102 research outputs found
The Influence of UVA and Visible Radiation on Acute Damage by Short-Wave UVR (λ < 320 nm)
The influence of UVA and visible radiation on the acute damage by short-wave ultraviolet radiation (UVR) (λ < 320 nm) was investigated in human volunteers, using delayed erythema and sunburn cell production as markers of injury. It was found that subsequent exposure to UVA + visible radiation produced a significant reduction of the threshold erythema dose by short-wave UVR, in a dose-dependent manner. Subsequent exposures to varying doses of UVA + visible radiation, as well as to visible light alone failed to influence sunburn cell production. It is concluded that there is a positive interaction between short-wave UVR and UVA in the induction of delayed erythema, but this may not apply to epidermal cell injury. Photorecovery was not observed
Identification of Systemic Phototoxic Drugs by Human Intradermal Assay
An improved method is presented for the detection of systemically administered photosensitizing drugs in humans. Test agents were injected intradermally in physiologic saline and then exposed to broad spectrum radiation from a Xenon solar simulator. Several clinically recognized photosensitizers were identified by this technique. The activating spectrum depended on the test drug. Sulfonamides and vinblastin were activated by sunburning erythemic radiation (UV-B), while tetracyclines, nalidixic acid and phenothiazines by near UV (UV-A), and chlorothiazide by both. It is suggested that intradermal phototesting offers a means of verifying the phototoxic potential of agents suspected clinically of provoking a photosensitivity eruption
Consequences for sun protection factors when solar simulator spectra deviate from the spectrum of the sun
Effect of Varying Dose of UV Radiation on Mammalian Skin: Simulation of Decreasing Stratospheric Ozone
The Influence of UVA and Visible Radiation on Acute Damage by Short-Wave UVR (λ < 320 nm)
Long-wave UVA offers partial protection against UVB-induced immune suppression in human skin
In vivo persistent pigment darkening method: a demonstration of the reproducibility of the UVA protection factors results at several testing laboratories
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