First record of the Neolicaphrium recens Frenguelli, 1921 (Mammalia, Litopterna) in the Pleistocene of Santiago del Estero Province, Argentina

The first record of the Neolicaphrium recens Frenguelli, 1921 (Mammalia, Litopterna) from Pleistocene deposits of the Río Dulce, Rio Hondo Department, Santiago del Estero Province, Argentina, is reported. The morphology and morphometry observed in the specimen MPAT073 is coincident with the diagnostic characteristics of that species. This finding represents the northernmost and westernmost record of the species, and thus extends its geographical distribution. Geological data suggest that the material comes from a still unnamed Pleistocene stratigraphic unit. © 2017, Universidade de Sao Paulo. All rights reserved.Se presenta el primer registro del proterotérido Neolicaphrium recens Frenguelli, 1921 (Mammalia, Litopterna) en sedimentos del Río Dulce, Departamento Río Hondo, provincia de Santiago del Estero, Argentina. Los rasgos morfológicos y morfométricos observados en el espécimen MPAT073 son coincidentes con los caracteres indicados como diagnósticos de esa especie. Este hallazgo representa el registro más septentrional y occidental reportado hasta el momento para esta especie, y extiende su rango de distribución geográfica conocida. Los datos geológicos disponibles sugieren que el material proviene de una unidad todavía innominada del Pleistoceno.Facultad de Ciencias Naturales y Muse

In vitro faecal fermentation of Tritordeum breads and its effect on the human gut health

Spontaneous fermentation of Tritordeum flour enhances the nutritional potential of this hybrid cereal. However, the effect of consumption of Tritordeum sourdough bread (SDB) on gut health remains to be elucidated. This study investigated the effect of in vitro digestion and faecal fermentation of SDB compared to that of traditional baker's yeast (BYB) Tritordeum bread. After 24-h anaerobic faecal fermentation, both SDB and BYB (1% w/v) induced an increase in the relative abundances of Bifidobacterium, Megasphaera, Mitsuokella, and Phascolarctobacterium genera compared to baseline, while concentrations of acetate and butyrate were significantly higher at 24 h for SDB compared to those for BYB. Integrity of intestinal epithelium, as assessed through in vitro trans-epithelial electrical resistance (TEER) assay, was slightly increased after incubation with SDB fermentation supernatants, but not after incubation with BYB fermentation supernatants. The SDB stimulated in vitro mucosal immune response by inducing early secretion of inflammatory cytokines, IL-6 and TNF-α, followed by downregulation of the inflammatory trigger through induction of anti-inflammatory IL-10 expression. Overall, our findings suggest that Tritordeum sourdough can modulate gut microbiota fermentation activity and positively impact the gut health

Use of water troughs by wild rabbits (Oryctolagus cuniculus) in a farmland area of north–west Spain

Uso de bebederos por parte del conejo de monte (Oryctolagus cuniculus) en un paisaje agrícola en el noroeste de EspañaEn la península Ibérica, los bebederos son una herramienta de gestión de hábitat muy frecuente para incrementar las densidades de especies de caza menor, aunque el comportamiento de ingestión de agua de las especies “diana” no se ha estudiado en profundidad, como es el caso del conejo de monte (Oryctolagus cuniculus). Estudiamos el uso de bebederos por parte de conejos de monte durante 228 períodos de una semana en tres períodos consecutivos (junio–octubre) de 2008, 2009 y 2010 en un paisaje agrícola de noroeste de España, utilizando cámaras de fototrampeo. Los conejos utilizaron el 43% de los bebederos y se observó un número significativamente mayor de conejos bebiendo en bebederos rodeados por cobertura vegetal en comparación con bebederos situados en campos abiertos sin dicha cobertura vegetal. La mayoría de los conejos que bebieron fueron fotografiados de julio a septiembre (98%), si bien la utilización de bebederos no se relacionó claramente con la climatología. Los conejos bebieron principalmente durante la mañana (52% de los conejos) no tanto durante la tarde y noche, y raramente durante el mediodía. Los conejos se fotografiaron junto con perdices rojas (Alectoris rufa) en el 6% de las fotografías. Estos hallazgos sugieren que los bebederos son útiles para el conejo y otras especies con necesidades hídricas similares y que debieran ser colocados cerca de zonas con cobertura vegetal arbustiva.Installation of water troughs is a common approach to increase densities of small game species in the Iberian peninsula but little is known about the watering patterns of target species, such as the wild rabbit (Oryctolagus cuniculus). Using camera trapping, we monitored the use of water troughs by wild rabbits over 228 weeks in three consecutive periods, from June to October in 2008, 2009 and 2010, on farmland in north–west Spain. Wild rabbits used 43% of the water troughs. A significantly higher number of rabbits were observed drinking at troughs surrounded by shrub cover than at those in open fields. Most drinking events were recorded from July to September (98%), though the use of water troughs was not clearly related to weather. Wild rabbits drank mainly during the morning (52% of rabbits), less so in the evening and at night, and rarely in the afternoon. Wild rabbits were photographed together with red–legged partridges (Alectoris rufa) in 6% of photographs. These findings suggest water troughs are useful for species such as wild rabbits and should be allocated close to shrub areas.Uso de bebederos por parte del conejo de monte (Oryctolagus cuniculus) en un paisaje agrícola en el noroeste de EspañaEn la península Ibérica, los bebederos son una herramienta de gestión de hábitat muy frecuente para incrementar las densidades de especies de caza menor, aunque el comportamiento de ingestión de agua de las especies “diana” no se ha estudiado en profundidad, como es el caso del conejo de monte (Oryctolagus cuniculus). Estudiamos el uso de bebederos por parte de conejos de monte durante 228 períodos de una semana en tres períodos consecutivos (junio–octubre) de 2008, 2009 y 2010 en un paisaje agrícola de noroeste de España, utilizando cámaras de fototrampeo. Los conejos utilizaron el 43% de los bebederos y se observó un número significativamente mayor de conejos bebiendo en bebederos rodeados por cobertura vegetal en comparación con bebederos situados en campos abiertos sin dicha cobertura vegetal. La mayoría de los conejos que bebieron fueron fotografiados de julio a septiembre (98%), si bien la utilización de bebederos no se relacionó claramente con la climatología. Los conejos bebieron principalmente durante la mañana (52% de los conejos) no tanto durante la tarde y noche, y raramente durante el mediodía. Los conejos se fotografiaron junto con perdices rojas (Alectoris rufa) en el 6% de las fotografías. Estos hallazgos sugieren que los bebederos son útiles para el conejo y otras especies con necesidades hídricas similares y que debieran ser colocados cerca de zonas con cobertura vegetal arbustiva

