Infected pancreatic necrosis: outcomes and clinical predictors of mortality. A post hoc analysis of the MANCTRA-1 international study

: The identification of high-risk patients in the early stages of infected pancreatic necrosis (IPN) is critical, because it could help the clinicians to adopt more effective management strategies. We conducted a post hoc analysis of the MANCTRA-1 international study to assess the association between clinical risk factors and mortality among adult patients with IPN. Univariable and multivariable logistic regression models were used to identify prognostic factors of mortality. We identified 247 consecutive patients with IPN hospitalised between January 2019 and December 2020. History of uncontrolled arterial hypertension (p = 0.032; 95% CI 1.135-15.882; aOR 4.245), qSOFA (p = 0.005; 95% CI 1.359-5.879; aOR 2.828), renal failure (p = 0.022; 95% CI 1.138-5.442; aOR 2.489), and haemodynamic failure (p = 0.018; 95% CI 1.184-5.978; aOR 2.661), were identified as independent predictors of mortality in IPN patients. Cholangitis (p = 0.003; 95% CI 1.598-9.930; aOR 3.983), abdominal compartment syndrome (p = 0.032; 95% CI 1.090-6.967; aOR 2.735), and gastrointestinal/intra-abdominal bleeding (p = 0.009; 95% CI 1.286-5.712; aOR 2.710) were independently associated with the risk of mortality. Upfront open surgical necrosectomy was strongly associated with the risk of mortality (p < 0.001; 95% CI 1.912-7.442; aOR 3.772), whereas endoscopic drainage of pancreatic necrosis (p = 0.018; 95% CI 0.138-0.834; aOR 0.339) and enteral nutrition (p = 0.003; 95% CI 0.143-0.716; aOR 0.320) were found as protective factors. Organ failure, acute cholangitis, and upfront open surgical necrosectomy were the most significant predictors of mortality. Our study confirmed that, even in a subgroup of particularly ill patients such as those with IPN, upfront open surgery should be avoided as much as possible. Study protocol registered in ClinicalTrials.Gov (I.D. Number NCT04747990)

Genetic diversity and phylogeographic structure of sixteen Mediterranean chicken breeds assessed with microsatellites and mitochondrial DNA

The genetic diversities and relationships among 16 local breeds of chicken originating from five countries (Italy, Spain, Serbia, Albania and Republic of Malta) within the Mediterranean basin were assessed by sequencing part of the mitochondrial DNA (mtDNA) D-loop region and by genotyping individuals at 27 autosomal microsatellite loci. The aim was to study the microevolution of chicken on the northern shores of the Mediterranean and to determine their present genetic status. A 506bp fragment of the mtDNA control region was sequenced in 160 individual DNA samples. The mtDNA sequence polymorphisms nomenclature that is normally used in these studies suggests that the Mediterranean chicken breeds under investigation are related to haplogroup E. A total of 465 blood samples were collected and utilised for microsatellite analysis. Six breeds (Ancona, Livornese Bianca-Italy; Pita Pinta Asturiana, Gallina de Sobrarbe-Spain; Albanian population-Albania; and the Maltese Black-Malta) showed significant high levels of inbreeding. About 22% of the total genetic variation observed was due to variability between populations. STRUCTURE analysis confirmed the breed variability result (FST=0.22) also observed in the Neighbor-Net dendrogram

Genetic diversity and phylogeographic structure of sixteen Mediterranean chicken breeds assessed with microsatellites and mitochondrial DNA

