Structural Changes Of Dha-Containing Phospholipids By K+ And Na+ Cations In Nerve Cell Membranes

Understanding the structure and dynamics of a docosa hexaenoic acid (DHA) containing phospholipid monomer within membranes is essential for recognizing the bilayer function in central nervous system. It has been recognized that the electrical impulses in nerve cells arise from the movement of electrical charges in the form of ions across the plasma membrane. In this study, we have modeled a novel DHA-containing phosphatidylcholine (PC) found in a marine single cell eukaryote, >Schizochytrium sp F26-b> and we were focused on understanding the physico-chemical nature of K+ and Na+ movement toward DHA-containing phospholipid through its structural changes. To know more about the temperature dependence of the structural stability of 1-pentadecanoyl-2-docosahexaenoyl-sn-glycerol-3-phosphocholin frequently calculations have been carried out at different biological temperatures and the plotted graphs of energy values at all employed temperatures have been analyzed. Our findings confirmed the usefulness of Quantum chemical calculations for determination of dynamics of a phospholipid and prediction of their biological activity in bio-membranes.Chemistr

The Mid-Term Changes of Pulmonary Function Tests After Phrenic Nerve Transfer

Background: In the restoration of elbow flexion, the phrenic nerve has proven to be a good donor, but considering the role of the phrenic nerve in respiratory function, we cannot disregard the potential dangers of this method. Objectives: In the current study, we reviewed the results of pulmonary function tests (PFT) in four patients who underwent phrenic nerve transfer. Patients and Methods: We reviewed the results of serial spirometry tests, which were performed before and after phrenic nerve transfer surgery. Results: All patients regained Biceps power to M3 strength or above. None of our patients experienced pulmonary problems or respiratory complaints, but a significant reduction of spirometric parameters occurred after surgery. Conclusions: This study highlights the close link between the role of the phrenic nerve and pulmonary function, such that the use of this nerve as a transfer donor leads to spirometric impairments

Detection of human papillomavirus DNA in intraosseus ameloblastoma

Human Papillomavirus (HPV) infection has been shown as a risk factor in oral carcinogenesis. The association between HPV and benign and malignant neoplasm of oral mucosa, especially surface epithelium-derived tumors, is well established. The role of HPV in pathogenesis of odontogenic cysts and tumors has been published in few articles. The aim of this study was detection of HPV in Iranian patients with intrabony ameloblastoma and investigation of specific risk factors associated with ameloblastoma. One hundred intrabony ameloblastoma and 50 age-sex matched samples as controls were evaluated by polymerase chain reaction for the detection and typing of HPV. Fisher exact and chi square tests were used to assess the data. HPV DNA was detected in 32% of patients and 10% of controls. HPV-6 was the most prevalent genotype (31.6%) in infected cases. It was followed by HPV-11 (12.5%), HPV-16 (12.5%) and HPV-31 (3.1%). We found a significant association between presence of HPV and location of tumor (p = 0.02), traumatic history (p = 0.03) and ododontic therapy (p = 0.01). These findings indicated that HPV-6 probably is one of the most important etiologic agents in causing intraosseous ameloblastoma in Iranian population. © 2006 Academic Journals Inc., USA

Sharing your assets? A holistic review of the sharing economy

Even though academics and practitioners extensively apply the notion of the sharing economy (SE), the conceptualization and the literature construction remained disjointed and dispersed due to the lack of a rigorous attempt to understand the core concept of the SE. This concept is multidimensional, which makes its investigation essential for practitioners and academics. Based on a 15-year data set collected from the Web of Science database, our paper seeks to provide a pervasive science plot of the intellectual structure of the SE field. A bibliometric review method was used by studying documents published from 2005 to 2020, using the VOSviewer, Bibexcel, SPSS, and GunnMap2 software. Providing an overview of articles, authors, the most influential journals, and themes of research, we contribute to the literature on the SE by identifying and proposing six research groups in MDS analysis, six research clusters in HCA analysis, and future study directions. Eventually, the research acknowledges the theoretical contribution, the limits of the present study, and recommends further study directions

Spontaneous Regeneration of the Mandible after Hemimandibulectomy: Report of a Case

