Advanced Computational Methods in Bio-Mechanics

A novel partnership between surgeons and machines, made possible by advances in computing and engineering technology, could overcome many of the limitations of traditional surgery. By extending surgeons’ ability to plan and carry out surgical interventions more accurately and with fewer traumas, computer-integrated surgery (CIS) systems could help to improve clinical outcomes and the efficiency of healthcare delivery. CIS systems could have a similar impact on surgery to that long since realised in computer-integrated manufacturing. Mathematical modelling and computer simulation have proved tremendously successful in engineering.Computational mechanics has enabled technological developments in virtually every area of our lives. One of the greatest challenges for mechanists is to extend the success of computational mechanics to fields outside traditional engineering, in particular to biology, the biomedical sciences, and medicine. Biomechanics has significant potential for applications in orthopaedic industry, and the performance arts since skills needed for these activities are visibly related to the human musculoskeletal and nervous systems.Although biomechanics is widely used nowadays in the orthopaedic industry to design orthopaedic implants for human joints, dental parts, external fixations and other medical purposes, numerous researches funded by billions of dollars are still running to build a new future for sports and human healthcare in what is called biomechanics era

The Biomechanical Effect of Different Denture Base Materials on the Articular Disc in Complete Denture Wearers: A Finite Element Analysis

AIM: The objective of the present study was to evaluate the effect of different denture base materials on the stress distribution in TMJ articular disc (AD) in complete denture wearers.MATERIAL AND METHODS: Two three dimensional Finite Element (FEA) models of an individual temporomandibular joint (TMJ) were built on the basis CT scan. The FEA model consisted of four parts: the condyle, the articular disc, the denture base, and the articular eminence skull. Acrylic resin and chrome-cobalt denture base materials were studied. Static loading of 300N was vertically applied to the central fossa of the mandibular second premolar. Stress and strain were calculated to characterize the stress/strain patterns in the disc.RESULTS: The maximum tensile stresses were observed in the anterior and posterior bands of (AD) on load application with the two denture base materials. The superior boundaries of the glenoid fossa showed lower stress than those on the inferior boundaries facing the condyle.CONCLUSIONS: Within the limitations of the present study it may be concluded that: The denture base material may a have an effect in stress-strain pattern in TMJ articular disc. The stiffer denture base material, the better the distribution of the load to the underling mandibular supporting structures & reducing stresses induced in the articular disc

Recent Advances in Material and Geometrical Modelling in Dental Applications

This article touched, in brief, the recent advances in dental materials and geometric modelling in dental applications. Most common categories of dental materials as metallic alloys, composites, ceramics and nanomaterials were briefly demonstrated. Nanotechnology improved the quality of dental biomaterials. This new technology improves many existing materials properties, also, to introduce new materials with superior properties that covered a wide range of applications in dentistry. Geometric modelling was discussed as a concept and examples within this article. The geometric modelling with engineering Computer-Aided-Design (CAD) system(s) is highly satisfactory for further analysis or Computer-Aided-Manufacturing (CAM) processes. The geometric modelling extracted from Computed-Tomography (CT) images (or its similar techniques) for the sake of CAM also reached a sufficient level of accuracy, while, obtaining efficient solid modelling without huge efforts on body surfaces, faces, and gaps healing is still doubtable. This article is merely a compilation of knowledge learned from lectures, workshops, books, and journal articles, articles from the internet, dental forum, and scientific groups' discussions

Preliminary design and analysis of a photovoltaic-powered direct air capture system for a residential building

To promote the adoption of Direct Air Capture (DAC) systems, this paper proposes and tests a photovoltaic-powered DAC system in a generic residential building located in Qatar. The proposed DAC system can efficiently reduce CO2 concentration in a living space, thus providing an incentive to individuals to adopt it. The ventilation performance of the building is determined using Computational Fluid Dynamics (CFD) simulations, undertaken with ANSYS-CFD. The CFD model was validated using microclimate-air quality dataloggers. The simulated velocity was 1.4 m/s and the measured velocity was 1.35 m/s, which corresponds to a 3.5% error. The system decarbonizes air supplied to the building by natural ventilation or ventilation according to the ASHRAE standards. Furthermore, the performance of the photovoltaic system is analyzed using the ENERGYPLUS package of the Design Builder software. We assume that 75% of CO2 is captured. In addition, a preliminary characterization of the overall system’s performance is determined. It is determined that the amount of CO2 captured by the system is 0.112 tones/year per square meter of solar panel area. A solar panel area of 19 m2 is required to decarbonize the building with natural ventilation, and 27 m2 is required in the case of ventilation according to the ASHRAE standard

Preliminary design and analysis of a photovoltaic-powered direct air capture system for a residential building

To promote the adoption of Direct Air Capture (DAC) systems, this paper proposes and tests a photovoltaic-powered DAC system in a generic residential building located in Qatar. The proposed DAC system can efficiently reduce CO2 concentration in a living space, thus providing an incentive to individuals to adopt it. The ventilation performance of the building is determined using Computational Fluid Dynamics (CFD) simulations, undertaken with ANSYS-CFD. The CFD model was validated using microclimate-air quality dataloggers. The simulated velocity was 1.4 m/s and the measured velocity was 1.35 m/s, which corresponds to a 3.5% error. The system decarbonizes air supplied to the building by natural ventilation or ventilation according to the ASHRAE standards. Furthermore, the performance of the photovoltaic system is analyzed using the ENERGYPLUS package of the Design Builder software. We assume that 75% of CO2 is captured. In addition, a preliminary characterization of the overall system’s performance is determined. It is determined that the amount of CO2 captured by the system is 0.112 tones/year per square meter of solar panel area. A solar panel area of 19 m2 is required to decarbonize the building with natural ventilation, and 27 m2 is required in the case of ventilation according to the ASHRAE standard

