112 research outputs found
Decarboxylating free fatty acids into fuels using subcritical water
Biofuel producers are looking into new avenues for utilization of their byproducts to improve their profitability in an environmentally friendly way. The biodiesel market has become saturated with very low margins and blenders cannot utilize this product in the winter. In order to address this problem, attention has now shifted towards a range of other possible products that can be made from non-food grade byproduct oils, including green diesel (a diesel having the same analytical signature as petroleum diesel), jet fuels, and other high value products. The major goal of this work was to investigate the hydrothermal conversion of bio-oil to fuel grade hydrocarbons as green diesel. Oleic acid was selected as a model compound of bio-oil to understand the reaction chemistry. Hydrothermal reactions were carried out in a CSTR (batch mode) from 300 to 450oC and reaction time was varied from 10 minutes to 6 hours. GC-FID and GC-TCD were used to analyze the liquid and gas samples, respectively. GC-TCD results showed that decarboxylation and decarbonylation of oleic acid was occurred whereas decarboxylation is the dominating chemical reaction. FTIR results also confirmed the decarboxylation of oleic acid and density measurement of the liquid proves that it falls between the diesel and kerosene.
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PyDaddy: A Python package for discovering stochastic dynamical equations from timeseries data
Most real-world ecological dynamics, ranging from ecosystem dynamics to
collective animal movement, are inherently stochastic in nature. Stochastic
differential equations (SDEs) are a popular modelling framework to model
dynamics with intrinsic randomness. Here, we focus on the inverse question: If
one has empirically measured time-series data from some system of interest, is
it possible to discover the SDE model that best describes the data. Here, we
present PyDaddy (PYthon library for DAta Driven DYnamics), a toolbox to
construct and analyze interpretable SDE models based on time-series data. We
combine traditional approaches for data-driven SDE reconstruction with an
equation learning approach, to derive symbolic equations governing the
stochastic dynamics. The toolkit is presented as an open-source Python library,
and consists of tools to construct and analyze SDEs. Functionality is included
for visual examination of the stochastic structure of the data, guided
extraction of the functional form of the SDE, and diagnosis and debugging of
the underlying assumptions and the extracted model. Using simulated time-series
datasets, exhibiting a wide range of dynamics, we show that PyDaddy is able to
correctly identify underlying SDE models. We demonstrate the applicability of
the toolkit to real-world data using a previously published movement data of a
fish school. Starting from the time-series of the observed polarization of the
school, pyDaddy readily discovers the SDE model governing the dynamics of group
polarization. The model recovered by PyDaddy is consistent with the previous
study. In summary, stochastic and noise-induced effects are central to the
dynamics of many biological systems. In this context, we present an easy-to-use
package to reconstruct SDEs from timeseries data
Noise-induced schooling of fish
We report on the dynamics of collective alignment in groups of the cichlid
fish, Etroplus suratensis. Focusing on small-to-intermediate sized groups
(), we demonstrate that schooling (highly polarised and coherent
motion) is noise-induced, arising from the intrinsic stochasticity associated
with finite numbers of interacting fish. The fewer the fish, the greater the
(multiplicative) noise and therefore the likelihood of alignment. Such
empirical evidence is rare, and tightly constrains the possible underlying
interactions between fish: computer simulations indicate that E. suratensis
align with each other one at a time, which is at odds with the canonical
mechanism of collective alignment, local direction-averaging. More broadly, our
results confirm that, rather than simply obscuring otherwise deterministic
dynamics, noise is fundamental to the characterisation of emergent collective
behaviours, suggesting a need to re-appraise aspects of both collective motion
and behavioural inference.Comment: Main manuscript: 8 pages (incl. refs), 4 figures. Supplementary: 11
pages, 5 figure
How honeybees respond to heat stress from the individual to colony level
