Efficiency diagnostic and advantages of procalcitonin and C-reactive protein in the early diagnosis of sepsis

The goal of our study is to assess the diagnostic profi tability of procalcitonin (PCT) in septic shock and another biomarker as C-reactive protein (CRP). Results: Fifty-four septic patients were assessed, 66% were males; mean age, 63 years. Eighty-eight percent was diagnosed as septic shock and 11% severe sepsis. Seventy-six percent were medical patients. Positive blood cultures in 42.5%. Sepsis origin: respiratory 46%, neurological 5%, digestive 37% and urinary 3%. Average SOFA score was 10.4. Conclusions: PCT and CRP have the same efficiency in early sepsis diagnosis. The PCT and CRP effi ciency diagnostic together is signifi cant but small. We suggest using both with the doubt of sepsis.Ye

Anemia profile in critical septic patients hospitalized in the ICU

This article is part of the supplement: 31st International Symposium on Intensive Care and Emergency MedicineThe aim was to describe the anemia profile of medical or surgical patients with severe sepsis or septic shock in the ICU, assessing severity scale, length of stay and mortality. The prevalence of microcytic anemia is more than one-half of our septic patients. There are iron metabolism disorders without significant differences between medical and surgical patients. Transferrin, a protein related to malnutrition, inflammatory response and organ dysfunction, is significantly lower in the most severe patients with higher organ dysfunction scores.Ye

Aplicación de las tecnologías de la información a la tecnologia ictiológica: el sitio web 'www.ictioterm.es'

Aplicació de les tecnologies de la informació a la terminologia ictiològica: el lloc web www.ictioterm.es. ICTIOTERM és una base de dades que conté informació de tipus terminològic, lingüístic i biològic sobre més de tres-centes espècies marines de peixos, mol·luscos, crustacis i altres invertebrats. En aquest article es descriuen amb detall els continguts del web www.ictioterm.es, així com la seva estructura d'emmagatzematge de la informació i les diverses opcions de cerca.Application of Information Technology to Ichthyology Terms: ww.ictioterm.es ICTIOTERM is a database containing terminological, linguistic and biological information on more than 300 marine species of fish, molluscs, crustaceans and other invertebrates. In this paper, we describe the contents of the web site www.ictioterm.es, as well as its information storage structure and search options.ICTIOTERM es una base de datos que contiene información de tipo terminológico, lingüístico y biológico sobre más de trescientas especies marinas de peces, moluscos, crustáceos y otros invertebrados. En el presente trabajo, se describen de manera pormenorizada los contenidos del web www.ictioterm.es, así como su estructura de almacenamiento de la información y sus diferentes opciones de búsqueda

Activated protein C, severe sepsis and 28-day mortality

Protein C (PC) de ciency is prevalent in severe sepsis, studies showing that more than 80% of patients with severe sepsis have a baseline PC level below the lower limit of normal [1,2]. The aim of the study was to relate the anticoagulation activity evaluated by PC, with clinical parameters and 28-day mortality.Ye

Antithrombotic Treatment After Coronary Intervention: Agreement and Controversy

Percutaneous revascularisation has evolved dramatically in the past few decades. The approach to the management of ischaemic heart disease has changed due to the development of new devices and techniques as well as the availability of new drugs and treatment strategies. Its use in combination with antiplatelet therapies has been essential to protect against stent thrombosis. The length of time this combination therapy is used has been modified in recent years and has been the subject of extensive research. The effect of prolonging the time it is taken or shortening it has been evaluated in different clinical conditions. In practice, the decisions regarding antithrombotic therapy after percutaneous coronary intervention are informed by the patient’s profile and the characteristics of the procedures performed. In this article, we review the use of antiplatelet/anticoagulant therapy after percutaneous coronary intervention focusing on trials and guidelines addressing variable durations for combination regimens and the alternatives

Relationship between Parenting Styles and Aggressiveness in Adolescents

Abstract Introduction. Physical and verbal aggressive behavior that children and adolescents sho

Molecular Segmentation of the Spinal Trigeminal Nucleus in the Adult Mouse Brain

© 2021. The authors. This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the Published version of a Published Work that appeared in final form in Frontiers in Neuroanatomy. To access the final edited and published work see https://doi.org/10.3389/fnana.2021.785840The trigeminal column is a hindbrain structure formed by second order sensory neurons that receive afferences from trigeminal primary (ganglionic) nerve fibers. Classical studies subdivide it into the principal sensory trigeminal nucleus located next to the pontine nerve root, and the spinal trigeminal nucleus which in turn consists of oral, interpolar and caudal subnuclei. On the other hand, according to the prosomeric model, this column would be subdivided into segmental units derived from respective rhombomeres. Experimental studies have mapped the principal sensory trigeminal nucleus to pontine rhombomeres (r) r2-r3 in the mouse. The spinal trigeminal nucleus emerges as a plurisegmental formation covering several rhombomeres (r4 to r11 in mice) across pontine, retropontine and medullary hindbrain regions. In the present work we reexamined the issue of rhombomeric vs. classical subdivisions of this column. To this end, we analyzed its subdivisions in an AZIN2-lacZ transgenic mouse, known as a reference model for hindbrain topography, together with transgenic reporter lines for trigeminal fibers. We screened as well for genes differentially expressed along the axial dimension of this structure in the adult and juvenile mouse brain. This analysis yielded genes from multiple functional families that display transverse domains fitting the mentioned rhombomeric map. The spinal trigeminal nucleus thus represents a plurisegmental structure with a series of distinct neuromeric units having unique combinatorial molecular profiles

