2,208 research outputs found
Reforming the cancer drug fund focus on drugs that might be shown to be cost effective
The Cancer Drug Fund was originally conceived as a temporary measure, until value based pricing for drugs was introduced, to give NHS cancer patients access to drugs not approved by NICE. Spending on these drugs rose from less than the £50m (€63m; $79m) budgeted for the first year in 2010-11 to well over £200m
in 2013-14, and the budget for the scheme—now extended for a further two years—will reach £280m by 2016.1 The recent changes to the fund recognise the impossibility, within any sensible budget limit, of providing all the new cancer drugs that offer possible benefit to patients. More radical changes are
needed to the working of the fund, given the failure to introduce value based pricing, so that it deals with the underlying problem of inadequate information on the effectiveness and cost effectiveness of new cancer drugs when used in the NHS
Tests of Bayesian Model Selection Techniques for Gravitational Wave Astronomy
The analysis of gravitational wave data involves many model selection
problems. The most important example is the detection problem of selecting
between the data being consistent with instrument noise alone, or instrument
noise and a gravitational wave signal. The analysis of data from ground based
gravitational wave detectors is mostly conducted using classical statistics,
and methods such as the Neyman-Pearson criteria are used for model selection.
Future space based detectors, such as the \emph{Laser Interferometer Space
Antenna} (LISA), are expected to produced rich data streams containing the
signals from many millions of sources. Determining the number of sources that
are resolvable, and the most appropriate description of each source poses a
challenging model selection problem that may best be addressed in a Bayesian
framework. An important class of LISA sources are the millions of low-mass
binary systems within our own galaxy, tens of thousands of which will be
detectable. Not only are the number of sources unknown, but so are the number
of parameters required to model the waveforms. For example, a significant
subset of the resolvable galactic binaries will exhibit orbital frequency
evolution, while a smaller number will have measurable eccentricity. In the
Bayesian approach to model selection one needs to compute the Bayes factor
between competing models. Here we explore various methods for computing Bayes
factors in the context of determining which galactic binaries have measurable
frequency evolution. The methods explored include a Reverse Jump Markov Chain
Monte Carlo (RJMCMC) algorithm, Savage-Dickie density ratios, the Schwarz-Bayes
Information Criterion (BIC), and the Laplace approximation to the model
evidence. We find good agreement between all of the approaches.Comment: 11 pages, 6 figure
Models and applications for measuring the impact of health research: Update of a systematic review for the health technology assessment programme
This report reviews approaches and tools for measuring the impact of research programmes, building on, and extending, a 2007 review. Objectives: (1) To identify the range of theoretical models and empirical approaches for measuring the impact of health research programmes; (2) to develop a taxonomy of models and approaches; (3) to summarise the evidence on the application and use of these models; and (4) to evaluate the different options for the Health Technology Assessment (HTA) programme. Data sources: We searched databases including Ovid MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health Literature and The Cochrane Library from January 2005 to August 2014. Review methods: This narrative systematic literature review comprised an update, extension and analysis/discussion. We systematically searched eight databases, supplemented by personal knowledge, in August 2014 through to March 2015. Results: The literature on impact assessment has much expanded. The Payback Framework, with adaptations, remains the most widely used approach. It draws on different philosophical traditions, enhancing an underlying logic model with an interpretative case study element and attention to context. Besides the logic model, other ideal type approaches included constructionist, realist, critical and performative. Most models in practice drew pragmatically on elements of several ideal types. Monetisation of impact, an increasingly popular approach, shows a high return from research but relies heavily on assumptions about the extent to which health gains depend on research. Despite usually requiring systematic reviews before funding trials, the HTA programme does not routinely examine the impact of those trials on subsequent systematic reviews. The York/Patient-Centered Outcomes Research Institute and the Grading of Recommendations Assessment, Development and Evaluation toolkits provide ways of assessing such impact, but need to be evaluated. The literature, as reviewed here, provides very few instances of a randomised trial playing a major role in stopping the use of a new technology. The few trials funded by the HTA programme that may have played such a role were outliers. Discussion: The findings of this review support the continued use of the Payback Framework by the HTA programme. Changes in the structure of the NHS, the development of NHS England and changes in the National Institute for Health and Care Excellence’s remit pose new challenges for identifying and meeting current and future research needs. Future assessments of the impact of the HTA programme will have to take account of wider changes, especially as the Research Excellence Framework (REF), which assesses the quality of universities’ research, seems likely to continue to rely on case studies to measure impact. The HTA programme should consider how the format and selection of case studies might be improved to aid more systematic assessment. The selection of case studies, such as in the REF, but also more generally, tends to be biased towards high-impact rather than low-impact stories. Experience for other industries indicate that much can be learnt from the latter. The adoption of researchfish® (researchfish Ltd, Cambridge, UK) by most major UK research funders has implications for future assessments of impact. Although the routine capture of indexed research publications has merit, the degree to which researchfish will succeed in collecting other, non-indexed outputs and activities remains to be established. Limitations: There were limitations in how far we could address challenges that faced us as we extended the focus beyond that of the 2007 review, and well beyond a narrow focus just on the HTA programme. Conclusions: Research funders can benefit from continuing to monitor and evaluate the impacts of the studies they fund. They should also review the contribution of case studies and expand work on linking trials to meta-analyses and to guidelines. Funding: The National Institute for Health Research HTA programme
A Bayesian Approach to the Detection Problem in Gravitational Wave Astronomy
The analysis of data from gravitational wave detectors can be divided into
three phases: search, characterization, and evaluation. The evaluation of the
detection - determining whether a candidate event is astrophysical in origin or
some artifact created by instrument noise - is a crucial step in the analysis.
