A Verilog-A Based Fractional Frequency Synthesizer Model for Fast and Accurate Noise Assessment

This paper presents a new strategy to simulate fractional frequency synthesizer behavioral models with better performance and reduced simulation time. The models are described in Verilog-A with accurate phase noise predictions and they are based on a time jitter to power spectral density transformation of the principal noise sources in a synthesizer. The results of a fractional frequency synthesizer simulation is compared with state of the art Verilog-A descriptions showing a reduction of nearly 20 times. In addition, experimental results of a fractional frequency synthesizer are compared to the simulation results to validate the proposed model

Lessons learned from the ATLAS performance studies of the Iberian Cloud for the first LHC running period

In this contribution we describe the performance of the Iberian (Spain and Portugal) ATLAS cloud during the first LHC running period (March 2010-January 2013) in the context of the GRID Computing and Data Distribution Model. The evolution of the resources for CPU, disk and tape in the Iberian Tier-1 and Tier-2s is summarized. The data distribution over all ATLAS destinations is shown, focusing on the number of files transferred and the size of the data. The status and distribution of simulation and analysis jobs within the cloud are discussed. The Distributed Analysis tools used to perform physics analysis are explained as well. Cloud performance in terms of the availability and reliability of its sites is discussed. The effect of the changes in the ATLAS Computing Model on the cloud is analyzed. Finally, the readiness of the Iberian Cloud towards the first Long Shutdown (LS1) is evaluated and an outline of the foreseen actions to take in the coming years is given. The shutdown will be a good opportunity to improve and evolve the ATLAS Distributed Computing system to prepare for the future challenges of the LHC operation.Peer Reviewe

Nucleobindin-1 regulates ECM degradation by promoting intra-Golgi trafficking of MMPs.

Matrix metalloproteinases (MMPs) degrade several ECM components and are crucial modulators of cell invasion and tissue organization. Although much has been reported about their function in remodeling ECM in health and disease, their trafficking across the Golgi apparatus remains poorly understood. Here we report that the cis-Golgi protein nucleobindin-1 (NUCB1) is critical for MMP2 and MT1-MMP trafficking along the Golgi apparatus. This process is Ca2+-dependent and is required for invasive MDA-MB-231 cell migration as well as for gelatin degradation in primary human macrophages. Our findings emphasize the importance of NUCB1 as an essential component of MMP transport and its overall impact on ECM remodeling. © 2020 Pacheco-Fernandez et al

A new method to quantify and compare the multiple components of fitness-A study case with kelp niche partition by divergent microstage adaptations to Temperature

Point 1 Management of crops, commercialized or protected species, plagues or life-cycle evolution are subjects requiring comparisons among different demographic strategies. The simpler methods fail in relating changes in vital rates with changes in population viability whereas more complex methods lack accuracy by neglecting interactions among vital rates. Point 2 The difference between the fitness (evaluated by the population growth rate.) of two alternative demographies is decomposed into the contributions of the differences between the pair-wised vital rates and their interactions. This is achieved through a full Taylor expansion (i.e. remainder = 0) of the demographic model. The significance of each term is determined by permutation tests under the null hypothesis that all demographies come from the same pool. Point 3 An example is given with periodic demographic matrices of the microscopic haploid phase of two kelp cryptic species observed to partition their niche occupation along the Chilean coast. The method provided clear and synthetic results showing conditional differentiation of reproduction is an important driver for their differences in fitness along the latitudinal temperature gradient. But it also demonstrated that interactions among vital rates cannot be neglected as they compose a significant part of the differences between demographies. Point 4 This method allows researchers to access the effects of multiple effective changes in a life-cycle from only two experiments. Evolutionists can determine with confidence the effective causes for changes in fitness whereas population managers can determine best strategies from simpler experimental designs.CONICYT-FRENCH EMBASSADY Ph.D. gran

Orientacions sobre la diversitat cultural i la salut

Diversitat cultural; Atenció sanitària; ImmigracióDiversidad cultural; Atención sanitaria; InmigraciónCultural diversity; Health care; ImmigrationEl respecte a la dignitat, a la llibertat i a la igualtat de les persones pot plantejar dubtes a l’hora de desenvolupar determinades pràctiques socials. L’àmbit sanitari és receptor de moltes peticions i fins i tot d’exigències que els professionals poden arribar a qüestionar dins la seva responsabilitat i el seu compromís social. Cada vegada amb més freqüència, s’adrecen al Comitè Consultiu de Bioètica sol·licituds d’orientació i aclariment respecte de problemes concrets. La via de la casuística circumstancial no sembla la millor manera d’afrontar els problemes actuals. Cal dur a terme una reflexió àmplia, que permeti comprendre la situació i fixar unes línies mestres per abordar els casos concrets. Aquesta és la tasca que s’intenta amb aquest document, és a dir, contribuir a fer el camí vers la comprensió de la diversitat cultural en l’àmbit de la salut, ja iniciat per altres grups institucionals