Utilization of prickly pear waste for baker's yeast production

The feasibility of baker's yeast production using fruits and peels of Opuntia ficus indica (OFI) as carbohydrate feedstock was investigated. Two response surface methodologies involving central composite face centered design (CCFD) were successfully applied. The effects of four independent variables on baker's yeast production from OFI fruit juice was evaluated using the first CCFD. The best results were obtained with 24 H of inoculum age, 30 degrees C temperature, 200 rpm of agitation, and 10% inoculum size. At the maximum point, the biomass concentration reached 9.29 g/L. A second CCFD was performed to optimize the sugar extraction from OFI fruit peels. The potential of these latter as a fermentation substrate was determined. From the experimental results, the OFI fruit peel is an appropriate carbon source for the production of baker's yeast. The maximum biomass concentration was 12.51 g/L. Different nitrogen supplements were added to promote the yields of baker's yeast. Corn steep liquor was found to be the best alternative nutrient source of casein hydrolysate and yeast extract for baker's yeast production.info:eu-repo/semantics/publishedVersio

3D FEA study on: Implant Threading Role on Selection of Implant and Crown Materials

AIM: This study deeply investigates the effect of dental implant threading and material selection on the mandibular bone under two different crown materials (Translucent Zirconia and Porcelain fused to metal). METHODS: Two different designs of single piece dental implants were supporting dummy crown above simplified bone geometry in two finite element models. Models components were created by general-purpose CAD/CAM engineering package and then assembled inside ANSYS before meshing and assigning materials. Compressive loading of 100 N and 45º oblique loading of 50 N were tested. RESULTS: Twenty-four case studies were analysed, and their results were compared. Micro thread reduces implant maximum Von Mises stress by about 50 to 70% than regular thread one. Oblique loading of 50 N will produce 4 to 5 times more maximum Von Mises values on implant body than 100 N vertical loading. Zero or negligible effect on the cortical bone was recorded when exchanging the tested crown material. Although titanium implant can also reduce cortical bone, Von Mises stress by 50 to 100% in comparison to reinforced PEKK (poly ether-ketone-ketone) or PEEK (poly-ether-ether-ketone). CONCLUSIONS: Reinforced PEKK and PEEK implants can represent a good alternative to titanium implants. Zirconia crown distributes the applied load better than Porcelain fused to a metal one. Regardless of the implant material, an implant with the micro thread has superior behaviour in comparison to a regular one. Zirconia crown above titanium implant with the micro thread may represent the best option for patient bone

Age, Disease Severity and Ethnicity Influence Humoral Responses in a Multi-Ethnic COVID-19 Cohort

The COVID-19 pandemic has affected all individuals across the globe in some way. Despite large numbers of reported seroprevalence studies, there remains a limited understanding of how the magnitude and epitope utilization of the humoral immune response to SARS-CoV-2 viral anti-gens varies within populations following natural infection. Here, we designed a quantitative, multi-epitope protein microarray comprising various nucleocapsid protein structural motifs, including two structural domains and three intrinsically disordered regions. Quantitative data from the microarray provided complete differentiation between cases and pre-pandemic controls (100% sensitivity and specificity) in a case-control cohort (n = 100). We then assessed the influence of disease severity, age, and ethnicity on the strength and breadth of the humoral response in a multi-ethnic cohort (n = 138). As expected, patients with severe disease showed significantly higher antibody titers and interestingly also had significantly broader epitope coverage. A significant increase in antibody titer and epitope coverage was observed with increasing age, in both mild and severe disease, which is promising for vaccine efficacy in older individuals. Additionally, we observed significant differences in the breadth and strength of the humoral immune response in relation to ethnicity, which may reflect differences in genetic and lifestyle factors. Furthermore, our data enabled localization of the immuno-dominant epitope to the C-terminal structural domain of the viral nucleocapsid protein in two independent cohorts. Overall, we have designed, validated, and tested an advanced serological assay that enables accurate quantitation of the humoral response post natural infection and that has revealed unexpected differences in the magnitude and epitope utilization within a population

Democratization and the Diffusion of Shari'a Law: Comparative Insights from Indonesia

The democratization of politics has been accompanied by a rise of Islamic laws in many Muslim-majority countries. Despite a growing interest in the phenomenon, the Islamization of politics in democratizing Muslim-majority countries is rarely understood as a process that unfolds across space and time. Based on an original dataset established during years of field research in Indonesia, this article analyzes the spread of shari’a regulations across the world’s largest Muslim-majority democracy since 1998. The article shows that shari’a regulations in Indonesia diffused unevenly across space and time. Explanations put forward in the literature on the diffusion of morality policies in other countries such as geographic proximity, institutions, intergovernmental relations and economic conditions did not explain the patterns in the diffusion of shari’a regulations in Indonesia well. Instead, shari’a regulations in Indonesia were most likely to spread across jurisdictions where local Islamist groups situated outside the party system had an established presence. In short, the Islamization of politics was highly contingent on local conditions. Future research will need to pay more attention to local Islamist activists and networks situated outside formal politics as potential causes for the diffusion of shari’a law in democratizing Muslim-majority countries