Mandibular defects may result from many conditions such as trauma, inflammatory diseases and tumors. There are rare cases reported in the literature that have demonstrated spontaneous bone regeneration after resection of the mandible. Several factors such as age, preservation of the periosteum and genetics seem to influence spontaneous bone regeneration capacity in individuals. Evaluation of these factors may lead to a better understanding of the mechanism of spontaneous bone regeneration and also help to create new methods for bone reconstruction. The purpose of this article was to describe the spontaneous regeneration of the hemi-mandible with a well shaped condyle and coronoid after resecting a mandibular pathologic lesion in a young man

A Gravitational Search Algorithm-Based Single-Center of Mass Flocking Control for Tracking Single and Multiple Dynamic Targets for Parabolic Trajectories in Mobile Sensor Networks

Developing optimal flocking control procedure is an essential problem in mobile sensor networks (MSNs). Furthermore, finding the parameters such that the sensors can reach to the target in an appropriate time is an important issue. This paper offers an optimization approach based on metaheuristic methods for flocking control in MSNs to follow a target. We develop a non-differentiable optimization technique based on the gravitational search algorithm (GSA). Finding flocking parameters using swarm behaviors is the main contributing of this paper to minimize the cost function. The cost function displays the average of Euclidean distance of the center of mass (COM) away from the moving target. One of the benefits of using GSA is its application in multiple targets tracking with satisfying results. Simulation results indicate that this scheme outperforms existing ones and demonstrate the ability of this approach in comparison with the previous methods

Simultaneous impact of atorvastatin and mesenchymal stem cells for glioblastoma multiform suppression in rat glioblastoma multiform model

Glioblastoma multiform (GBM) is known as an aggressive glial neoplasm. Recently incorporation of mesenchymal stem cells with anti-tumor drugs have been used due to lack of immunological responses and their easy accessibility. In this study, we have investigated the anti-proliferative and apoptotic activity of atorvastatin (Ator) in combination of mesenchymal stem cells (MSCs) on GBM cells in vitro and in vivo. The MSCs isolated from rats and characterized for their multi-potency features. The anti-proliferative and migration inhibition of Ator and MSCs were evaluated by MTT and scratch migration assays. The annexin/PI percentage and cell cycle arrest of treated C6 cells were evaluated until 72 h incubation. The animal model was established via injection of C6 cells in the brain of rats and subsequent injection of Ator each 3 days and single injection of MSCs until 12 days. The growth rate, migrational phenotype and cell cycle progression of C6 cells decreased and inhibited by the interplay of different factors in the presence of Ator and MSCs. The effect of Ator and MSCs on animal models displayed a significant reduction in tumor size and weight. Furthermore, histopathology evaluation proved low hypercellularity and mitosis index as well as mild invasive tumor cells for perivascular cuffing without pseudopalisading necrosis and small delicate vessels in Ator + MSCs condition. In summary, Ator and MSCs delivery to GBM model provides an effective strategy for targeted therapy of brain tumor. © 2020, The Author(s)

Development of Carbon Emission Assessment Tool Towards Promoting Sustainability in Cal State LA

The great demand for the burning of fossil fuels has greatly increased greenhouse gases (GHG) concentrations in the atmosphere. An increase in the atmospheric concentrations of greenhouse gases produces a positive climate forcing or warming effect [EPA, Climate Change Indicators]. Therefore, mitigation of GHG concentrations is important to prevent long-term impacts on the environment. On April 4, 2016, California State University, Los Angeles signed the most comprehensive of Second Nature’s three Climate Leadership Commitments, the Climate Commitment. Following this commitment, California State University, Los Angeles, set the ambitious goal of operational carbon neutrality by the year 2040. To assist California State University, Los Angeles in moving effectively toward this goal, we developed an energy dashboard that can bring access, awareness, and education to campus about campus carbon footprint and promote energy-efficient behaviors. The developed energy dashboard is an interactive web application that works based on an energy model that is composed of various energy-consuming and GHG producing units such as Heating, Ventilation and Air Conditioning (HVAC), Heated Potable Water (HPW), Electricity, and Campus-Related Commutes. This energy dashboard enables individuals to analyze the campus’s energy consumption and carbon footprint. Our research showed that campus-related commute was the first largest contributor to Cal State LA’s carbon footprint in 2018 and accounted for 71.5% of carbon emissions. Electricity and heated potable water accounted for 20%, and 8.5% of the total campus carbon emissions, respectively. * Our developed energy dashboard is currently accessible at the following link [Khodayari, Arezoo et. al.]: https://cysun.org/espc-researchlab/EnergyDashboard