Biosynthesis of the protoberberine alkaloid jatrorrhizine

Feeding experiments with distant single or doubly labelled precursors show that the methylene dioxy group of berberine is opened in the formation of jatrorrhizine

From non-symmetric particle systems to non-linear PDEs on fractals

We present new results and challenges in obtaining hydrodynamic limits for non-symmetric (weakly asymmetric) particle systems (exclusion processes on pre-fractal graphs) converging to a non-linear heat equation. We discuss a joint density-current law of large numbers and a corresponding large deviations principle.Comment: v2: 10 pages, 1 figure. To appear in the proceedings for the 2016 conference "Stochastic Partial Differential Equations & Related Fields" in honor of Michael R\"ockner's 60th birthday, Bielefel

Student-Athletes in my Classroom: Australian Teachers’ Perspectives of the Problems Faced by Student-Athletes Balancing School and Sport

This paper emerged from a larger project about Australian high performance school age athletes self-identified problems in balancing their academic and sporting lives. Teachers of student-athletes are ideally placed to observe stresses faced by these students, but little is published about teacher perspectives on this topic. A qualitative analysis of interview data from 10 teachers, across 10 Australian secondary schools, revealed critical information about the similarities and differences in their perspectives compared to those of student-athletes and parents. Teachers identified five main areas where student-athletes required dedicated support, and provided examples of solutions to address these. Their practical strategies complement the characteristics of the ‘athlete-friendly’ school and serve as examples of best practice support that other schools could adopt. On analysis, these strategies align with the Australian Professional Standards for Teachers. Consequently, the focus of this paper relates to the teacher perspectives and how this impacts teacher practice

Absolute physical calibration in the infrared

We determine an absolute calibration for the Multiband Imaging Photometer for Spitzer 24 μm band and recommend adjustments to the published calibrations for Two Micron All Sky Survey (2MASS), Infrared Array Camera (IRAC), and IRAS photometry to put them on the same scale. We show that consistent results are obtained by basing the calibration on either an average A0V star spectral energy distribution (SED), or by using the absolutely calibrated SED of the Sun in comparison with solar-type stellar photometry (the solar analog method). After the rejection of a small number of stars with anomalous SEDs (or bad measurements), upper limits of ~1.5% root mean square (rms) are placed on the intrinsic infrared (IR) SED variations in both A-dwarf and solar-type stars. These types of stars are therefore suitable as general-purpose standard stars in the IR. We provide absolutely calibrated SEDs for a standard zero magnitude A star and for the Sun to allow extending this work to any other IR photometric system. They allow the recommended calibration to be applied from 1 to 25 μm with an accuracy of ~2%, and with even higher accuracy at specific wavelengths such as 2.2, 10.6, and 24 μm, near which there are direct measurements. However, we confirm earlier indications that Vega does not behave as a typical A0V star between the visible and the IR, making it problematic as the defining star for photometric systems. The integration of measurements of the Sun with those of solar-type stars also provides an accurate estimate of the solar SED from 1 through 30 μm, which we show agrees with theoretical models

Exoplanet science with the LBTI: instrument status and plans

The Large Binocular Telescope Interferometer (LBTI) is a strategic instrument of the LBT designed for high-sensitivity, high-contrast, and high-resolution infrared (1.5-13 $\mu$m) imaging of nearby planetary systems. To carry out a wide range of high-spatial resolution observations, it can combine the two AO-corrected 8.4-m apertures of the LBT in various ways including direct (non-interferometric) imaging, coronagraphy (APP and AGPM), Fizeau imaging, non-redundant aperture masking, and nulling interferometry. It also has broadband, narrowband, and spectrally dispersed capabilities. In this paper, we review the performance of these modes in terms of exoplanet science capabilities and describe recent instrumental milestones such as first-light Fizeau images (with the angular resolution of an equivalent 22.8-m telescope) and deep interferometric nulling observations.Comment: 12 pages, 6 figures, Proc. SPI

Simultaneous Water Vapor and Dry Air Optical Path Length Measurements and Compensation with the Large Binocular Telescope Interferometer

The Large Binocular Telescope Interferometer uses a near-infrared camera to measure the optical path length variations between the two AO-corrected apertures and provide high-angular resolution observations for all its science channels (1.5-13 $\mu$m). There is however a wavelength dependent component to the atmospheric turbulence, which can introduce optical path length errors when observing at a wavelength different from that of the fringe sensing camera. Water vapor in particular is highly dispersive and its effect must be taken into account for high-precision infrared interferometric observations as described previously for VLTI/MIDI or the Keck Interferometer Nuller. In this paper, we describe the new sensing approach that has been developed at the LBT to measure and monitor the optical path length fluctuations due to dry air and water vapor separately. After reviewing the current performance of the system for dry air seeing compensation, we present simultaneous H-, K-, and N-band observations that illustrate the feasibility of our feedforward approach to stabilize the path length fluctuations seen by the LBTI nuller.Comment: SPIE conference proceeding

L'-band AGPM vector vortex coronagraph's first light on LBTI/LMIRCam

We present the first observations obtained with the L'-band AGPM vortex coronagraph recently installed on LBTI/LMIRCam. The AGPM (Annular Groove Phase Mask) is a vector vortex coronagraph made from diamond subwavelength gratings. It is designed to improve the sensitivity and dynamic range of high-resolution imaging at very small inner working angles, down to 0.09 arcseconds in the case of LBTI/LMIRCam in the L' band. During the first hours on sky, we observed the young A5V star HR\,8799 with the goal to demonstrate the AGPM performance and assess its relevance for the ongoing LBTI planet survey (LEECH). Preliminary analyses of the data reveal the four known planets clearly at high SNR and provide unprecedented sensitivity limits in the inner planetary system (down to the diffraction limit of 0.09 arcseconds).Comment: 9 pages, 4 figures, SPIE proceeding