A honey bee colony functions as an integrated collective, with individuals coordinating their behaviour to adapt and respond to unexpected disturbances. Nest homeostasis is critical for colony function; when ambient temperatures increase, individuals switch to thermoregulatory roles to cool the nest, such as fanning and water collection. While prior work has focused on bees engaged in specific behaviours, less is known about how responses are coordinated at the colony level, and how previous tasks predict behavioural changes during a heat stress. Using BeesBook automated tracking, we follow thousands of individuals during an experimentally induced heat stress, and analyse their behavioural changes from the individual to colony level. We show that heat stress causes an overall increase in activity levels and a spatial reorganization of bees away from the brood area. Using a generalized framework to analyse individual behaviour, we find that individuals differ in their response to heat stress, which depends on their prior behaviour and correlates with age. Examining the correlation of behavioural metrics over time suggests that heat stress perturbation does not have a long-lasting effect on an individual’s future behaviour. These results demonstrate how thousands of individuals within a colony change their behaviour to achieve a coordinated response to an environmental disturbance
Attack trees in Isabelle
In this paper, we present a proof theory for attack trees. Attack trees are a well established and useful model for the construction of attacks on systems since they allow a stepwise exploration of high level attacks in application scenarios. Using the expressiveness of Higher Order Logic in Isabelle, we succeed in developing a generic theory of attack trees with a state-based semantics based on Kripke structures and CTL. The resulting framework allows mechanically supported logic analysis of the meta-theory of the proof calculus of attack trees and at the same time the developed proof theory enables application to case studies. A central correctness and completeness result proved in Isabelle establishes a connection between the notion of attack tree validity and CTL. The application is illustrated on the example of a healthcare IoT system and GDPR compliance verification
A Multicenter Evaluation of Different Chemotherapy Regimens in Older Adults With Head and Neck Squamous Cell Carcinoma Undergoing Definitive Chemoradiation
PURPOSE: The number of older adults with head-and-neck squamous cell carcinoma (HNSCC) is increasing, and treatment of these patients is challenging. Although cisplatin-based chemotherapy concomitantly with radiotherapy is considered standard regimen for patients with locoregionally advanced HNSCC, there is substantial real-world heterogeneity regarding concomitant chemotherapy in older HNSCC patients.
METHODS: The XXX study is an international multicenter cohort study including older (≥65 years) HNSCC patients treated with definitive radiotherapy at 13 academic centers in the United States and Europe. Here, patients with concomitant chemoradiation were analyzed regarding overall survival (OS) and progression-free survival (PFS) using Kaplan-Meier analyses, while Fine-Gray competing risks regressions were performed regarding the incidence of locoregional failures (LRFs) and distant metastases (DMs).
RESULTS: Six hundred ninety-seven patients with a median age of 71 years were included in this analysis. Single-agent cisplatin was the most common chemotherapy regimen (n=310; 44%), followed by cisplatin plus 5-fluorouracil (n=137; 20%), carboplatin (n=73; 10%), and mitomycin c plus 5-fluorouracil (n=64; 9%). Carboplatin-based regimens were associated with diminished PFS (HR=1.39 [1.03-1.89], p.05). Median cumulative dose of cisplatin was 180 mg/m2 (IQR, 120-200 mg/m2). Cumulative cisplatin doses ≥200 mg/m2 were associated with increased OS (HR=0.71 [0.53-0.95], p=.02), PFS (HR=0.66 [0.51-0.87], p=.003), and lower incidence of LRFs (SHR=0.50 [0.31-0.80], p=.004). Higher cumulative cisplatin doses remained an independent prognostic variable in the multivariate regression analysis for OS (HR=0.996 [0.993-0.999], p=.009).
CONCLUSIONS: Single-agent cisplatin can be considered as the standard chemotherapy regimen for older HNSCC patients who can tolerate cisplatin. Cumulative cisplatin doses are prognostically relevant also in older HNSCC patients
Lifestyle factors and primary glioma and meningioma tumours in the Million Women Study cohort
Previous studies have reported inconsistent results on the effect of anthropometric and lifestyle factors on the risk of developing glioma or meningioma tumours. A prospective cohort of 1.3 million middle-aged women was used to examine these relationships. During 7.7 million women-years of follow-up, a total of 1563 women were diagnosed with a primary incident central nervous system tumour: 646 tumours were classified as glioma and 390 as meningioma. Our results show that height is related to the incidence of all central nervous system tumours with a risk of about 20% per 10 cm increase in height (relative risk=1.19, 95% CI=1.10–1.30 per 10 cm increase in height, P<0.001): the risks did not differ significantly between specified glioma and meningioma. Body mass index (BMI) was also related to central nervous system tumour incidence, with a risk of about 20% per 10 kg m−2 increase in BMI (relative risk=1.17, 95% CI=1.03–1.34 per 10 kg m−2 increase in BMI, P=0.02). Smoking status, alcohol intake, socioeconomic level, parity, age at first birth, and oral contraceptive use were not associated with the risk of glioma or meningioma tumours. In conclusion, for women in the United Kingdom, the incidence of glioma or meningioma tumours increases with increasing height and increasing BMI
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