Directionality of an optical fiber high-frequency acoustic sensor for partial discharge detection and location

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Tunable dual-wavelength picosecond pulse generation by the use of two Fabry-Pérot laser diodes in an external injection seeding scheme

Author name used in this publication: W. JinAuthor name used in this publication: M. S. DemokanAuthor name used in this publication: D. N. Wang2001-2002 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Dual-wavelength ultra-short pulse generation by use of semiconductor laser diode

2002-2003 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Two-mode operation in highly birefringent photonic crystal fiber

Abstract-A photonic crystal fiber with different air-hole diameters along the orthogonal axes is found to support only the first two modes over a very broad wavelength range ( 650 nm). The second-order mode is approximately linearly polarized and has stable-intensity lope positions that do not change in response to environmental disturbances. Strain sensitivity as a function of operating wavelength of a two-mode interferometric sensor made from such a fiber is also investigated. Index Terms-Finite-element method (FEM), photonic crystal fiber (PCF), two-mode fiber

Modulational instability in a fiber soliton ring laser induced by periodic dispersion variation

Modulational instability with sideband generation is experimentally observed in a passively mode-locked fiber soliton ring laser. We show numerically that this modulational instability is induced by the periodic dispersion variation experienced by light circulating in the laser cavity. Modulational instability caused by cross-phase-modulation is also observed in the laser and confirmed numerically

Comparison of Promoter Hypermethylation Pattern in Salivary Rinses Collected with and without an Exfoliating Brush from Patients with HNSCC

Background: Salivary rinses have been recently proposed as a valuable resource for the development of epigenetic biomarkers for detection and monitoring of head and neck squamous cell carcinoma (HNSCC). Both salivary rinses collected with and without an exfoliating brush from patients with HNSCC are used in detection of promoter hypermethylation, yet their correlation of promoter hypermethylation has not been evaluated. This study was to evaluate the concordance of promoter hypermethylation between salivary rinses collected with and without an exfoliating brush from patients with HNSCC. Methodolgy: 57 paired salivary rinses collected with or without an exfoliating brush from identical HNSCC patients were evaluated for promoter hypermethylation status using Quantitative Methylation-Specific PCR. Target tumor suppressor gene promoter regions were selected based on our previous studies describing a panel for HNSCC screening an

Promoter DNA Methylation of Oncostatin M receptor-β as a Novel Diagnostic and Therapeutic Marker in Colon Cancer

In addition to genetic changes, the occurrence of epigenetic alterations is associated with accumulation of both genetic and epigenetic events that promote the development and progression of human cancer. Previously, we reported a set of candidate genes that comprise part of the emerging “cancer methylome”. In the present study, we first tested 23 candidate genes for promoter methylation in a small number of primary colon tumor tissues and controls. Based on these results, we then examined the methylation frequency of Oncostatin M receptor-β (OSMR) in a larger number of tissue and stool DNA samples collected from colon cancer patients and controls. We found that OSMR was frequently methylated in primary colon cancer tissues (80%, 80/100), but not in normal tissues (4%, 4/100). Methylation of OSMR was also detected in stool DNA from colorectal cancer patients (38%, 26/69) (cut-off in TaqMan-MSP, 4). Detection of other methylated markers in stool DNA improved sensitivity with little effect on specificity. Promoter methylation mediated silencing of OSMR in cell lines, and CRC cells with low OSMR expression were resistant to growth inhibition by Oncostatin M. Our data provide a biologic rationale for silencing of OSMR in colon cancer progression and highlight a new therapeutic target in this disease. Moreover, detection and quantification of OSMR promoter methylation in fecal DNA is a highly specific diagnostic biomarker for CRC