smartphone accelerometer was non-inferior when compared to the other measurement techniques, demonstrated similar deviations from radiographic standards, and did not appear to be influenced by the person performing the measurements or the girth of the extremit

    High-coverage whole-genome sequencing of the expanded 1000 Genomes Project cohort including 602 trios

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    The 1000 Genomes Project (1kGP) is the largest fully open resource of whole-genome sequencing (WGS) data consented for public distribution without access or use restrictions. The final, phase 3 release of the 1kGP included 2,504 unrelated samples from 26 populations and was based primarily on low-coverage WGS. Here, we present a high-coverage 3,202-sample WGS 1kGP resource, which now includes 602 complete trios, sequenced to a depth of 30X using Illumina. We performed single-nucleotide variant (SNV) and short insertion and deletion (INDEL) discovery and generated a comprehensive set of structural variants (SVs) by integrating multiple analytic methods through a machine learning model. We show gains in sensitivity and precision of variant calls compared to phase 3, especially among rare SNVs as well as INDELs and SVs spanning frequency spectrum. We also generated an improved reference imputation panel, making variants discovered here accessible for association studies

    The subduction experiment : cruise report R/V Knorr : cruise number 138 leg XV : subduction 3 mooring recovery cruise, 13-30 June 1993

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    Subduction is the mechanism by which water masses formed in the mixed layer and near the surface of the ocean find their way into the upper thermocline. The subduction process and its underlying mechanisms were studied though a combination of Eulerian and Langrangian measurements of velocity, measurements of tracer distributions and hydrographic properties and modeling. An array of five surface moorings carrying meteorological and oceanographic instrumentation were deployed for a period of two years beginning in June 1991 as part of an Office of Naval Research (ONR) funded Subduction experiment. Three eight month deployments were planned. The moorings were deployed at 18°N 34°W, 18°N 22°W, 25.5°N 29°W, 33°N 22°W and 33°N 34°W. A Vector Averaging Wind Recorder (VAWR) and an Improved Meteorological Recorder (IMET) collected wind speed and wind direction, sea surface temperature, air temperature, short wave radiation, barometric pressure and relative humidity. The IMET also measured precipitation. The moorings were heavily instrumented below the surface with Vector Measuring Current Meters (VMCM) and single point temperature recorders. Expendable bathythermograph (XBT) data were collected and meteorological observations were made while transmitting between mooring locations. This report describes the work that took place during R/V Knorr cruise number 138 leg XV which was the fourth scheduled Subduction mooring cruise. During this cruise the moorings previously deployed for a third and final eight month period were recovered. This report includes a description of the moorings and instrumentation that were recovered, has information about the underway measurements (XBT and meteorological observations) that were made including plots of the data, and presents a chronology of the cruise events.Funding provided by the Office of Naval Research under Contract No. N00014-90-J-1490
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