Longevity, Growth and Intergenerational Equity - The Deterministic Case

Challenges raised by ageing (increasing longevity) have prompted policy debates featuring policy proposals justified by reference to some notion of intergenerational equity. However, very different policies ranging from pre-savings to indexation of retirement ages have been justified in this way. We develop an overlapping generations model in continuous time which encompasses different generations with different mortality rates and thus longevity. Allowing for trend increases in both longevity and productivity, we address the issue of intergenerational equity under a utilitarian criterion when future generations are better off in terms of both material and non-material well being. Increases in productivity and longevity are shown to have very different implications for intergenerational distribution.

NAC blocks Cystatin C amyloid complex aggregation in a cell system and in skin of HCCAA patients.

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked DownloadHereditary cystatin C amyloid angiopathy is a dominantly inherited disease caused by a leucine to glutamine variant of human cystatin C (hCC). L68Q-hCC forms amyloid deposits in brain arteries associated with micro-infarcts, leading ultimately to paralysis, dementia and death in young adults. To evaluate the ability of molecules to interfere with aggregation of hCC while informing about cellular toxicity, we generated cells that produce and secrete WT and L68Q-hCC and have detected high-molecular weight complexes formed from the mutant protein. Incubations of either lysate or supernatant containing L68Q-hCC with reducing agents glutathione or N-acetyl-cysteine (NAC) breaks oligomers into monomers. Six L68Q-hCC carriers taking NAC had skin biopsies obtained to determine if hCC deposits were reduced following NAC treatment. Remarkably, ~50-90% reduction of L68Q-hCC staining was observed in five of the treated carriers suggesting that L68Q-hCC is a clinical target for reducing agents.Artic Therapeutics LLC Autonomous Community of Madrid (CAM). Spai

Longevity, Growth and Intergenerational Equity - The Deterministic Case

Challenges raised by ageing (increasing longevity) have prompted policy debates featuring policy proposals justified by reference to some notion of intergenerational equity. However, very different policies ranging from pre-savings to indexation of retirement ages have been justified in this way. We develop an overlapping generations model in continuous time which encompasses different generations with different mortality rates and thus longevity. Allowing for both trend increases in longevity and productivity, we address the issue of intergenerational equity under a utilitarian criterion when future generations are better off in terms of both material and non-material well being. Increases in productivity and longevity are shown to have very different implications for intergenerational distribution.OLG models, demographics, longevity, taxes, transfers, retirement age, dependency ratio, healthy ageing, decentralization

Geothermal potential of small sub-volcanic intrusions in a typical Icelandic caldera setting

Geothermal exploration targets large magmatic intrusions as heat sources because of their size, longevity, and amount of stored energy, but as shallow volcanic plumbing systems comprise numerous smaller intrusions, their geothermal potential warrants consideration. Here, we evaluate the geothermal impact of dykes and sills on caldera-infill rocks. We present geological data and geothermometry on intrusions in the eroded Breiðuvík caldera in Northeast Iceland, which serves as an analogue to the active, and geothermally exploited, Krafla volcano. These data inform 2D finite element models of dyke and sill intrusions that consider heat transfer in porous media. Our results indicate that small intrusions create considerable thermal anomalies in their immediate vicinity. These anomalies are larger-magnitude and longer-lasting for individual thick sills and dykes, but networks of smaller sills and dykes emplaced close in time and space can create more widespread thermal anomalies that may be viable economic targets for decades after their emplacement

Thermal impact of dykes on ignimbrite and implications for fluid flow compartmentalisation in calderas

Ignimbrites within calderas host intrusions with hazardous and/or economically significant hydrothermal systems. The Hvítserkur ignimbrite at Breiðuvík caldera, north-eastern Iceland, is intruded by basaltic dykes. Our data show that the ignimbrite immediately adjacent to the dyke is hard, dark-coloured, recrystallised quartz, plagioclase, and alkali feldspar with a low permeability and porosity and frequent macrofractures. At 1-2 m from the dyke, the ignimbrite is hard, dominantly glassy with pervasive perlitic microfractures, has high permeability, but low porosity and frequent macrofractures. A narrow zone of pervasive unlithified clay exists 2 m from the dyke. Beyond this, the ignimbrite is soft and zeolite-rich, has low permeability, high porosity and fewer macrofractures. The dyke intrusion promoted a narrow zone of welding, fracturing and perlitisation in the ignimbrite resulting in high permeability and focussed alteration. Our study shows how intrusions and their thermal aureoles create vertical pathways for, and horizontal barriers to, geothermal fluid flow