Integrated methods and scenario development for urban groundwater management and protection during tunnel road construction: a case study of urban hydrogeology in the city of Basel, Switzerland

In the northwestern area of Basel, Switzerland, a tunnel highway connects the French highway A35 (Mulhouse-Basel) with the Swiss A2 (Basel-Gotthard-Milano). The subsurface highway construction was associated with significant impacts on the urban groundwater system. Parts of this area were formerly contaminated by industrial wastes, and groundwater resources are extensively used by industry. During some construction phases, considerable groundwater drawdown was necessary, leading to major changes in the groundwater flow regime. Sufficient groundwater supply for industrial users and possible groundwater pollution due to interactions with contaminated areas had to be taken into account. A groundwater management system is presented, comprising extensive groundwater monitoring, high-resolution numerical groundwater modeling, and the development and evaluation of different scenarios. This integrated approach facilitated the evaluation of the sum of impacts, and their interaction in time and space with changing hydrological boundary conditions. For all project phases, changes of the groundwater system had to be evaluated in terms of the various goals and requirements. Although the results of this study are case-specific, the overall conceptual approach and methodologies applied may be directly transferred to other urban area

Is the CERN recommended SCADA useable for the ST division?

Supervisory Control and Data Acquisition (SCADA) systems are widely used at CERN and in industrial control environments. In order to limit the costs of purchase, maintenance and support, a recommendation for one SCADA system is in preparation by the SCADA working group. This SCADA system should be used for all CERN in-house developed applications as they exist today e.g. in the Technical Control Room (TCR). This presentation will show the actual environment for the control and monitoring of the technical infrastructure at CERN and the needs for the future LHC infrastructure monitoring. The presentation will cover the control activities of all ST groups represented in the ST Control System WG. A possible solution for the integration of the technical infrastructure data into a SCADA system and a solution for the data exchange with the accelerators and the experiments will be presented. This includes a short term planning for the evaluation period as well as the long-term strategy on how to implement the chosen solution

TCR remote monitoring for the LHC technical infrastructure

The remote monitoring of the LHC technical infrastructure will mainly be done in CERN’s Technical Control Room (TCR). The technical infrastrucure consists of specialised equipment from different groups and divisions, mainly cooling and ventilation and electrical equipment. The responsibility for the definition, operation and maintenance of the equipment is covered by the relevant equipment group. However the monitoring and alerting for action in case of equipment failure is initiated by the TCR and is based on alarms that are sent by the equipment. This implies the correct integration of the equipment and the establishment of rules to follow during the commissioning and start-up of the equipment in order to ensure proper operation. This paper shows the integration possibilities and the different tasks and steps to follow by the different parties for smooth equipment integration and avoiding organizational problems

CERN LHC Technical Infrastructure Monitoring (TIM)

The CERN Large Hadron Collider (LHC) will start to deliver particles to its experiments in the year 2005. However, all the primary services such as electricity, cooling, ventilation, safety systems and others such as vacuum and cryogenics will be commissioned gradually between 2001 and 2005. This technical infrastructure will be controlled using industrial control systems, which have either already been purchased from specialized companies or are currently being put together for tender. This paper discusses the overall architecture and interfaces that will be used by the CERN Technical Control Room (TCR) to monitor the technical services at CERN and those of the LHC and its experiments. The issue of coherently integrating existing and future control systems over a period of five years with constantly evolving technology is addressed. The paper also summarizes the functionality of all the tools needed by the control room such as alarm reporting, data logging systems, man machine interfaces and the console manager. Particular attention is paid to networking aspects, so that reliable and timely transmission of data can be assured. A pyramidal layered component architecture is compared with a complete SCADA solution

The first year of the ST Operation Committee: is there a future ?

The main objective of the ST Operation Committee (STOC) was to develop a proactive and homogeneous service of operation that satisfies the needs of the service users. Furthermore, the role of the Technical Control Room (TCR) should have been developed to a unique and competent entry point for ST operation by bringing the operation teams closer together on a daily basis. Have these objectives been achieved and to what extend? Is there a future for this committee and what could it look like? What are the implications of the first year of work on ST operation as a whole? This paper answers these questions and gives recommendations how to make best use of the STOC for the ST partners and ST, respectively

Digit Ratio Predicts Sense of Direction in Women

The relative length of the second-to-fourth digits (2D:4D) has been linked with prenatal androgen in humans. The 2D:4D is sexually dimorphic, with lower values in males than females, and appears to correlate with diverse measures of behavior. However, the relationship between digit ratio and cognition, and spatial cognition in particular, has produced mixed results. In the present study, we hypothesized that spatial tasks separating cue conditions that either favored female or male strategies would examine this structure-function correlation with greater precision. Previous work suggests that males are better in the use of directional cues than females. In the present study, participants learned a target location in a virtual landscape environment, in conditions that contained either all directional (i.e., distant or compass bearing) cues, or all positional (i.e., local, small objects) cues. After a short delay, participants navigated back to the target location from a novel starting location. Males had higher accuracy in initial search direction than females in environments with all directional cues. Lower digit ratio was correlated with higher accuracy of initial search direction in females in environments with all directional cues. Mental rotation scores did not correlate with digit ratio in either males or females. These results demonstrate for the first time that a sex difference in the use of directional cues, i.e., the sense of direction, is associated with more male-like digit ratio.National Science Foundation (U.S.) (NSF ECCS-1028319)National Science Foundation (U.S.) (NSF Graduate Student Fellowship)Mary Elisabeth Rennie Endowment for Epilepsy Researc

Zebrafish: a vertebrate tool for studying basal body biogenesis, structure, and function.

