Structure of ethyl 1-cyanomethyl-5-methoxy-3-phenylindole-2-carboxylate

C20HI8N203, M r = 334.38, orthorhombic, Pbca, a = 7.179 (3), b = 33.014 (3), c = 14.847 (1) A, V = 3518.85/~3, Z = 8, Dx = 1.262, D m = by 53.1 (3) °. The C--C~N chain is linear and makes a dihedral angle of 77.9 (3) ° with the mean plane of the indole ring. The mean plane of the carboxyl group makes a dihedral angle of 25.4 (3) ° with the indole moiety

Maternal and perinatal outcome in abruption placenta in tertiary care center: a record based case series study

Background: Abruptio placenta is premature separation of the normally implanted placenta before delivery. It is one of the leading causes of maternal morbidity and neonatal morbidity and mortality, more so because of the difficulty to predict the acute event. It occurs in approximately one in 80 deliveries and remains a significant cause of perinatal mortality and morbidity. Objective of the study was to study maternal and perinatal outcome in cases of abruption. Methods: 42 cases of pregnant women who presented with abruption placenta to HSK hospital and Research Centre, S. Nijalingappa Medical College, a tertiary care centre at Bagalkot, from January 2022 to December 2022. Maternal and perinatal characteristics were retrieved from the case papers. Results: Among 42 cases of abruption 70% delivered vaginally and 30% underwent caesarean section. 84% had preterm delivery. 66% were still born. 21% were case of severe anaemia and required blood transfusion. 1 had maternal mortality. Conclusions: The availability of advanced emergency obstetric care across greater number of referral hospitals has been responsible for decreasing the morbidity and mortality associated with many obstetric conditions. However, the challenge with abruptio placenta is the difficulty of predicting this condition, and hence appropriate management. As of now, early referral to tertiary care centres, better availability of blood and blood products and early interventions have the potential to limit adverse maternal and perinatal outcomes. Research regarding predictors of placental abruption can help in improving maternal and perinatal outcome.

Sequence and phylogenetic analysis of viper venom serine proteases

Snakebites are a major neglected tropical disease responsible for as many as 95000 deaths every year worldwide. Viper venom serine proteases disrupt haemostasis of prey and victims by affecting various stages of the blood coagulation system. A better understanding of their sequence, structure, function and phylogenetic relationships will improve the knowledge on the pathological conditions and aid in the development of novel therapeutics for treating snakebites. A large dataset for all available viper venom serine proteases was developed and analysed to study various features of these enzymes. Despite the large number of venom serine protease sequences available, only a small proportion of these have been functionally characterised. Although, they share some of the common features such as a C-terminal extension, GWG motif and disulphide linkages, they vary widely between each other in features such as isoelectric points, potential N-glycosylation sites and functional characteristics. Some of the serine proteases contain substitutions for one or more of the critical residues in catalytic triad or primary specificity pockets. Phylogenetic analysis clustered all the sequences in three major groups. The sequences with substitutions in catalytic triad or specificity pocket clustered together in separate groups. Our study provides the most complete information on viper venom serine proteases to date and improves the current knowledge on the sequence, structure, function and phylogenetic relationships of these enzymes. This collective analysis of venom serine proteases will help in understanding the complexity of envenomation and potential therapeutic avenues

Ethyl 3-oxo-2-[(4-sulfamoylphen­yl)hydra­zono]butyrate

In the title compound, C12H15N3O5S, an intra­molecular N—H⋯O hydrogen bond between the hydrazine unit and one of the carbonyl groups may influence the mol­ecular conformation. In the crystal structure, inter­molecular N—H⋯O hydrogen bonds, including one which is bifurcated, link the mol­ecules into a two-dimensional network

Rhodium(I) complexes of α-keto-stabilised 1,2-bis(diphenylphosphino)alkane mono ylides

Rhodium(I) complexes of the hybrid ylide-phosphine ligands, Ph2P(CH2) n PPh2(CHC(O)C6H5) (n = 1: dppm-yl, or 2: dppe-yl) have been synthesised from [Rh(μ-C1)(COD)]2 (COD = 1,5-cyclooctadiene) and characterized by NMR spectroscopic and X-ray structural methods. The dppe-yl behaves as an ambidentate ligand; it functions as a monodentate P-donor ligand with a dangling ylidic carbon in the neutral chloro complex, [(COD)Rh(Cl)(dppe-yl)] (1), whereas replacement of the chloride by a non-coordinating counter anion results in the formation of the complexes, [(COD)Rh(L-L')]+ (L-L' = dppe-yl (2) or dppm-yl (3)) respectively in which the ligands are bonded to the metal via the phosphorus and the ylidic carbon atoms. The 1,5-cyclooctadiene (COD), present in the Rh(I) precursor, remains intact in the products. The structures of 1,2 and3 have been confirmed by X-ray crystallography