The genetic diversities and relationships among 16 local breeds of chicken originating from five countries (Italy, Spain, Serbia, Albania and Republic of Malta) within the Mediterranean basin were assessed by sequencing part of the mitochondrial DNA (mtDNA) D-loop region and by genotyping individuals at 27 autosomal microsatellite loci. The aim was to study the microevolution of chicken on the northern shores of the Mediterranean and to determine their present genetic status. A 506 bp fragment of the mtDNA control region was sequenced in 160 individual DNA samples. The mtDNA sequence polymorphisms nomenclature that is normally used in these studies suggests that the Mediterranean chicken breeds under investigation are related to haplogroup E. A total of 465 blood samples were collected and utilised for microsatellite analysis. Six breeds (Ancona, Livornese Bianca-Italy; Pita Pinta Asturiana, Gallina de Sobrarbe-Spain; Albanian population-Albania; and the Maltese Black Malta) showed significant high levels of inbreeding. About 22% of the total genetic variation observed was due to variability between populations. STRUCTURE analysis confirmed the breed variability result (F-ST=0.22) also observed in the Neighbor-Net dendrogram. These results strongly allude that the 16 Mediterranean chicken breeds studied originated from three distinct maternal lineages and retain moderate levels of autosomal genetic diversity. (C) 2015 Elsevier B.V. All rights reserved

Association of common genetic variants with risperidone adverse events in a Spanish schizophrenic population

Risperidone non-compliance is often high due to undesirable side effects, whose development is in part genetically determined. Studies with genetic variants involved in the pharmacokinetics and pharmacodynamics of risperidone have yielded inconsistent results. Thus, the aim of this study was to investigate the putative association of genetic markers with the occurrence of four frequently observed adverse events secondary to risperidone treatment: sleepiness, weight gain, extrapyramidal symptoms and sexual adverse events. A series of 111 schizophrenia inpatients were genotyped for genetic variants previously associated with or potentially involved in risperidone response. Presence of adverse events was the main variable and potential confounding factors were considered. Allele 16Gly of ADRB2 was significantly associated with a higher risk of sexual adverse events. There were other non-significant trends for DRD3 9Gly and SLC6A4 S alleles. Our results, although preliminary, provide new candidate variants of potential use in risperidone safety prediction.This study was supported by Fondo de Investigation Sanitaria (FIS) EC07/90393, EC07/90466 and EC07/90604 Grants. Berta Almoguera's work is supported by a Rio Hortega Grant from Instituto de Salud Carlos III. Pedro Dorado is supported by Instituto de Salud Carlos III-FIS and European Union (FEDER) Grant CP06/00030. The contribution from the Extremadura group is coordinated in the frame of the Iberoamerican Network of PharmacogeneticsPeer reviewe