The on-going analyses of data from ground based detectors employ a frequentist
approach to the detection problem. A detection statistic is chosen, for which
background levels and detection efficiencies are estimated from Monte Carlo
studies. This approach frames the detection problem in terms of an infinite
collection of trials, with the actual measurement corresponding to some
realization of this hypothetical set. Here we explore an alternative, Bayesian
approach to the detection problem, that considers prior information and the
actual data in hand. Our particular focus is on the computational techniques
used to implement the Bayesian analysis. We find that the Parallel Tempered
Markov Chain Monte Carlo (PTMCMC) algorithm is able to address all three phases
of the anaylsis in a coherent framework. The signals are found by locating the
posterior modes, the model parameters are characterized by mapping out the
joint posterior distribution, and finally, the model evidence is computed by
thermodynamic integration. As a demonstration, we consider the detection
problem of selecting between models describing the data as instrument noise, or
instrument noise plus the signal from a single compact galactic binary. The
evidence ratios, or Bayes factors, computed by the PTMCMC algorithm are found
to be in close agreement with those computed using a Reversible Jump Markov
Chain Monte Carlo algorithm.Comment: 19 pages, 12 figures, revised to address referee's comment
The myogenic response in uremic hypertension
The myogenic response in uremic hypertension.BackgroundThe constriction of resistance arteries in response to an increase in transmural pressure, the myogenic response, is thought to be an important determinant of peripheral vascular resistance and therefore of arterial blood pressure. Since raised peripheral resistance is known to occur in uremic hypertension, abnormal myogenic constriction might be responsible. We sought to assess the myogenic response of resistance arteries from the subtotal nephrectomy rat model of uremic hypertension.MethodsUremic Wistar-Kyoto (WKYU) rats, and sham-operated normotensive (WKYC) and spontaneously hypertensive (SHRC) controls were studied in parallel. Skeletal muscle arteries were mounted on a pressure myograph and allowed to develop myogenic constriction. The active internal diameter was measured at increasing lumen pressures from 20 to 200 mm Hg. Vascular smooth muscle then was relaxed in a calcium free solution containing nitroprusside, and the passive internal diameter measured at the same pressure steps. The ratio of active to passive diameter at any given pressure was used to assess the myogenic response.ResultsMyogenic constriction was not increased in either WKYU or SHRC compared to WKYC at pressures up to 180 mm Hg.ConclusionsIncreased myogenic tone is not the cause of uremic hypertension
Recommended from our members
The impact generated by public and charity-funded research in the UK: A systematic literature review
Objective: To identify, synthesize and critically assess the empirical evidence of the impact generated by public and charity funded health research in the United Kingdom.
Methods: We conducted a systematic literature review of the empirical evidence published in English in peer-reviewed journals between 2006 and 2017. Studies meeting the inclusion criteria were selected and their findings were analysed using the Payback Framework into five main categories: knowledge, benefits to future research and research use, benefits from informing policy and product development, health and health sector benefits and broader economic benefits. We assessed the studies for risk of selection, reporting and funding bias.
Results: Thirteen studies met the inclusion criteria. The majority of the studies (10 out of 13) assessed impact at multiple domains including the main 5 key themes of the Payback Framework. All of them showed a positive impact of funded research on outcomes. Of those studies, one presented low risk of bias (8%), 6 studies were classified as presenting moderate risk of bias (46%) and 6 studies presented high risk of bias (46%).
Conclusions: Empirical evidence on the impact of public and charity funded research is still limited and subject to funding and selection bias. More work is needed to establish the causal effects of funded research on academic outcomes, policy, practice and the broader economy
The SWAP EUV Imaging Telescope Part I: Instrument Overview and Pre-Flight Testing
The Sun Watcher with Active Pixels and Image Processing (SWAP) is an EUV
solar telescope on board ESA's Project for Onboard Autonomy 2 (PROBA2) mission
launched on 2 November 2009. SWAP has a spectral bandpass centered on 17.4 nm
and provides images of the low solar corona over a 54x54 arcmin field-of-view
with 3.2 arcsec pixels and an imaging cadence of about two minutes. SWAP is
designed to monitor all space-weather-relevant events and features in the low
solar corona. Given the limited resources of the PROBA2 microsatellite, the
SWAP telescope is designed with various innovative technologies, including an
off-axis optical design and a CMOS-APS detector. This article provides
reference documentation for users of the SWAP image data.Comment: 26 pages, 9 figures, 1 movi
- …