Pten alterations and their role in cancer management: Are we making headway on precision medicine?

Alterations in the tumor suppressor phosphatase and tensin homolog (PTEN) occur in a substantial proportion of solid tumors. These events drive tumorigenesis and tumor progression. Given its central role as a downregulator of the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway, PTEN is deeply involved in cell growth, proliferation, and survival. This gene is also implicated in the modulation of the DNA damage response and in tumor immune microenvironment modeling. Despite the actionability of PTEN alterations, their role as biomarkers remains controversial in clinical practice. To date, there is still a substantial lack of validated guidelines and/or recommendations for PTEN testing. Here, we provide an update on the current state of knowledge on biologic and genetic alterations of PTEN across the most frequent solid tumors, as well as on their actual and/or possible clinical applications. We focus on possible tailored schemes for cancer patients\u2019 clinical management, including risk assessment, diagnosis, prognostication, and treatment

Bariatric surgery and diabetes remission: Sleeve gastrectomy or mini-gastric bypass?

AIM: To investigate the weight loss and glycemic control status [blood glucose, hemoglobin A1c (HbA1c) and hypoglycaemic treatment]. METHODS: The primary risk factor for type 2 diabetes is obesity, and 90% of all patients with type 2 diabetes are overweight or obese. Although a remarkable effect of bariatric surgery is the profound and durable resolution of type 2 diabetes clinical manifestations, little is known about the difference among various weight loss surgical procedures on diabetes remission. Data from patients referred during a 3-year period (from January 2009 to December 2011) to the University of Naples "Federico II" diagnosed with obesity and diabetes were retrieved from a prospective database. The patients were split into two groups according to the surgical intervention performed [sleeve gastrectomy (SG) and mini-gastric bypass (MGB)]. Weight loss and glycemic control status (blood glucose, HbA1c and hypoglycaemic treatment) were evaluated. RESULTS: A total of 53 subjects who underwent sleeve gastrectomy or mini-gastric bypass for obesity and diabetes were screened for the inclusion in this study. Of these, 4 subjects were excluded because of surgical complications, 7 subjects were omitted because young surgeons conducted the operations and 11 subjects were removed because of the lack of follow-up. Thirty-one obese patients were recruited for this study. A total of 15 subjects underwent SG (48.4%), and 16 underwent MGB (51.6%). After adjusting for various clinical and demographic characteristics in a multivariate logistic regression analysis, high hemoglobin A1c was determined to be a negative predictor of diabetes remission at 12 mo (OR = 0.366, 95%CI: 0.152-0.884). Using the same regression model, MGB showed a clear trend toward higher diabetes remission rates relative to SG (OR = 3.780, 95%CI: 0.961-14.872). CONCLUSION: Although our results are encouraging regarding the effectiveness of mini-gastric bypass on diabetes remission, further studies are needed to provide definitive conclusions in selecting the ideal procedure for diabetes remission

Current-Driven Conformational Changes, Charging and Negative Differential Resistance in Molecular Wires

We introduce a theoretical approach based on scattering theory and total energy methods that treats transport non-linearities, conformational changes and charging effects in molecular wires in a unified way. We apply this approach to molecular wires consisting of chain molecules with different electronic and structural properties bonded to metal contacts. We show that non-linear transport in all of these systems can be understood in terms of a single physical mechanism and predict that negative differential resistance at high bias should be a generic property of such molecular wires.Comment: 9 pages, 4 figure