Anales de Edafología y Agrobiología Tomo 37 Número 11-12

Estudio mineralógico de las arcillas de Andepts, en una secuencia cronológica, mediante microscopía electrónica, por C. Rodríguez Pascual, J. Galván, M. L. Tejedor-Salguero y E. Fenández-Caldas.-- Determinaciones analíticas en suelos. Normalización de métodos : Densidad real, por el Grupo de Trabajo de Normalización de Métodos Analíticos y la Subcomisión de Física de Suelos.-- Suelos volcánicos españoles. l. Canarias. Características morfológicas y químicas, por C. Vizcayno Muiñoz, J. García Vicente y M. T. García González.--Suelos volcánicos españoles. II. Canarias. Mineralogía de la fracción arcilla, por C. Vizcayno Muñoz, M. T. García Gonzáles y J. García Vicente.-- Estudio de un Ranker de la provincia de Burgos. I. Descripción, caracterización de arcillas y dinámica del Al, Ca y Fe durante el proceso de extracción de los compuestos húmicos, por S. Gonsález Carcedo.--- Estudio de un Ranker de la provincia de Burgos. II. Distribución de ácidos húmicos en las diferentes fracciones físicas, por S. Gonsález Carcedo y S. Bruckert.-- Nota adicional : Precisiones sobre la presencia de gibsita en suelos del Oeste de España, por J. Saavedra, J. F. Gallardo, A. García Sánchez y M. Sánchez Camazano.-- Influjo del ion Mg++ en la evolución del ortofosfato dicálcico dihidra.to en medios acuosos, por F. González García, J. García de Leániz y J. A. Pinilla.-- Método para a medida de actividades de iones en suspensiones de arcillas por potenciometría diferencial, por Rafael Llorca Llorca.-- Gradient elution of soil phosphates. A review, by L. L. Somani.-- Observaciones sobre las pérdidas de flores y frutos jóvenes en el olivo «manzanillo» en Sevilla, por A. Troncoso, J. Prieto y J. Liñán.-- Contribución al estudio de la platanera canaria. Estomas y su distribución en la epidermis foliar por C. D. Lorenzo Bethencourt, C. Prendes Ayala, M. A. Rodríguez Raymond y A. C. Blesa Rodríguez.-- Influencia de disolventes amoniacales sobre productos de degradación del ácido 3-indolacético, por M. Cuello Moreno, M. Acosta Echevarría, J. Sánchez Bravo y F. Sabater García.-- The Negev ecosystem model, by J. Katznelson.-- Somne interactions in biological system, by Joseph Katznelson.-- Nota previa. Estudio por Sem y Edax de las variaciones en la estructura de suelos como consecuencia de la aplicación de paja, por M. T. Martín Patino y V. Hernando Fernández.-- Estudios recapitulativos.--Estudio crítico de la producción de etileno por microorganismos del suelo e implicaciones de esta fitohormona en las interacciones microbio-planta,por J. M. Barca y D. N. Rodríguez-Navarro.—Notas.-- Reunión de la Comisión VII de la Sociedad Española de Ciencia del Suelo 1193 Primer Cursillo Nacional sobre Micromorfología de Suelos 1194 IV Simposio Na.cional de Bioclimatología.--International Working-Meeting on Soil Micromorphology 1195 Conferencia del Dr. Díaz-Fierros.-- Conferencia del Prof. Millot .-- Real Academia de Farmacia.-- Convocatoria de becas postdoctorales del C. S. l. C.-- VII Premio Nacional de Publicaciones Agrarias.-- Bibliografía.Peer reviewe

High-resolution spatio-temporal analyses of drought episodes in the western Mediterranean basin (Spanish mainland, Iberian Peninsula)

12 Pags.- 6 Figs.- 1 Tabl. © The Author(s) 2018. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The purpose of this research was to identify major drought events on the Spanish mainland between 1961 and 2014 by means of two drought indices, and analyze the spatial propagation of drought conditions. The indices applied were the standardized precipitation index (SPI) and the standardized evaporation precipitation index (SPEI). The first was calculated as standardized anomalies of precipitation at various temporal intervals, while the second examined the climatic balance normalized at monthly scale, incorporating the relationship between precipitation and the atmospheric water demand. The daily meteorological data from Spanish Meteorological Archives (AEMet) were used in performing the analyses. Within the framework of the DESEMON project, original data were converted into a high spatial resolution grid (1.1 km2) following exhaustive quality control. Values of both indices were calculated on a weekly scale and different timescales (12, 24 and 36 months). The results show that during the first half of the study period, the SPI usually returned a higher identification of drought areas, while the reverse was true from the 1990s, suggesting that the effect from atmospheric evaporative demand could have increased. The temporal propagation from 12- to 24-month and 36-month timescales analyzed in the paper seems to be a far from straightforward phenomenon that does not follow a simple rule of time lag, because events at different temporal scales can overlap in time and space. Spatially, the propagation of drought events affecting more than 25% of the total land indicates the existence of various spatial gradients of drought propagation, mostly east–west or west–east, but also north–south have been found. No generalized episodes were found with a radial pattern, i.e., from inland to the coast.This work is supported by the projects CGL2014-52135-C03-01, CGL2014-52135-C3-3-R and PCIN-2015-220, financed by the Spanish Government, Ministry of the Economy and Finance and FEDER, IMDROFLOOD financed by the Water Works 2014 co-funded call of the European Commission, INDECIS, financed by the ERA-NET Cofund for Climate Services of the European Research Area for Climate Services, and the Regional Government of Aragón DGA-FSE (Grupo de Investigación Consolidado ‘Clima, Agua, Cambio Global y Sistemas Naturales’). Celia Salinas is a FPI-PhD student supported by the Ministry of the Economy and Finance. Miquel Tomas-Burguera was supported by the predoctoral FPU program 2013 (Ministry of Education, Culture and Sport).Peer reviewe

