A REVIEW ON ANATOMICAL AND SURGICAL IMPORTANCE OF MAMMARY GLAND

ABSTRACT The mammary gland is an exocrine gland present in female mammals responsible for the production and secretion of milk during the process of lactation. It is mainly composed by epithelial cells and adipocytes. The features that make mammary gland unique are 1) its highly plastic properties displayed during pregnancy, lactation and involution (all steps belonging to the lactation cycle) and 2) its requirement to grow in close association with adipocytes which are absolutely necessary to ensure mammary gland development at puberty and remodelling during the lactation cycle. (Georgia colleluori, Jessica perugini, Giorgio barbatelli, and saverio cintr (2021). Conclusion The knowledge about anatomical concepts helps for surgical treatmen

Self-nano Emulsifying Formulations: An Encouraging Approach for Bioavailability Enhancement and Future Perspective

Currently lipid-based formulations are playing a vital and promising role in improving the oral bioavailability of poorly water-soluble drugs. Lipid based formulations mainly consist of a drug dissolved in lipids such as triglycerides, glycerides, oils and surface active agent. Self nanoemulsifying formulations (SNEF) are isotropic mixtures of lipids/oils, surfactants and co-surfactants. On mild agitation followed by dilution in aqueous media, such as GI fluids, SNEF can form fine oil-in-water (o/w) nanoemulsions. Present chapter summarizes different types of lipid formulations with special emphasis on SNEF, availability of dosage forms, different components with natural surfactants from medicinal plants, mechanism of SNEF, recent advancements in oral drug delivery, solid SNEDDS, patents on SNEF and future prospects. SNEF emerging as powerful technique to improve solubility and commercialization of solid SNEF is the future novel drug delivery to improve bioavailability of poorly water soluble drugs

FLASH Irradiation Results in Reduced Severe Skin Toxicity Compared to Conventional-Dose-Rate Irradiation

Radiation therapy, along with surgery and chemotherapy, is one of the main treatments for cancer. While radiotherapy is highly effective in the treatment of localized tumors, its main limitation is its toxicity to normal tissue. Previous preclinical studies have reported that ultra-high dose-rate (FLASH) irradiation results in reduced toxicity to normal tissues while controlling tumor growth to a similar extent relative to conventional-dose-rate (CONV) irradiation. To our knowledge this is the first report of a dose-response study in mice comparing the effect of FLASH irradiation vs. CONV irradiation on skin toxicity. We found that FLASH irradiation results in both a lower incidence and lower severity of skin ulceration than CONV irradiation 8 weeks after single-fraction hemithoracic irradiation at high doses (30 and 40 Gy). Survival was also higher after FLASH hemithoracic irradiation (median survival >180 days at doses of 30 and 40 Gy) compared to CONV irradiation (median survival 100 and 52 days at 30 and 40 Gy, respectively). No ulceration was observed at doses 20 Gy or below in either FLASH or CONV. These results suggest a shifting of the dose-response curve for radiation-induced skin ulceration to the right for FLASH, compared to CONV irradiation, suggesting the potential for an enhanced therapeutic index for radiation therapy of cancer

A pH‐Triggered Polymer Degradation or Drug Delivery System by Light‐Mediated Cis / Trans Isomerization of o ‐Hydroxy Cinnamates

A new methodology for the pH-triggered degradation of polymers or for the release of drugs under visible light irradiation based on the cyclization of ortho-hydroxy-cinnamates (oHC) to coumarins is described. The key oHC structural motif can be readily incorporated into the rational design of novel photocleavable polymers via click chemistry. This main-chain moiety undergoes a fast photocleavage when irradiated with 455 nm light provided that a suitable base is added. A series of polyethylene glycol-alt-ortho-hydroxy cinnamate (polyethylene glycol (PEG)n-alt-oHC)-based polymers are synthesized and the time-dependent visible-light initiated cleavage of the photoactive monomer and polymer is investigated in solution by a variety of spectroscopic and chromatographic techniques. The photo-degradation behavior of the water-soluble poly(PEG2000-alt-oHC) is investigated within a broad pH range (pH = 2.1–11.8), demonstrating fast degradation at pH 11.8, while the stability of the polymer is greatly enhanced at pH 2.1. Moreover, the neat polymer shows long-term stability under daylight conditions, thus allowing its storage without special precautions. In addition, two water-soluble PEG-based drug-carrier molecules (mPEG2000-oHC-benzhydrol/phenol) are synthesized and used for drug delivery studies, monitoring the process by UV–vis spectroscopy in an ON/OFF intermittent manner

