54 research outputs found
Academic Success and Christian Affiliation in College
The goal of our study was to provide a more thorough understanding of the relationship between religious attitudes and academic success, and will provide direction for future research in this domain. Our research examined the relationship between Christianity, academic achievement, and mediating variables in college-aged students. Past studies regarding religion and academic success have found that in some communities, academic success is positively correlated with religious involvement. However, these studies primarily looked at academic success in relation to involvement in a religious community, and not to personal attitudes regarding religion. To gain a better understanding of the role of personal religious attitudes in academic success, this study specifically examined academic success in relation to Christian affiliation and spirituality, as well as intrinsic dispositions of positivity and mastery. These mediating variables were included to control for factors that may relate to both academic success and religiosity, providing a more complete view of the relationship between religious attitudes and academic success. Study participants included college students currently attending a small, public, liberal-arts university. The study utilized a descriptive research design in which participants self-reported details about their demographics, academic performance (i.e. GPA and participation in honors programming), religious beliefs, and personality characteristics associated with outlook and hopefulness. Our presentation will examine the results of our study in relation to questions regarding the role of personal beliefs and dispositions in academic success.https://digitalcommons.morris.umn.edu/urs_2015/1002/thumbnail.jp
Understanding and Contextualizing Precedents in e-Discovery: The Illusion of Stare Decisis and Best Practices to Avoid Reliance on Outdated Guidance
But as precedents survive like the clavicle in the cat, long after the use they once served is at an end, and the reason for them has been forgotten, the result of following them must often be failure and confusion from the merely logical point of view
Mechanism of human PINK1 activation at the TOM complex by reconstitution
Loss of function mutations in PTEN-induced kinase 1 (PINK1) are a frequent cause of earlyonset Parkinson’s disease (PD). Stabilisation of PINK1 at the Translocase of Outer Membrane (TOM) complex of damaged mitochondria is a critical step for its activation. To date the mechanism of how PINK1 is activated in the TOM complex is unclear. Herein we report coexpression of human PINK1 and all seven TOM subunits in Saccharomyces cerevisiae is sufficient for PINK1 activation. We use this reconstitution system to systematically assess the role of each TOM subunit towards PINK1 activation. We unambiguously demonstrate that the TOM20 and TOM70 receptor subunits are required for optimal PINK1 activation and map their sites of interaction with PINK1 using AlphaFold structural modelling and mutagenesis. We also demonstrate an essential role of the pore-containing subunit TOM40 and its structurally associated subunits TOM7 and TOM22 for PINK1 activation. These molecular findings will aid in the development of small molecule activators of PINK1 as a therapeutic strategy for PD
Mechanism of human PINK1 activation at the TOM complex by reconstitution
Loss of function mutations in PTEN-induced kinase 1 (PINK1) are a frequent cause of earlyonset Parkinson’s disease (PD). Stabilisation of PINK1 at the Translocase of Outer Membrane (TOM) complex of damaged mitochondria is a critical step for its activation. To date the mechanism of how PINK1 is activated in the TOM complex is unclear. Herein we report coexpression of human PINK1 and all seven TOM subunits in Saccharomyces cerevisiae is sufficient for PINK1 activation. We use this reconstitution system to systematically assess the role of each TOM subunit towards PINK1 activation. We unambiguously demonstrate that the TOM20 and TOM70 receptor subunits are required for optimal PINK1 activation and map their sites of interaction with PINK1 using AlphaFold structural modelling and mutagenesis. We also demonstrate an essential role of the pore-containing subunit TOM40 and its structurally associated subunits TOM7 and TOM22 for PINK1 activation. These molecular findings will aid in the development of small molecule activators of PINK1 as a therapeutic strategy for PD
Mechanism of human PINK1 activation at the TOM complex in a reconstituted system
Loss-of-function mutations in PTEN-induced kinase 1 (PINK1) are a frequent cause of early-onset Parkinson's disease (PD). Stabilization of PINK1 at the translocase of outer membrane (TOM) complex of damaged mitochondria is critical for its activation. The mechanism of how PINK1 is activated in the TOM complex is unclear. Here, we report that co-expression of human PINK1 and all seven TOM subunits in Saccharomyces cerevisiae is sufficient for PINK1 activation. We use this reconstitution system to systematically assess the role of each TOM subunit toward PINK1 activation. We unambiguously demonstrate that the TOM20 and TOM70 receptor subunits are required for optimal PINK1 activation and map their sites of interaction with PINK1 using AlphaFold structural modeling and mutagenesis. We also demonstrate an essential role of the pore-containing subunit TOM40 and its structurally associated subunits TOM7 and TOM22 for PINK1 activation. These findings will aid in the development of small-molecule activators of PINK1 as a therapeutic strategy for PD.</p
Mechanism of human PINK1 activation at the TOM complex in a reconstituted system
Loss-of-function mutations in PTEN-induced kinase 1 (PINK1) are a frequent cause of early-onset Parkinson's disease (PD). Stabilization of PINK1 at the translocase of outer membrane (TOM) complex of damaged mitochondria is critical for its activation. The mechanism of how PINK1 is activated in the TOM complex is unclear. Here, we report that co-expression of human PINK1 and all seven TOM subunits in Saccharomyces cerevisiae is sufficient for PINK1 activation. We use this reconstitution system to systematically assess the role of each TOM subunit toward PINK1 activation. We unambiguously demonstrate that the TOM20 and TOM70 receptor subunits are required for optimal PINK1 activation and map their sites of interaction with PINK1 using AlphaFold structural modeling and mutagenesis. We also demonstrate an essential role of the pore-containing subunit TOM40 and its structurally associated subunits TOM7 and TOM22 for PINK1 activation. These findings will aid in the development of small-molecule activators of PINK1 as a therapeutic strategy for PD.</p
Comprehensive landscape of active deubiquitinating enzymes profiled by advanced chemoproteomics
Implementering av nasjonal retningslinje for tromboseprofylakse. Medisinske høyrisikopasienter, Sykehuset i Vestfold, Tønsberg
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