Strengthen Privacy by Policy Generation & Secure Access on Content Sharing Sites

Creating privacy controls for social networks that are both expressive and usable is a major challenge. Lack of user understanding of privacy settings can lead to unwanted disclosure of private information and, in some cases, to material harm. In light of these incidents, the need of tools to help users control access to their shared content is apparent. Toward addressing this need, we propose a Policy Hardening system to help users compose privacy settings for not only their images but securing each and every type of uploaded file. Dynamic groups are generated with particular policies of each group for secure access of files. We examine the role of social context, file content, and policies as possible indicators of users� privacy preferences. We propose a policy framework where user can upload all kind of files and provide different policies with different users

QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP ANALYSIS OF NOVEL PYRAZOLINE DERIVATIVES USING K NEAREST NEIGHBOUR MOLECULAR FIELD ANALYSIS METHOD

Objective: Malonyl CoA decarboxylase (MCD) enzyme plays important role in fatty acid and glucose oxidation. Inhibition of MCD might turn to a novel approach to treat ischemia. The main objective of this research article was to develop a novel pharmacophore for enhanced activity.Methods: Three-dimensional quantitative structure-activity relationships (3D-QSAR) was performed for pyrazoline derivatives as MCD inhibitors using VLife MDS 4.6 software. The QSAR model was developed using the stepwise 3D-QSAR kNN-MFA method.Results: The statistical results generated from kNN-MFA method indicated the significance and requirements for better MCD inhibitory activity. The information rendered by 3D-QSAR model may render to better understanding and designing of novel MCD inhibitors.Conclusion: 3D-QSAR is an important tool in understanding the structural requirements for the design of novel and potent MCD inhibitors. It can be employed to design new drug discovery

ϕ\phi- meson Production at RHIC energies using the PHENIX Detector

Light vector mesons are among the most informative probes to understand the strongly coupled Quark Gluon Plasma created at RHIC. The suppression of light mesons at high transverse momentum, compared to expectations from scaled $p+p$ results, reflects the properties of the strongly interacting matter formed. The $\phi$-meson is one of the probes whose systematic measurement in $p+p$, $d+Au$ and $Au+Au$ collisions can provide useful information about initial and final state effects on particle production. The mass, width and branching ratio of the $\phi$-meson decay in the di-kaon and di-electron decay channels could be modified in \au collisions due to the restoration of chiral symmetry in the QGP. The PHENIX experiment at RHIC has measured $\phi$-meson production in various systems ranging form $p+p$, $d+Au$ to $Au+Au$ collisions via both its di-electron and di-kaon decay modes. A summary of PHENIX results on invariant spectra, nuclear modification factor and elliptic flow of the $\phi$-meson are presented here

Comparative analysis of maternal and fetal outcome in meconium stained amniotic fluid and clear liquor in primigravida

Background: The present study was undertaken to evaluate the significance of MSAF and its fetal outcome in parturients.Methods: A total of 121 pregnant women who had completed more than 37 weeks of gestation with live singleton pregnancy, spontaneous onset of labor and at term with adequate pelvis were included in the study. All (121) low risk primigravida with MSAF were studied to identify maternal and fetal outcome and compared with equal number of cases with clear amniotic fluid. Meconium stained cases were clinically classified into two groups- thin (54 cases) and thick (67 cases). MSAF on spontaneous or artificial rupture of membranes were monitored with fetal heart rate abnormality, 1- and 5-minutes Apgar score, NICU admissions and neonatal complications as outcome variables.Results: Overall incidence of meconium staining of AF during labour was 7.71%. The common fetal heart rate abnormalities i.e. bradycardia was seen in 36% in MSG. Apgar score of less than 7 was observed in MSG at 5 minutes in 5% of cases, in thick group. Major neonatal complication was birth asphyxia in MSG (18.18%) that was more in thick MSG (14.87%). MAS were observed in 6 cases in thick and 4 cases in thin meconium stained cases. NICU care was required in 18% cases in MSG and in control group it was required in 7% cases. Neonatal morbidity was more in newborn with thick meconium group (52%) compared to thin meconium group (20%).Conclusions: The present study confirmed that meconium staining of amniotic fluid adversely influences the fetal outcome

Role of diagnostic hysteroscopy in evaluating patients with abnormal uterine bleeding in a tertiary care centre

Background: Abnormal uterine bleeding is one of the commonest conditions amongst patients attending gynaecology OPD which also leads to significant disruption in a normal lifestyle. The causes of abnormal uterine bleeding are heterogeneous and complex. A systematic evaluation with detailed history and physical examination is foremost important in reaching diagnosis. Hysteroscopy is not only safe, quick and observes entire uterine cavity but also helps in precision in sampling and increases accuracy of diagnosis. It is also curative in conditions such as polyps, fibroids, uterine synechiae, menorrhagia and lost intrauterine contraceptive device. The aim of the study is to evaluate the role of hysteroscopy as a screening method in patients with AUB & compare to their USG findings and to the histopathological reports of the endometrial biopsy.Methods: This is a prospective observational study conducted at a tertiary healthcare centre over a period of 18 months, in 50 females belonging to pre, peri and post-menopausal age group. Sampling was done based on selection criteria after obtaining valid consent from the study group.Results: Hysteroscopy has a definitive role in evaluation of patients presenting with abnormal uterine bleeding with high sensitivity, specificity, PPV and NPV with immediate results.Conclusions: The above study concludes that the accuracy of diagnosing the cause of abnormal uterine bleeding is more with hysteroscopy followed by D and C then USG combined with D and C