Constraining the Exozodiacal Luminosity Function of Main-sequence Stars: Complete Results from the Keck Nuller Mid-infrared Surveys

Forty-seven nearby main-sequence stars were surveyed with the Keck Interferometer mid-infrared Nulling instrument (KIN) between 2008 and 2011, searching for faint resolved emission from exozodiacal dust. Observations of a subset of the sample have already been reported, focusing essentially on stars with no previously known dust. Here we extend this previous analysis to the whole KIN sample, including 22 more stars with known near-and/or far-infrared excesses. In addition to an analysis similar to that of the first paper of this series, which was restricted to the 8-9 µm spectral region, we present measurements obtained in all 10 spectral channels covering the 8-13 µm instrumental bandwidth. Based on the 8-9 µm data alone, which provide the highest signal-to-noise measurements, only one star shows a large excess imputable to dust emission (η Crv), while four more show a significant (> 3σ) excess: β Leo, β UMa, ζ Lep, and y Oph. Overall, excesses detected by KIN are more frequent around A-type stars than later spectral types. Astatistical analysis of the measurements further indicates that stars with known far-infrared (y ≥ 70 µm) excesses have higher exozodiacal emission levels than stars with no previous indication of a cold outer disk. This statistical trend is observed regardless of spectral type and points to a dynamical connection between the inner (zodi-like) and outer (Kuiper-Belt-like) dust populations. The measured levels for such stars are clustering close to the KIN detection limit of a few hundred zodis and are indeed consistent with those expected from a population of dust that migrated in from the outer belt by Poynting-Robertson drag. Conversely, no significant mid-ilinfrared excess is found around sources with previously reported near-infrared resolved excesses, which typically have levels of the order of 1% over the photospheric flux. If dust emission is really at play in these near-infrared detections, the absence of a strong mid-infrared counterpart points to populations of very hot and small (submicron) grains piling up very close to the sublimation radius. For solar-type stars with no known infrared excess, likely to be the most relevant targets for a future exo-Earth direct imaging mission, we find that their median zodi level is 12±24 zodis and lower than 60 (90) zodis with 95% (99%) confidence, if a lognormal zodi luminosity distribution is assumed

Interaction of pregnancy-specific glycoprotein 1 with integrin Α5β1 is a modulator of extravillous trophoblast functions

Human pregnancy-specific glycoproteins (PSGs) serve immunomodulatory and pro-angiogenic functions during pregnancy and are mainly expressed by syncytiotrophoblast cells. While PSG mRNA expression in extravillous trophoblasts (EVTs) was reported, the proteins were not previously detected. By immunohistochemistry and immunoblotting, we show that PSGs are expressed by invasive EVTs and co-localize with integrin α5. In addition, we determined that native and recombinant PSG1, the most highly expressed member of the family, binds to α5β1 and induces the formation of focal adhesion structures resulting in adhesion of primary EVTs and EVT-like cell lines under 21% oxygen and 1% oxygen conditions. Furthermore, we found that PSG1 can simultaneously bind to heparan sulfate in the extracellular matrix and to α5β1 on the cell membrane. Wound healing assays and single-cell movement tracking showed that immobilized PSG1 enhances EVT migration. Although PSG1 did not affect EVT invasion in the in vitro assays employed, we found that the serum PSG1 concentration is lower in African-American women diagnosed with early-onset and late-onset preeclampsia, a pregnancy pathology characterized by shallow trophoblast invasion, than in their respective healthy controls only when the fetus was a male; therefore, the reduced expression of this molecule should be considered in the context of preeclampsia as a potential therapy

First-light LBT nulling interferometric observations: warm exozodiacal dust resolved within a few AU of eta Corvi

We report on the first nulling interferometric observations with the Large Binocular Telescope Interferometer (LBTI), resolving the N' band (9.81 - 12.41 um) emission around the nearby main-sequence star eta Crv (F2V, 1-2 Gyr). The measured source null depth amounts to 4.40% +/- 0.35% over a field-of-view of 140 mas in radius (~2.6\,AU at the distance of eta Corvi) and shows no significant variation over 35{\deg} of sky rotation. This relatively low null is unexpected given the total disk to star flux ratio measured by Spitzer/IRS (~23% across the N' band), suggesting that a significant fraction of the dust lies within the central nulled response of the LBTI (79 mas or 1.4 AU). Modeling of the warm disk shows that it cannot resemble a scaled version of the Solar zodiacal cloud, unless it is almost perpendicular to the outer disk imaged by Herschel. It is more likely that the inner and outer disks are coplanar and the warm dust is located at a distance of 0.5-1.0 AU, significantly closer than previously predicted by models of the IRS spectrum (~3 AU). The predicted disk sizes can be reconciled if the warm disk is not centrosymmetric, or if the dust particles are dominated by very small grains. Both possibilities hint that a recent collision has produced much of the dust. Finally, we discuss the implications for the presence of dust at the distance where the insolation is the same as Earth's (2.3 AU).Comment: 9 pages, 6 figures, accepted for publication in Ap