Abdominal FLASH irradiation reduces radiation-induced gastrointestinal toxicity for the treatment of ovarian cancer in mice

Radiation therapy is the most effective cytotoxic therapy for localized tumors. However, normal tissue toxicity limits the radiation dose and the curative potential of radiation therapy when treating larger target volumes. In particular, the highly radiosensitive intestine limits the use of radiation for patients with intra-abdominal tumors. In metastatic ovarian cancer, total abdominal irradiation (TAI) was used as an effective postsurgical adjuvant therapy in the management of abdominal metastases. However, TAI fell out of favor due to high toxicity of the intestine. Here we utilized an innovative preclinical irradiation platform to compare the safety and efficacy of TAI ultra-high dose rate FLASH irradiation to conventional dose rate (CONV) irradiation in mice. We demonstrate that single high dose TAI-FLASH produced less mortality from gastrointestinal syndrome, spared gut function and epithelial integrity, and spared cell death in crypt base columnar cells compared to TAI-CONV irradiation. Importantly, TAI-FLASH and TAI-CONV irradiation had similar efficacy in reducing tumor burden while improving intestinal function in a preclinical model of ovarian cancer metastasis. These findings suggest that FLASH irradiation may be an effective strategy to enhance the therapeutic index of abdominal radiotherapy, with potential application to metastatic ovarian cancer

UTILIZING VILLAGE WATER BODIES FOR POLYCULTURE OF FISH AND PRAWN: ROLE OF INPUTS IN PRODUCTION ENHANCEMENT

A field study on participatory technology development (PTD) approaches was taken up in the southern transitional zone (Zone 7) of Karnataka in village water bodies leased by the Grama Panchayat. Polyculture of Indian Major Carps catla and rohu with freshwater prawn Macrobrachium rosenbergii was investigated. The experimental water bodies were of the size 0.8 to 1.0 ha, having an average depth of 1.8 m to 2 m. After observing pre-stocking management measures, the water bodies were stocked with fingerlings of catla and rohu at 0.5 /m2each and juveniles of prawn at1/m2. In T1, replicate water bodies received cow dung as manure at 6 t/ha, applied in split doses of 375 kg once every fortnight and the fish were fed at the rate of 3% of body weight daily in the morning hours. Water bodies receiving only cow dung at 6t/ha were designated T2. Two water bodies without either of the inputs served as the control and were designated as T3. The average total production in T1 treatment was significantly higher at 3401.40 kg/ha compared to T2 and T3, which recorded 1674.25 kg/ha and 975.75 kg/ha production respectively. Production of the prawn was 544.50 kg/ha, 146.75 kg/ha and 45.25 kg/ha in T1, T2, and T3 treatments. The average survival rate of fish was 83.41%, 54.39%, and 32.16%, while that of the prawn was 64.55%, 34.65% and 28.6% respectively. The study indicates that use of manure and feed in polyculture of fish and prawns could be a viable strategy for enhancing productivity and profitability in village water bodies

Media management in India in the new millennium: An overview

During the last three decades, globalization has affected the media regionally, nationally and internationally. There is commendable expansion of media across the world in the age of globalization. Multi-national corporations have established the media institutions which have become instrument of profit making in the age of globalization. India adopted new economic policy in 1990-91 under the leadership of P.V.Narasimharao and Manmohan Singh. India and China have become prominent economic players in the Asian continent over a period of time. The process of globalisation has definitely affected the media scenario of the country. The impact of globalization on the management of media in India has been examined systematically in the present study

Active Control of Resonant Cloaking in a Terahertz MEMS Metamaterial

10.1002/adom.201800141Advanced Optical Materials6161800141-180014