Childhood Trauma and PTSD symptoms: Disentangling the Roles of Emotion Regulation and Distress Tolerance

Background: Research documents that individuals with a history of childhood trauma experience greater emotion regulation difficulties (ED), as well as lower distress tolerance (DT), two constructs that independent lines of research implicate as transdiagnostic factors in post-traumatic stress disorder (PTSD). To help elucidate how such mechanisms may influence the etiology, maintenance, and treatment of PTSD, the current study investigates the distinct mediating roles of ED and DT and explores which accounts for more unique variance. Methods: Participants (N = 385, aged 18-48) with a childhood trauma history provided self-ratings of cumulative trauma exposure, and endorsed current ED, DT, and PTSD symptoms. Single and dual mediation analyses were conducted to assess the roles of ED and DT in the relation between childhood trauma exposure and current PTSD symptoms. Results: ED and DT were inversely related. Higher childhood trauma exposure predicted higher PTSD symptoms in adulthood. ED and DT each mediated/explained the association between childhood trauma exposure and current PTSD symptoms; ED accounted for a larger effect size. Limitations: Cross-sectional design precludes determining causality. Retrospective self-report in measurement is subject to bias and findings may not generalize to behavioral measures. Conclusions: The current study results provide preliminary evidence of ED and DT as distinct mechanisms. Of clinical relevance, current findings support post-trauma processing theories that contend individuals’ recovery requires accepting and learning to modulate trauma-related emotional states. Implications for potential pathways from childhood trauma to PTSD, as well as methods of treatment and prevention are discussed

E-learning – An Indian Perceptive

E-learning is the backbone of every developing country. E-learning plays a very important role in the development of country. This paper focuses growth of e-learning in India and its impact on the development of India. E-learning helps in the development of country and also it helps everyone to study those who are willing to as it offers anytime anywhere. E-learning has become an important part of the society, comprising an extensive array of digitalization approaches, components and delivery methods. The use of information and communication technologies (ICT) for educational purpose has increased, & the spread of network technologies has caused e-learning practices to evolve significantly

A clinical study of arrhythmias associated with acute myocardial infarction and thrombolysis

Background: Arrhythmias are a common occurrence in ACS. This study was undertaken to analyze the incidence, frequency and type of arrhythmias in relation to the site of infarction to aid in timely intervention to modify the outcome in MI and to study the significance of Reperfusion arrhythmias.Methods: 100 patients were evaluated. ECG and cardiac enzymes were studied. Arrhythmias complicating AMI in terms of their incidence, timing, severity, type, relation, reperfusion and results were studied.Results: Of the 100 cases, 74% were males and 26% females of which incidence being common between 4th to 7th decades of life. AMI was common in patients with Diabetes and Hypertension (23% each). Incidence of AWMI (58%) is higher than IWMI (40%). Out of all arrhythmias, Ventricular Tachycardia was seen in 24% cases with 50% mortality and preponderance to Antero Lateral Myocardial Infarction. Sinus Tachycardia was seen in 23% of cases with preponderance to Antero Lateral Myocardial Infarction and persistence of Sinus Tachycardia was a prognostic sign, mortality being 22%. Complete Heart Block and Sinus Bradycardia were seen with IWMI, incidence being 53.8% and 100% respectively. Bundle Branch Block was common in AWMI (31%) than IWMI (10%). Among 64 thrombo-lysed cases, 21 had Reperfusion Arrhythmias without any mortality, whereas remaining 43 without Reperfusion Arrhythmias had mortality of 18.6%.Conclusions: According to the study, Tachy-arrhythmias are common with Anterior Wall Myocardial Infarction and Brady-arrhythmias in Inferior Wall Myocardial Infarction. Reperfusion Arrhythmias are a benign phenomenon and good indicator of successful reperfusion

Posterior Approach To Kidney Dissection: An Old Surgical Approach For Integrated Medical Curricula

Integrated medical curricular changes are altering the historical regional anatomy approach to abdominal dissection. The renal system is linked physiologically and biochemically to the cardiovascular and respiratory systems, yet anatomist often approach the urinary system as part of the abdomen and pelvic regions. As part of an integrated curriculum, the renal system must be covered relatively quickly after the thorax in the cadaver lab, often without the opportunity to fully appreciate the rest of the abdominal contents. This paper provides dissection instructions that follow the one of the historical surgical approaches for nephrectomy, including preservation of the posterior abdominal wall neurovasclature. Dissection procedures were developed for first year medical students, intending this posterior approach to the kidneys to be their first introduction to the renal system. It has been successfully implemented with first year medical students at the University of New England, College of Osteopathic Medicine. Utilizing this posterior approach to the kidney enabled the study of the anatomy of the kidneys, suprarenal glands and renal vessels, as well as the muscles of the lumbar spine, while maintaining the integrity of the anterior abdominal wall and peritoneal cavity for future gastrointestinal and reproductive system-based dissections