Shell-like structures in our cosmic neighbourhood

Signatures of the processes in the early Universe are imprinted in the cosmic web. Some of them may define shell-like structures characterised by typical scales. We search for shell-like structures in the distribution of nearby rich clusters of galaxies drawn from the SDSS DR8. We calculate the distance distributions between rich clusters of galaxies, and groups and clusters of various richness, look for the maxima in the distance distributions, and select candidates of shell-like structures. We analyse the space distribution of groups and clusters forming shell walls. We find six possible candidates of shell-like structures, in which galaxy clusters have maxima in the distance distribution to other galaxy groups and clusters at the distance of about 120 Mpc/h. The rich galaxy cluster A1795, the central cluster of the Bootes supercluster, has the highest maximum in the distance distribution of other groups and clusters around them at the distance of about 120 Mpc/h among our rich cluster sample, and another maximum at the distance of about 240 Mpc/h. The structures of galaxy systems causing the maxima at 120 Mpc/h form an almost complete shell of galaxy groups, clusters and superclusters. The richest systems in the nearby universe, the Sloan Great Wall, the Corona Borealis supercluster and the Ursa Major supercluster are among them. The probability that we obtain maxima like this from random distributions is lower than 0.001. Our results confirm that shell-like structures can be found in the distribution of nearby galaxies and their systems. The radii of the possible shells are larger than expected for a BAO shell (approximately 109 Mpc/h versus approximately 120 Mpc/h), and they are determined by very rich galaxy clusters and superclusters with high density contrast while BAO shells are barely seen in the galaxy distribution. We discuss possible consequences of these differences.Comment: Comments: 9 pages, 10 figures, Astronomy and Astrophysics, in pres

RIP2 plays a role in cardiac Ca2+ mishandling prompted by chronic kidney disease

post-print81,7 K

The alhambra survey: evolution of galaxy spectral segregation

We study the clustering of galaxies as a function of spectral type and redshift in the range 0.35 <z <1.1 using data from the Advanced Large Homogeneous Area Medium Band Redshift Astronomical (ALHAMBRA) survey. The data cover 2.381 deg2 in 7 fields, after applying a detailed angular selection mask, with accurate photometric redshifts down to IAB <24. From this catalog we draw five fixed number density redshift-limited bins. We estimate the clustering evolution for two different spectral populations selected using the ALHAMBRA-based photometric templates: quiescent and star-forming galaxies. For each sample we measure the real-space clustering using the projected correlation function. Our calculations are performed over the range [0.03, 10.0] h-1 Mpc, allowing us to find a steeper trend for Mpc, which is especially clear for star-forming galaxies. Our analysis also shows a clear early differentiation in the clustering properties of both populations: star-forming galaxies show weaker clustering with evolution in the correlation length over the analyzed redshift range, while quiescent galaxies show stronger clustering already at high redshifts and no appreciable evolution. We also perform the bias calculation where similar segregation is found, but now it is among the quiescent galaxies where a growing evolution with redshift is clearer (abrigatted). These findings clearly corroborate the well-known color-density relation, confirming that quiescent galaxies are mainly located in dark matter halos that are more massive than those typically populated by star-forming galaxies.Ministerio de Economía y Competitividad y FEDER AYA2010-22111-C03-02 AYA2013-48623-C2-2 AYA2012-39620 AYA2013-40611-P AYA2013-42227-P AYA2013-43188-P AYA2013-48623-C2-1 ESP2013-48274 AYA2014-58861-C3-1Junta de Andalucía TIC114 JA2828 P10-FQM-644

Genetic Deletion of NOD1 Prevents Cardiac Ca2+ Mishandling Induced by Experimental Chronic Kidney Disease

