476 research outputs found
Measurement-device-independent quantum key distribution with ensemble-based memories
Quantum memories are enabling devices for extending the reach of quantum key distribution (QKD) systems. The required specifications for memories are, however, often considered too demanding for available technologies. One can change this mindset by introducing memory-assisted measurement-device-independent QKD (MDI-QKD), which imposes less stringent conditions on the memory modules. It has been shown that, in the case of fast single-qubit memories, we can reach rates and distances not attainable by single no-memory QKD links. Single-qubit memories, such as single atoms or ions, have, currently, too slow of an access time to offer an advantage in practice. Here, we relax that assumption, and consider ensemble-based memories, which satisfy the main two requirements of having short access times and large storage-bandwidth products. Our results, however, suggest that the multiple-excitation effects in such memories can be so detrimental that they may wash away the scaling improvement offered by memory-equipped systems. We then propose an alternative setup that can in principle remedy the above problem. As a prelude to our main problem, we also obtain secret key generation rates for MDI-QKD systems that rely on imperfect single-photon sources with nonzero probabilities of emitting two photons
A New-Age for Biologic Therapies: Long-Term Drug-Free Therapy with BiP?
Heat shock proteins (HSPs) and other members of the much broader stress protein family have been shown to play important roles in coordinating multiple phases of immunological reactions; from facilitating immunological recognition, to promoting and regulating immunological responses and finally augmenting the resolution of inflammation and return to immunological homeostasis. In this review, we consider the challenges facing the stress protein field as we enter 2012; in particular we consider the role that HSPs and stress proteins may play in the initiation and termination of immunological responses. Special attention is afforded to the resolution-associated molecular pattern, binding immunoglobulin protein (BiP, also known as glucose regulated protein-78). We review the evidence that resolution-promoting proteins such as BiP may herald a new generation of biologics for inflammatory disease and reflect on the challenges of achieving clinical remission in rheumatoid arthritis with novel therapeutics and correlating clinical remission with immunological parameters of resolution of inflammation
The molecular chaperone BiP (GRP 78) inhibits the differentiation of normal human monocytes into immature dendritic cells
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Cognition in action C-i-A: Rethinking gesture in neuro-atypical young people: A conceptual framework for embodied, embedded, extended and enacted intentionality
The three aims of my interdisciplinary thesis are:
-To develop a conceptual framework for re-thinking the gestures of neuro-atypical young people, that is non-traditional and non-representational
-To develop qualitative analytical tools for the annotation and interpretation of gesture that can be applied inclusively to both neuro-atypical and neuro-typical young people
-To consider the conceptual framework in terms of its theoretical implications and practical applications
Learning to communicate and work with neuro-atypical young people provides the rationale and continued impetus for my work. My approach is influenced by the limited social, physical and communicative experiences of young people with severe speech and motor impairment, due to cerebral palsy (SSMI-CP). CP is described as: a range of non-progressive syndromes of posture and motor impairment. The aetiology is thought to result from damage to the developing central nervous system during gestation or in the neonate. Brain lesions involve the basal ganglia and the cerebellum; both these sites are known to support motor control and integration.
However, gaps in theoretical research and empirical data in the study of corporeal expression in young people with SSMI-CP necessitated the development of both an alternative theoretical framework and new tools. Biological Dynamic Systems Theory is proposed as the best candidate structure for the reconsideration of gesture. It encompasses the global, synthetic and embodied nature of gesture. Gesture is redefined and considered part of an emergent dynamic, complex, non-linear and self-organizing system.
My construct of Cognition-in-Action (C-i-A) is derived from the notion of knowing-as-doing influenced by socio-biological paradigms; it places the Action-Ready-Body centre stage. It is informed by a theoretical synthesis of knowledge from the domains of Philosophy, Science and Technology, including practices in the clinical, technology design and performance arts arenas. The C-i-A is a descriptive, non-computational feature-based framework. Its development centred around two key questions that served as operational starting points: What can gestures reveal about children’s cognition-in-action? and Is there the potential to influence gestural capacity in children? These are supported by my research objectives.
Three case studies are presented that focus on the annotation and interpretative analyses of corporeal exemplars from two adolescent males aged 16.9 and 17.9 years, and one female girl aged 10.7 years. These exemplars were contributed to the Child Gesture Corpus by these young people with SSMI-CP. The Gesture-Action-Entity (GAE) is proposed as a unit of interest for the analysis of procedural, semantic and episodic aspects of our corporeal knowledge. A body-based-action-annotation-system (G-ABAS) and Interpretative Phenomenological Analysis methodology is applied for the first time to gesture (G-IPA). These tools facilitate fine-grained corporeal dynamic and narrative gesture feature analyses.
Phenomenal data reveal that these young people have latent resources, capacities and capabilities that they can express corporeally. Iteration of these interpretative findings with the Cognition-in-Action framework allows for the inference of processes that may underlie the strategies they use to achieve such social-motor-cognitive functions. In summary, their Cognition-in-Action is brought-forth, carried forward and has the potential to be culturally embodied.
The utility of C-i-A framework lies in its explanatory power to contribute to a deeper understanding of child gesture. Furthermore, I discuss and illustrate its potential to influence practice in the domains of pedagogy, rehabilitation and the design of future intimate, assistive and perceptually sensitive technologies. Such technologies are increasingly mediating our social interactions. My work offers an ecologically valid alternative to tradition conceptualization of perception, cognition and action. My thesis contributes both new knowledge and carries implications across the domains of movement science, gesture studies and applied participatory performance arts and health practices
Architectural Considerations in Hybrid Quantum-Classical Networks
Three network architectures, compatible with passive optical networks, for future hybrid quantum-classical networks are proposed and compared. These setups rely on three different schemes for quantum key distribution (QKD): BB84, entanglement-based QKD, and measurement-device-independent QKD (MDI-QKD). It turns out that, while for small-to-moderatesize networks BB84 supports the highest secret key generation rate, it may fail to support large numbers of users. Its cost implications are also expected to be higher than other setups. For large networks, MDI-QKD offers the highest key rate if fast single-photon detectors are employed. Entanglement-based networks offer the longest security distance among the three setups. MDI-QKD is, however, the only architecture resilient to detection loopholes and possibly the most favorable with its less demanding end-user technology. Entanglement-based and MDI-QKD setups can both be combined with quantum repeater systems to allow for long-distance QKD with no trust constraints on the service provider
Identification of homing peptides specific for human synovium by in vivo phage display selection
Binding immunoglobulin protein resolves rheumatoid synovitis: a xenogeneic study using rheumatoid arthritis synovial membrane transplants in SCID mice
Perceptions and images of “typical” Australian dishes: An exploratory study
The research investigates the perceived images that ‘typical’ Australian dishes evoke in the minds of consumers, including words they associate to describe typical Australian dishes. A questionnaire designed and distributed among undergraduate students at various universities yielded 561 usable responses. Three predominant responses, grilled/barbequed meats, steaks, and meat pies associated typical Australian dishes with; in addition, Australian dishes evoked four different images among respondents: positive, related to specific images (e.g., barbequed foods), neutral, negative, and food related. Overall, the findings underline limited knowledge. Consumer education could help broaden understanding, with resulting enhanced images of the country’s culinary attributes
Anti-TNF therapies and pregnancy: outcome of 130 pregnancies in the British Society for Rheumatology Biologics Register
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