648 research outputs found
Statistical stability and limit laws for Rovella maps
We consider the family of one-dimensional maps arising from the contracting
Lorenz attractors studied by Rovella. Benedicks-Carleson techniques were used
by Rovella to prove that there is a one-parameter family of maps whose
derivatives along their critical orbits increase exponentially fast and the
critical orbits have slow recurrent to the critical point. Metzger proved that
these maps have a unique absolutely continuous ergodic invariant probability
measure (SRB measure).
Here we use the technique developed by Freitas and show that the tail set
(the set of points which at a given time have not achieved either the
exponential growth of derivative or the slow recurrence) decays exponentially
fast as time passes. As a consequence, we obtain the continuous variation of
the densities of the SRB measures and associated metric entropies with the
parameter. Our main result also implies some statistical properties for these
maps.Comment: 1 figur
Specific defect in N-acetylglucosamine incorporation in the biosynthesis of the glycosylphosphatidylinositol anchor in cloned cell lines from patients with paroxysmal nocturnal hemoglobinuria.
Invariant manifolds and equilibrium states for non-uniformly hyperbolic horseshoes
In this paper we consider horseshoes containing an orbit of homoclinic
tangency accumulated by periodic points. We prove a version of the Invariant
Manifolds Theorem, construct finite Markov partitions and use them to prove the
existence and uniqueness of equilibrium states associated to H\"older
continuous potentials.Comment: 33 pages, 6 figure
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Digitizing mass spectrometry data to explore the chemical diversity and distribution of marine cyanobacteria and algae.
Natural product screening programs have uncovered molecules from diverse natural sources with various biological activities and unique structures. However, much is yet underexplored and additional information is hidden in these exceptional collections. We applied untargeted mass spectrometry approaches to capture the chemical space and dispersal patterns of metabolites from an in-house library of marine cyanobacterial and algal collections. Remarkably, 86% of the metabolomics signals detected were not found in other available datasets of similar nature, supporting the hypothesis that marine cyanobacteria and algae possess distinctive metabolomes. The data were plotted onto a world map representing eight major sampling sites, and revealed potential geographic locations with high chemical diversity. We demonstrate the use of these inventories as a tool to explore the diversity and distribution of natural products. Finally, we utilized this tool to guide the isolation of a new cyclic lipopeptide, yuvalamide A, from a marine cyanobacterium
Statistical Consequences of Devroye Inequality for Processes. Applications to a Class of Non-Uniformly Hyperbolic Dynamical Systems
In this paper, we apply Devroye inequality to study various statistical
estimators and fluctuations of observables for processes. Most of these
observables are suggested by dynamical systems. These applications concern the
co-variance function, the integrated periodogram, the correlation dimension,
the kernel density estimator, the speed of convergence of empirical measure,
the shadowing property and the almost-sure central limit theorem. We proved in
\cite{CCS} that Devroye inequality holds for a class of non-uniformly
hyperbolic dynamical systems introduced in \cite{young}. In the second appendix
we prove that, if the decay of correlations holds with a common rate for all
pairs of functions, then it holds uniformly in the function spaces. In the last
appendix we prove that for the subclass of one-dimensional systems studied in
\cite{young} the density of the absolutely continuous invariant measure belongs
to a Besov space.Comment: 33 pages; companion of the paper math.DS/0412166; corrected version;
to appear in Nonlinearit
Patients with paroxysmal nocturnal hemoglobinuria have a high frequency of peripheral-blood T cells expressing activating isoforms of inhibiting superfamily receptors
Patients with paroxysmal nocturnal hemoglobinuria (PNH) have a large clonal population of blood cells deriving from hematopoietic stem cells (HSCs) deficient in glycosylphosphatidylinositol (GPI)-anchored surface molecules. A current model postulates that PNH arises through negative selection against normal HSCs exerted by autoreactive T cells, whereas PNH HSCs escape damage. We have investigated the inhibitory receptor superfamily (IRS) system in 13 patients with PNH. We found a slight increase in the proportion of T cells expressing IRS. In contrast to what applies to healthy donors, the engagement of IRS molecules on T cells from patients with PNH elicited a powerful cytolytic activity in a redirected killing assay, indicating that these IRSs belong to the activating type. This was confirmed by clonal analysis: 50% of IRS+ T-cell clones in patients with PNH were of the activating type, while only 5% were of the activating type in healthy donors. Moreover, the ligation of IRS induces (1) production of tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) and (2) brisk cytolytic activity against cells bearing appropriate IRS counter-ligands. In addition, these IRS+ T cells show natural killer (NK)-like cytolytic activity to which GPI- cells were less sensitive than GPI+ cells. Thus, T cells with NK-like features, expressing the activating isoforms of IRS, may include effector cells involved in the pathogenesis of PNH
Slip on three-dimensional surfactant-contaminated superhydrophobic gratings
Trace amounts of surfactants have been shown to critically prevent the drag
reduction of superhydrophobic surfaces (SHSs), yet predictive models including
their effects in realistic geometries are still lacking. We derive theoretical
predictions for the velocity and resulting slip of a laminar fluid flow over
three-dimensional SHS gratings contaminated with surfactant, which allow for
the first direct comparison with experiments. The results are in good agreement
with our numerical simulations and with measurements of the slip in
microfluidic channels lined with SHSs, which we obtain via confocal microscopy
and micro-particle image velocimetry. Our model enables the estimation of a
priori unknown parameters of surfactants naturally present in applications,
highlighting its relevance for microfluidic technologies.Comment: 6 pages, 3 figures, 11 supplemental pages, 2 supplemental figure
Kernicterus by glucose-6-phosphate dehydrogenase deficiency: a case report and review of the literature
<p>Abstract</p> <p>Introduction</p> <p>Glucose-6-phosphate dehydrogenase deficiency is an X-linked recessive disease that causes acute or chronic hemolytic anemia and potentially leads to severe jaundice in response to oxidative agents. This deficiency is the most common human innate error of metabolism, affecting more than 400 million people worldwide.</p> <p>Case presentation</p> <p>Here, we present the first documented case of kernicterus in Panama, in a glucose-6-phosphate dehydrogenase-deficient newborn clothed in naphthalene-impregnated garments, resulting in reduced psychomotor development, neurosensory hypoacousia, absence of speech and poor reflex of the pupil to light.</p> <p>Conclusion</p> <p>Mutational analysis revealed the glucose-6-phosphate dehydrogenase Mediterranean polymorphic variant, which explained the development of kernicterus after exposition of naphthalene. As the use of naphthalene in stored clothes is a common practice, glucose-6-phosphate dehydrogenase testing in neonatal screening could prevent severe clinical consequences.</p
Polymorphic sites in the African population detected by sequence analysis of the glucose-6-phosphate dehydrogenase gene outline the evolution of the variants A and A-.
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