Puntuaciones tradicionales y estimaciones TRI en tests de elección forzosa con un modelo de dominancia

Background: Forced-choice tests (FCTs) were proposed to minimize response biases associated with Likert format items. It remains unclear whether scores based on traditional methods for scoring FCTs are appropriate for between-subjects comparisons. Recently, Hontangas et al. (2015) explored the extent to which traditional scoring of FCTs relates to the true scores and IRT estimates. The authors found certain conditions under which traditional scores (TS) can be used with FCTs when the underlying IRT model was an unfolding model. In this study, we examine to what extent the results are preserved when the underlying process becomes a dominance model. Method: The independent variables analyzed in a simulation study are: forced-choice format, number of blocks, discrimination of items, polarity of items, variability of intra-block diffi culty, range of diffi culty, and correlation between dimensions. Results: A similar pattern of results was observed for both models; however, correlations between TS and true thetas are higher and the differences between TS and IRT estimates are less discrepant when a dominance model involved. Conclusions: A dominance model produces a linear relationship between TS and true scores, and the subjects with extreme thetas are better measuredAntecedentes: los tests de elección forzosa (TEFs) fueron propuestos para reducir los sesgos de respuesta de ítems tipo Likert. Se cuestiona que los métodos de puntuación tradicional (PT) empleados permitan hacer comparaciones entre-sujetos. Recientemente, Hontangas et al. (2015) exploraron cómo las PTs obtenidas con diferentes TEFs se relacionan con sus puntuaciones verdaderas y estimaciones TRI, mostrando las condiciones para ser utilizadas cuando el modelo subyacente es un modelo de unfolding. El objetivo del trabajo actual es comprobar si el patrón de resultados se mantiene con un modelo de dominancia. Método: las variables independientes del estudio de simulación fueron: formato de elección forzosa, número de bloques, discriminación de los ítems, polaridad de los ítems, variabilidad de la dificultad intrabloque, rango de difi cultad del test y correlación entre dimensiones. Resultados: un patrón similar de resultados fue obtenido en ambos modelos, pero en el modelo de dominancia las correlaciones entre PTs y puntuaciones verdaderas son más altas y las diferencias entre PTs y estimaciones TRI se reducen. Conclusiones: un modelo de dominancia produce una relación lineal entre PTs y puntuaciones verdaderas, y los sujetos con puntuaciones extremas son medidos mejorThe research has been funded by the Ministry of Economy and Competitivity of Spain, project PSI2012-3334

The cyanobacterial ribosomal-associated protein LrtA from Synechocystis sp. PCC 6803 is an oligomeric protein in solution with chameleonic sequence properties

The LrtA protein of Synechocystis sp. PCC 6803 intervenes in cyanobacterial post-stress survival and in stabilizing 70S ribosomal particles. It belongs to the hibernating promoting factor (HPF) family of proteins, involved in protein synthesis. In this work, we studied the conformational preferences and stability of isolated LrtA in solution. At physiological conditions, as shown by hydrodynamic techniques, LrtA was involved in a self-association equilibrium. As indicated by Nuclear Magnetic Resonance (NMR), circular dichroism (CD) and fluorescence, the protein acquired a folded, native-like conformation between pH 6.0 and 9.0. However, that conformation was not very stable, as suggested by thermal and chemical denaturations followed by CD and fluorescence. Theoretical studies of its highly-charged sequence suggest that LrtA had a Janus sequence, with a context-dependent fold. Our modelling and molecular dynamics (MD) simulations indicate that the protein adopted the same fold observed in other members of the HPF family ( - - - - - ) at its N-terminal region (residues 1–100), whereas the C terminus (residues 100–197) appeared disordered and collapsed, supporting the overall percentage of overall secondary structure obtained by CD deconvolution. Then, LrtA has a chameleonic sequence and it is the first member of the HPF family involved in a self-association equilibrium, when isolated in solution.Ministerio de Economía y Competitividad CTQ2015-64445-RMinisterio de Economía y Competitividad BIO2016-78020-RMinisterio de Economía y Competitividad FIS2014-52212-RMinisterio de Economía y Competitividad BIO2016-75634-PFundación Séneca 19353/PI/1