Perceptual lossless medical image coding

A novel perceptually lossless coder is presented for the compression of medical images. Built on the JPEG 2000 coding framework, the heart of the proposed coder is a visual pruning function, embedded with an advanced human vision model to identify and to remove visually insignificant/irrelevant information. The proposed coder offers the advantages of simplicity and modularity with bit-stream compliance. Current results have shown superior compression ratio gains over that of its information lossless counterparts without any visible distortion. In addition, a case study consisting of 31 medical experts has shown that no perceivable difference of statistical significance exists between the original images and the images compressed by the proposed coder

Stereological Analysis of Neuron, Glial and Endothelial Cell Numbers in the Human Amygdaloid Complex

Cell number alterations in the amygdaloid complex (AC) might coincide with neurological and psychiatric pathologies with anxiety imbalances as well as with changes in brain functionality during aging. This stereological study focused on estimating, in samples from 7 control individuals aged 20 to 75 years old, the number and density of neurons, glia and endothelial cells in the entire AC and in its 5 nuclear groups (including the basolateral (BL), corticomedial and central groups), 5 nuclei and 13 nuclear subdivisions. The volume and total cell number in these territories were determined on Nissl-stained sections with the Cavalieri principle and the optical fractionator. The AC mean volume was 956 mm3 and mean cell numbers (x106) were: 15.3 neurons, 60 glial cells and 16.8 endothelial cells. The numbers of endothelial cells and neurons were similar in each AC region and were one fourth the number of glial cells. Analysis of the influence of the individuals’ age at death on volume, cell number and density in each of these 24 AC regions suggested that aging does not affect regional size or the amount of glial cells, but that neuron and endothelial cell numbers respectively tended to decrease and increase in territories such as AC or BL. These accurate stereological measures of volume and total cell numbers and densities in the AC of control individuals could serve as appropriate reference values to evaluate subtle alterations in this structure in pathological conditions

Perceptually lossless medical image coding and its significance in telemedical applications

A method of encoding medical images to a perceptually lossless quality is presented in this paper. It employs a model of human vision, such that only visually insignif icant/irrelevant information is removed. Current results have shown that it yields greater compression ratio gains over its lossless counterparts without inducing any visible loss in picture quality, which has been veri?ed with 31 medical experts. This is essential in telemedical applica tions, especially when there is a limitation in network trans mission bandwidth. This method can be embedded into any Wavelet based image coder without affecting its bit-stream compliance and therefore specialised decoders are not required

Performance evaluation of a perceptually lossless medical image coder

How to deliver clinically critical information in a 'smaller package'? This paper evaluates a recently proposed perceptually lossless medical image coder (PLMIC) based on the JPEG2000 coding framework. A performance comparison is made between the PLMIC and two benchmark coders LOCO-I and near lossless LOCO-I at two levels in terms of compression ratio and picture fidelity. Subjective assessment in this instance has been carried out with 31 medical experts. The results have shown that the PLMIC delivers significantly higher compression ratio performance than that of the state-of-the-art JPEG-LS LOCO-I lossless algorithm without any visible degradation in image quality or clinical information

Chemical Validation of Phosphodiesterase C as a Chemotherapeutic Target in Trypanosoma Cruzi, the Etiological Agent of Chagas\u27 Disease

Trypanosoma cruzi phosphodiesterase (PDE) C (TcrPDEC), a novel and rather unusual PDE in which, unlike all other class I PDEs, the catalytic domain is localized in the middle of the polypeptide chain, is able to hydrolyze cyclic GMP (cGMP), although it prefers cyclic AMP (cAMP), and has a FYVE-type domain in its N-terminal region (S. Kunz et al., FEBS J. 272:6412-6422, 2005). TcrPDEC shows homology to the mammalian PDE4 family members. PDE4 inhibitors are currently under development for the treatment of inflammatory diseases, such as asthma, chronic pulmonary diseases, and psoriasis, and for treating depression and serving as cognitive enhancers. We therefore tested a number of compounds originally synthesized as potential PDE4 inhibitors on T. cruzi amastigote growth, and we obtained several useful hits. We then conducted homology modeling of T. cruzi PDEC and identified other compounds as potential inhibitors through virtual screening. Testing of these compounds against amastigote growth and recombinant TcrPDEC activity resulted in several potent inhibitors. The most-potent inhibitors were found to increase the cellular concentration of cAMP. Preincubation of cells in the presence of one of these compounds stimulated volume recovery after hyposmotic stress, in agreement with their TcrPDEC inhibitory activity in vitro, providing chemical validation of this target. The compounds found could be useful tools in the study of osmoregulation in T. cruzi. In addition, their further optimization could result in the development of new drugs against Chagas\u27 disease and other trypanosomiases