© 2020 by the authors.Risk of cardiovascular disease (CVD) increases considerably as renal function declines in chronic kidney disease (CKD). Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) has emerged as a novel innate immune receptor involved in both CVD and CKD. Following activation, NOD1 undergoes a conformational change that allows the activation of the receptor-interacting serine/threonine protein kinase 2 (RIP2), promoting an inflammatory response. We evaluated whether the genetic deficiency of Nod1 or Rip2 in mice could prevent cardiac Ca2+ mishandling induced by sixth nephrectomy (Nx), a model of CKD. We examined intracellular Ca2+ dynamics in cardiomyocytes from Wild-type (Wt), Nod1−/− and Rip2−/− sham-operated or nephrectomized mice. Compared with Wt cardiomyocytes, Wt-Nx cells showed an impairment in the properties and kinetics of the intracellular Ca2+ transients, a reduction in both cell shortening and sarcoplasmic reticulum Ca2+ load, together with an increase in diastolic Ca2+ leak. Cardiomyocytes from Nod1−/−-Nx and Rip2−/−-Nx mice showed a significant amelioration in Ca2+ mishandling without modifying the kidney impairment induced by Nx. In conclusion, Nod1 and Rip2 deficiency prevents the intracellular Ca2+ mishandling induced by experimental CKD, unveiling new innate immune targets for the development of innovative therapeutic strategies to reduce cardiac complications in patients with CKD.This work was supported by Spanish Ministry of Economy and Competitiveness and European Regional Development Fund (SAF-2017-84777R), Institute of Health Carlos III (PI17/01093 and PI17/01344), Sociedad Española de Cardiología, Proyecto Traslacional 2019, Fundación Renal Íñigo Álvarez de Toledo (FRIAT), Fondo Europeo de Desarrollo Regional (FEDER), FSE, and CIBER-CV, a network funded by ISCIII. M.F.-V. is Miguel Servet II researcher of ISCIII (MSII16/00047 Carlos III Health Institute). G.R.-H. is Miguel Servet I researcher of ISCIII (CP15/00129 Carlos III Health Institute). M.T. is a PhD student funded by the FPU program of the Spanish Ministry of Science, Innovation and Universities (FPU17/06135). A.R. was supported by Fondo SEP-Cinvestav project #601410 FIDSC 2018/2; and Fondo SEP-Conacyt Ciencia Básica A1-S-9082

First evidence of coherent K+K^{+} meson production in neutrino-nucleus scattering

Neutrino-induced charged-current coherent kaon production, $\nu_{\mu}A\rightarrow\mu^{-}K^{+}A$, is a rare, inelastic electroweak process that brings a $K^+$ on shell and leaves the target nucleus intact in its ground state. This process is significantly lower in rate than neutrino-induced charged-current coherent pion production, because of Cabibbo suppression and a kinematic suppression due to the larger kaon mass. We search for such events in the scintillator tracker of MINERvA by observing the final state $K^+$, $\mu^-$ and no other detector activity, and by using the kinematics of the final state particles to reconstruct the small momentum transfer to the nucleus, which is a model-independent characteristic of coherent scattering. We find the first experimental evidence for the process at $3\sigma$ significance.Comment: added ancillary file with information about the six kaon candidate

Shell-like structures in our cosmic neighbourhood

Context. Signatures of the processes in the early Universe are imprinted in the cosmic web. Some of them may define shell-like structures characterised by typical scales. Examples of such structures are shell-like systems of galaxies, which are interpreted as a signatures of the baryon acoustic oscillations.Aims. We search for shell-like structures in the distribution of nearby rich clusters of galaxies drawn from the SDSS DR8.Methods. We calculated the distance distributions between rich clusters of galaxies and groups and clusters of various richness, searched for the maxima in the distance distributions and selected candidates of shell-like structures. We analysed the space distribution of groups and clusters that form shell walls.Results. We find six possible candidates of shell-like structures, in which galaxy clusters have the maximum in their distance distribution to other galaxy groups and clusters at a distance of about 120-130 h(-1) Mpc. Another, less probable maximum is found at a distance of about 240 h(-1) Mpc. The rich galaxy cluster A1795, which is the central cluster of the Bootes supercluster, has the highest maximum in the distance distribution of all other surrounding groups and clusters in our rich cluster sample. It lies at a distance of about 120 h(-1) Mpc. The structures of galaxy systems that cause this maximum form an almost complete shell of galaxy groups, clusters, and superclusters. The richest systems in the nearby universe, the Sloan Great Wall, the Corona Borealis supercluster, and the UrsaMajor supercluster, are among them. The probability that we obtain maxima like this from random distributions is lower than 0.001.Conclusions. Our results confirm that shell-like structures can be found in the distribution of nearby galaxies and their systems. The radii of the possible shells are larger than expected for a baryonic acoustic oscillations (BAO) shell (approximate to 109 h(-1) Mpc versus approximate to 120-130 h(-1) Mpc), and they are determined by very rich galaxy clusters and superclusters. In contrast, BAO shells are barely seen in the galaxy distribution. We discuss possible consequences of these differences

Measurement of Total and Differential Cross Sections of Neutrino and Antineutrino Coherent π±\pi^\pm Production on Carbon

Neutrino induced coherent charged pion production on nuclei, $\overline{\nu}_\mu A\to\mu^\pm\pi^\mp A$, is a rare inelastic interaction in which the four-momentum squared transfered to the nucleus is nearly zero, leaving it intact. We identify such events in the scintillator of MINERvA by reconstructing |t| from the final state pion and muon momenta and by removing events with evidence of energetic nuclear recoil or production of other final state particles. We measure the total neutrino and antineutrino cross sections as a function of neutrino energy between 2 and 20 GeV and measure flux integrated differential cross sections as a function of $Q^2$, $E_\pi$ and $\theta_\pi$. The $Q^2$ dependence and equality of the neutrino and anti-neutrino cross-sections at finite $Q^2$ provide a confirmation of Adler's PCAC hypothesis