EVALUATION OF THE CYTOTOXICITY OF PULP FLOOR PERFORATION FILLING MATERIALS BY USING IN PARALLEL 2D AND 3D CULTURE MODELS

Oral Communication presented at the ";Forum des Jeunes Chercheurs";, Brest (France) 2011

Corporate Culture Assessments in Integrative Oncology: A Qualitative Case Study of Two Integrative Oncology Centers

The offer of “integrative oncology” is one option for clinics to provide safe and evidence-based complementary medicine treatments to cancer patients. As known from merger theories, corporate culture and integration models have a strong influence on the success of such integration. To identify relevant corporate culture aspects that might influence the success in two highly visible integrative oncology clinics, we interviewed physicians, nurses, practitioners, and managers. All interviews (11 in a German breast cancer clinic and 9 in an integrative medicine cancer service in the USA) were audio-recorded, transcribed and analyzed with content analysis. According to the theoretical framework of mergers, each clinic selected a different integration type (“best of both worlds” and “linking”). Nonetheless, each developed a similar corporate culture that has a strong focus on research and safe and evidence-based treatments, and fosters a holistic and patient-centered approach. Structured communication within the team and with other departments had high relevance. Research was highlighted as a way to open doors and to facilitate a more general acceptance within the hospital. Conventional physicians felt unburdened by the provision of integrative medicine service but also saw problems in the time required for scheduled treatments, which often resulted in long waiting lists

Merging conventional and complementary medicine in a clinic department – a theoretical model and practical recommendations

BACKGROUND: Today, the increasing demand for complementary medicine encourages health care providers to adapt and create integrative medicine departments or services within clinics. However, because of their differing philosophies, historical development, and settings, merging the partners (conventional and complementary medicine) is often difficult. It is necessary to understand the similarities and differences in both cultures to support a successful and sustainable integration. The aim of this project was to develop a theoretical model and practical steps that are based on theories from mergers in business to facilitate the implementation of an integrative medicine department. METHODS: Based on a literature search and expert discussions, the cultures were described and model domains were developed. These were applied to two case studies to develop the final model. Furthermore, a checklist with practical steps was devised. RESULTS: Conventional medicine and complementary medicine have developed different corporate cultures. The final model, which should help to foster integration by bridging between these cultures, is based on four overall aspects: culture, strategy, organizational tools and outcomes. Each culture is represented by three dimensions in the model: corporate philosophy (core and identity of the medicine and the clinic), patient (all characteristics of the professional team's contact with the patient), and professional team (the characteristics of the interactions within the professional team). CONCLUSION: Overall, corporate culture differs between conventional and complementary medicine; when planning the implementation of an integrative medicine department, the developed model and the checklist can support better integration

M-ficolin interacts with the long pentraxin PTX3: a novel case of cross-talk between soluble pattern-recognition molecules.

International audienceFicolins and pentraxins are soluble oligomeric pattern-recognition molecules that sense danger signals from pathogens and altered self-cells and might act synergistically in innate immune defense and maintenance of immune tolerance. The interaction of M-ficolin with the long pentraxin pentraxin 3 (PTX3) has been characterized using surface plasmon resonance spectroscopy and electron microscopy. M-ficolin was shown to bind PTX3 with high affinity in the presence of calcium ions. The interaction was abolished in the presence of EDTA and inhibited by N-acetyl-D-glucosamine, indicating involvement of the fibrinogen-like domain of M-ficolin. Removal of sialic acid from the single N-linked carbohydrate of the C-terminal domain of PTX3 abolished the interaction. Likewise, an M-ficolin mutant with impaired sialic acid-binding ability did not interact with PTX3. Interaction was also impaired when using the isolated recognition domain of M-ficolin or the monomeric C-terminal domain of PTX3, indicating requirement for oligomerization of both proteins. Electron microscopy analysis of the M-ficolin-PTX3 complexes revealed that the M-ficolin tetramer bound up to four PTX3 molecules. From a functional point of view, immobilized PTX3 was able to trigger M-ficolin-dependent activation of the lectin complement pathway. These data indicate that interaction of M-ficolin with PTX3 arises from its ability to bind sialylated ligands and thus differs from the binding to the short pentraxin C-reactive protein and from the binding of L-ficolin to PTX3. The M-ficolin-PTX3 interaction described in this study represents a novel case of cross-talk between soluble pattern-recognition molecules, lending further credit to the integrated view of humoral innate immunity that emerged recently

Viticulture tropicale dans le monde : caractéristiques et limites climatiques.

La vitiviniculture tropicale affiche une expansion très rapide pour de multiples raisons (économiques, politiques, sanitaires, etc.). Dans l?espace intertropical, l?absence de saison froide permet une croissance continue de la vigne, offrant la possibilité de réaliser plusieurs récoltes par an. Tropical viticulture in the world: climatic characteristics and limits Tropical vitiviniculture is expanding rapidly for a variety of reasons (economic, political, health, etc.). Between the tropics, the absence of a cold season allows a continuous growth of the vine, offering the possibility of making several harvests a year. The beginning of each "vegetative cycle" of the vine is controlled by human intervention, which makes it possible to choose the time of year when the climatic conditions are most favorable to the oenological potential of the grape. But this "flexibility" is not systematic. Viticultura tropicale nel mondo : caratteristiche e limiti climatici La vitivinicultura tropicale mostra una espansione molto rapida a causa di molti fattori (economici, politici, sanitari, etc.). Nello spazio intertropicale , l?assenza della stagione fredda permette una crescita continua della vite, permettendo la realizzazione di piu? raccolti per anno.L?inizio di ogni «ciclo vegetativo» della vite é controllato a traverso l?intervento umano, permettendo quindi di ottimizzare la scelta del periodo,o deiperiodi,dell?anno con le condizioni climatiche il piu favorevole possibile per il potenziale enologico dell?uva.CONGRESO MUNDIAL DE LA VIÑA Y EL VINO, 41., ASEMBLE GENERAL DE LA ORGANIZACIÓN INTERNACIONAL DE LA VIÑA Y EL VINO, 16.,2018, Punta del Este, UR. Anais...Punta Del Este: OIV, 19 al 23 de noviembre 2018. http://www.oiv.int/es/la-organizacion-intenacional-de-la-vina-y-el-vino/congreso-oi