Methyl 2,2-bis­(2,4-dinitro­phen­yl)ethano­ate

In the title compound, C15H10N4O10, the dihedral angle between the aromatic rings is 89.05 (16)°. One O atom of one of the nitro groups is disordered over two sites in a 0.70:0.30 ratio. In the crystal, the mol­ecules are linked by weak C—H⋯O inter­actions

Crystal structure of nonadentate tricompartmental ligand derived from pyridine-2,6-dicarboxylic acid: Spectroscopic, electrochemical and thermal investigations of its transition metal(II) complexes

The coordinating behavior of a new dihydrazone ligand, 2,6-bis(3- methoxysalicylidene)hydrazinocarbonylpyridine towards manganese(II), cobalt(II), nickel(II), copper(II), zinc(II) and cadmium(II) has been described. The metal complexes were characterized by magnetic moments, conductivity measurements, spectral (IR, NMR, UV-Vis, FAB-Mass and EPR) and thermal studies. The ligand crystallizes in triclinic system, space group P-1, with α = 98.491(10)°, β = 110.820(10)° and γ = 92.228(10)°. The cell dimensions are a = 10.196(7) , b = 10.814(7) , c = 10.017(7) , Z = 2 and V = 1117.4(12). IR spectral studies reveal the nonadentate behavior of the ligand. All the complexes are neutral in nature and possess six-coordinate geometry around each metal center. The X-band EPR spectra of copper(II) complex at both room temperature and liquid nitrogen temperature showed unresolved broad signals with giso = 2.106. Cyclic voltametric studies of copper(II) complex at different scan rates reveal that all the reaction occurring are irreversible. © 2011 Elsevier B.V

4-[2-(1-Acetyl-2-oxopropyl­idene)­hydrazino]-N-(pyrimidin-2-yl)benzene­sulfonamide

In the title compound, C15H15N5O4S, the dihedral angle between the pyrimidine and benzene rings is 84.56 (2)°. Intra­molecular hydrazine–carbonyl N—H⋯O and inter­molecular sulfonamide–pyridimine N—H⋯N hydrogen bonds stabilize the mol­ecular and crystal structures, respectively

On the Practical Limitations for the Generation of Gunn Oscillations in Highly Doped GaN Diodes

Planar Gunn diodes based on doped GaN active layers with different geometries have been fabricated and characterized. Gunn oscillations have not been observed due to the catastrophic breakdown of the diodes for applied voltages around 20-25 V, much below the bias theoretically needed for the onset of Gunn oscillations. The breakdown of the diodes has been analyzed by pulsed I-V measurements at low temperature, and it has been observed to be almost independent of the geometry of the channels, thus allowing to discard self-heating effects as the origin of the device burning. The other possible mechanism for the device failure is impact-ionization avalanche due to the high electric fields present at the anode corner of the isolating trenches. However, Monte Carlo simulations using the typical value of the intervalley energy separation of GaN, ε_(1-2)=2.2 eV, show that impact ionization mechanisms are not significant for the voltages for which the experimental failure is observed. But recent experiments showed that ε_(1-2) is lower, around 0.9 eV. This lower intervalley separation leads to a much lower threshold voltage for the Gunn oscillations, not far from the experimental breakdown. Therefore, we attribute the devices failure to an avalanche process just when Gunn domains start to form, since they increase the population of electrons at the high electric field region, thus strongly enhancing impact ionization mechanisms which lead to the diode failure

Expression, purification, crystallization and preliminary crystallographic analysis of a putative Clostridium difficile surface protein Cwp19

Cwp19 is a putatively surface-located protein from Clostridium difficile. A recombinant N-terminal protein (residues 27–401) lacking the signal peptide and the C-terminal cell-wall-binding repeats (PFam04122) was crystallized using the sitting-drop vapour-diffusion method and diffracted to 2 Å resolution