Anales de Edafología y Agrobiología Tomo 47 Número 7-8

l. Suelos. Química. Estudio de los suelos de la depresión Guadix-Baza (Granada). II. Análisis de factores en modo R. Por A. lriarte Mayo, A . Pozzuoli y E. Barahona Fernández. Revisión del método de determinación automatizada de nitrógeno U. V. oxidable en extractos de suelos. Por J. A. Díez.-- Biología Consideraciones ecológicas y bioquímicas sobre la humificación en sabinares desarrollados sobre material calizo y gneísico. Por M. R. Rodríguez y F. Velasco.-- Génesis, Clasificación y Cartografía Suelos, geología y geomorfología en zonas erosionadas de la cuenca del Valdeamargos, depresión de Calatayud. Por M. A. Mulders, J. Slurink y J. Boixadera.-- Aplicación de la metodología de la cartografía básica a la comarca La Plana de Requena-Utiel (Valencia). Por R. Boluda Hernández, M. Moraleda Esteve, V. Andréu Pérez y J. Sánchez Díaz.-- Estudio de caracterización de minerales (fracción arena) en suelos gleicos de una zona semiárida. Por Mª P. García Rodríguez, J. Fortéza Bonnin, A. García Rodríguez y L. F. Lorenzo Martín, con la colaboración técnica de N. Najac Ballesteros.-- Clasificación de sectores ecológicos en la sierra del Negrete y Utiel (Valencia), utilizando el sensor thematic mapper del satélite Landsat-5. Por R. Boluda Hernández.-- Unidades de paisaje en el tercio norte del valle de Ayora (Valencia, España). Por J. A. Hernandez y J. L. Rubio.-- Suelos de la Isla de Gomera (1. Canarias). l. Vertiente septentrional. Características morfológicas, físico-químicas, mineralógicas, micromorfológicas, clasificación e interpretación. Por C. Jiménez Mendoza, M. L. Tejedor Salguero y A. Rodríguez Rodríguez.-- Suelos de la Isla de Gomera (1. Canarias). 11. Vertiente meridfonal. Ecología, Características morfológicas, físico-químicas, mineralógicas. micromorfológicas, clasificación e interpretación. Por C. Jiménez Mendoza, A. Rodrr'guez Rodríguez y M. L. Tejedor Salguero.--. Fertilidad Efecto de fertilizantes orgánicos sobre el cultivo de patatas y sobre las propiedades del suelo. Por J. A. Haroun Tabraue y E. Hernández.-- II. Biología Vegetal-Nutrición. Influencia del sistema de nutrición en la calidad de los frutos de tomate. l. Rendimientos, parámetros físicos, fracciones nitrogenadas, acidez y azúcares. Por F.J. López-Andréu, R . M. Esteban, E. Molla y O. Carpena.-- Influencia del sistema de nutrición en la calidad de los frutos de tomate. 11. Caro- tenoides, ácido ascórbico, sustancias pécticas y Flavonoides. Por F. J. López- Andréu, R. M. Esteban, E. Molla y O. Carpena.-- Fisiología Efecto de tres cultivares en el vigor de semillas de girasol. Por M. Torres y C. J. Martínez-Honduvilla.-- Agro biología Effect of qualities of irrigation water and N P K fertilizers on soil properties. Por P. Lal and R. Lal.-- Modelos estructurales condicionados por el arbolado en comunidades de diferente trofismo. Por A. Puerto, J. A. Garcra, M. D. Matías, J. A. Saldaña y C. Pérez.-- III. Trabajo recapitulativo. Relación entre el contenido de¡olifenoles y actividad fotosintéticas bajo radiación ultravioleta. PorJ. Baztan y RuanoPeer reviewe