Journal of Pre-College Engineering Education Research (J-PEER) Annual Report from January 1, 2022, to December 31, 2022

In this annual report, we present our reflections on 2022 along with the Journal of Pre-College Engineering Education Research (JPEER) readership trends and authorship metrics. In 2022, J-PEER published two issues in volume 12 comprised of 17 articles. The second issue of the year included a special issue on the impact of COVID-19 on education, marking the impact that the pandemic had on pre-college engineering education

Montgomery 1960: Using Technology to Teach Empathy and Perspective Taking

A primary purpose of higher education in the U.S. is to promote personally and socially responsible graduates that can lead at work and in society (AAC&U, 2005). To successfully do so, students need coaching that intentionally develops empathy, perspective taking, intercultural agility, and the capacity to make ethical decisions (Narveaz, 2006). The holistic approaches historically used to teach these skills died with classical curriculum as the research university emerged and the risk-management culture replaced our in loco parentis relationships with students (Colby & Eichman. 2005). The current legal and political climate limits genuine discussion between college students and faculty/staff mentors about how to face the ethical and intercultural challenges presented by college life and emerge a leader (Bickel & Lake, 1998). Yet colleges still need to facilitate personal and social responsibility education and coach students to use these skills to lead. The use of gamification technology can be used to promote the higher order skill development needed by college students to meet the leadership challenges of tomorrow - empathy, perspective taking, intercultural agility, and ethical decision-making. This poster presentation introduces Experience 1960 Montgomery, Alabama (an ARIS Online Virtual Reality App) that immerses the participant in the lived historical experiences of the college student leaders as they navigate the events that became the Dixon v. State of Alabama court case. This technological platform allows participants to engage with the decisions, actions, and perspectives of the governmental officials, college administrators, and student demonstrators during the 1960s student sit-ins for Civil Rights in Montgomery, Alabama. The historical leadership case study allows participants to see themselves in each of the moral leader comparators lived experiences as told by them and see the original documents and newspaper coverage of the events. The events selected for this pilot spawned two landmark legal cases—the Dixon v. Alabama State Board of Education (1961) extending due process rights to students and the Sullivan v. NY Times (1964) requiring malice for journalists to libel public officials. In addition to enhancing the delivery of ELPS 351: Personally and Socially Responsible Leadership, completion of this project will provide valuable classroom and student leader training, as it aids in student understanding of the contextual factors influencing administrator and legislator action

Retinoic acid inhibition impairs planarian eye regeneration

Retinoic acid is a known morphogen in regulating animal growth and development. Planaria are a key model system for regeneration and their eyes are a morphological marker of anterior differentiation. We explored the requirement for retinoic acid signaling in the regeneration of body parts in the planaria S. mediterranea using an inhibitor of retinoic acid synthesis, diethylaminobenzaldehyde (DEAB). Whole planaria, soaked in DEAB for three days prior to and five days following amputation, produced trunk and tail fragments with defective anterior regeneration. Following regeneration, up to 80% of posterior fragments developed abnormal eyes. The abnormalities included animals without eyes, with only a single eye, with one enlarged eye, or two eyes of different sizes. Eyes were considered to be functional because animals responded to blue laser light with turning behavior. No abnormalities in eye regeneration were observed in side by side vehicle controls. These results suggest that retinoic acid is necessary for normal eye regeneration following injury and supports a previously undocumented signaling role in planaria eye development

Subglacial topography and geothermal heat flux: potential interactions with drainage of the Greenland ice sheet

This is the published version, also available here: http://dx.doi.org/10.1029/2007GL030046.[1] Many of the outlet glaciers in Greenland overlie deep and narrow trenches cut into the bedrock. It is well known that pronounced topography intensifies the geothermal heat flux in deep valleys and attenuates this flux on mountains. Here we investigate the magnitude of this effect for two subglacial trenches in Greenland. Heat flux variations are estimated for idealized geometries using solutions for plane slopes derived by Lachenbruch (1968). It is found that for channels such as the one under Jakobshavn Isbræ, topographic effects may increase the local geothermal heat flux by as much as 100%

A Xenopus oocyte model system to study action potentials

Action potentials (APs) are the functional units of fast electrical signaling in excitable cells. The upstroke and downstroke of an AP is generated by the competing and asynchronous action of Na+- and K+-selective voltage-gated conductances. Although a mixture of voltage-gated channels has been long recognized to contribute to the generation and temporal characteristics of the AP, understanding how each of these proteins function and are regulated during electrical signaling remains the subject of intense research. AP properties vary among different cellular types because of the expression diversity, subcellular location, and modulation of ion channels. These complexities, in addition to the functional coupling of these proteins by membrane potential, make it challenging to understand the roles of different channels in initiating and temporally shaping the AP. Here, to address this problem, we focus our efforts on finding conditions that allow reliable AP recordings from Xenopus laevis oocytes coexpressing Na+ and K+ channels. As a proof of principle, we show how the expression of a variety of K+ channel subtypes can modulate excitability in this minimal model system. This approach raises the prospect of studies on the modulation of APs by pharmacological or biological means with a controlled background of Na+ and K+ channel expression

Improving the Quality of Child Care in the Rural South

A collaborative of six social service agencies and a state university determined that the single most pressing need of families in a 14-county, rural area was child care. The Training Resource Center, developed through a W K. Kellogg Foundation grant, worked with day care licensing and early childhood professional groups to develop a plan to address the systemic nature of the problem of how to improve the quality of child care. Programs developed included training, mentoring, NAEYC accreditation, and a resource library. After 15 months, some programs show the possibility of sustainability

Retigabine holds KV7 channels open and stabilizes the resting potential

The anticonvulsant Retigabine is a KV7 channel agonist used to treat hyperexcitability disorders in humans. Retigabine shifts the voltage dependence for activation of the heteromeric KV7.2/KV7.3 channel to more negative potentials, thus facilitating activation. Although the molecular mechanism underlying Retigabine\u27s action remains unknown, previous studies have identified the pore region of KV7 channels as the drug\u27s target. This suggested that the Retigabine-induced shift in voltage dependence likely derives from the stabilization of the pore domain in an open (conducting) conformation. Testing this idea, we show that the heteromeric KV7.2/KV7.3 channel has at least two open states, which we named O1 and O2, with O2 being more stable. The O1 state was reached after short membrane depolarizations, whereas O2 was reached after prolonged depolarization or during steady state at the typical neuronal resting potentials. We also found that activation and deactivation seem to follow distinct pathways, suggesting that the KV7.2/KV7.3 channel activity displays hysteresis. As for the action of Retigabine, we discovered that this agonist discriminates between open states, preferentially acting on the O2 state and further stabilizing it. Based on these findings, we proposed a novel mechanism for the therapeutic effect of Retigabine whereby this drug reduces excitability by enhancing the resting potential open state stability of KV7.2/KV7.3 channels. To address this hypothesis, we used a model for action potential (AP) in Xenopus laevis oocytes and found that the resting membrane potential became more negative as a function of Retigabine concentration, whereas the threshold potential for AP firing remained unaltered