Understanding the role of basal bodies (BBs) during development and disease has been largely overshadowed by research into the function of the cilium. Although these two organelles are closely associated, they have specific roles to complete for successful cellular development. Appropriate development and function of the BB are fundamental for cilia function. Indeed, there are a growing number of human genetic diseases affecting ciliary development, known collectively as the ciliopathies. Accumulating evidence suggests that BBs establish cell polarity, direct ciliogenesis, and provide docking sites for proteins required within the ciliary axoneme. Major contributions to our knowledge of BB structure and function have been provided by studies in flagellated or ciliated unicellular eukaryotic organisms, specifically Tetrahymena and Chlamydomonas. Reproducing these and other findings in vertebrates has required animal in vivo models. Zebrafish have fast become one of the primary organisms of choice for modeling vertebrate functional genetics. Rapid ex-utero development, proficient egg laying, ease of genetic manipulation, and affordability make zebrafish an attractive vertebrate research tool. Furthermore, zebrafish share over 80 % of disease causing genes with humans. In this article, we discuss the merits of using zebrafish to study BB functional genetics, review current knowledge of zebrafish BB ultrastructure and mechanisms of function, and consider the outlook for future zebrafish-based BB studies

Validation of <i>N</i>-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of <i>Trypanosoma cruzi</i>

BACKGROUND:Trypanosoma cruzi causes Chagas disease, an endemic and debilitating illness in Latin America. Lately, owing to extensive population movements, this neglected tropical disease has become a global health concern. The two clinically available drugs for the chemotherapy of Chagas disease have rather high toxicity and limited efficacy in the chronic phase of the disease, and may induce parasite resistance. The development of new anti-T. cruzi agents is therefore imperative. The enzyme N-myristoyltransferase (NMT) has recently been biochemically characterized, shown to be essential in Leishmania major, Trypanosoma brucei, and T. cruzi¸ and proposed as promising chemotherapeutic target in these trypanosomatids. METHODOLOGY/PRINCIPAL FINDINGS:Here, using high-content imaging we assayed eight known trypanosomatid NMT inhibitors, against mammal-dwelling intracellular amastigote and trypomastigote stages and demonstrated that three of them (compounds 1, 5, and 8) have potent anti-proliferative effect at submicromolar concentrations against T. cruzi, with very low toxicity against human epithelial cells. Moreover, metabolic labeling using myristic acid, azide showed a considerable decrease in the myristoylation of proteins in parasites treated with NMT inhibitors, providing evidence of the on-target activity of the inhibitors. CONCLUSIONS/SIGNIFICANCE:Taken together, our data point out to the potential use of NMT inhibitors as anti-T. cruzi chemotherapy

Groundwater, geothermal modelling and monitoring at city-scale : reviewing European practice and knowledge exchange : TU1206 COST sub-urban WG2 report

The need for cities to make more effective use of the subsurface on which they stand, is increasingly being recognised in Europe and further afield to be essential for future cities to be sustainable and more resilient [1,2]. However, city planning worldwide remains largely 2D, with very few cities having any substantial subsurface planning or Masterplans – the cities of Helsinki, Montreal, Singapore being rare exceptions [3,4]. The consequences of inadequate consideration and planning of the subsurface are far-reaching, in economic, environmental and social terms. Across Europe, poor understanding of ground conditions is recognised as the largest single cause of construction project delay and overspends [5]. Management of urban groundwater and shallow geothermal energy resources is becoming increasingly important as cities are increasingly looking to use these resources to meet current and future energy and heating and water needs. Whilst these are, alongside potential underground building space, the two most important resources for future cities, the monitoring and regulation of these resource is widely variable across Europe. For subsurface opportunities such as groundwater and geothermal energy to be realised and utilised to greatest effect to support growing city populations and infrastructure, city planners must be both aware of, and have some understanding of the resources, available data and research, and both the opportunities and risks which the resources provide to city development [6,7]. To supply this understanding to city municipalities and others, geological surveys must have robust datasets of groundwater and geothermal resources at city-scale, and the relevant knowledge and understanding from these data must be made accessible to inform subsurface planning in appropriate datasets relevant to different scale of interest in different planning stages. What density and frequency of data are required for a robust understanding of a city’s groundwater and geothermal resources will be different in different cities, according to the complexity of the resources, and the intensity of subsurface use and demands on the resources. Indeed, no one design of city-scale monitoring or modelling of ground-water and -heat resources is appropriate for all cities, or for all monitoring objectives. However, the guiding principles of good practice for developing robust city-scale monitoring, and datasets are widely applicable, as are the key principles for ensuring these data inform city planning processes. This report provides an initial review of existing examples of current practices in Europe with respect to groundwater and geothermal monitoring and modelling, as a resource for other cities to learn from and build upon. The report also provides an overview of some of the different practices used for communicating groundwater and geothermal energy data and knowledge to inform urban planning and managemen