Ovarian cancer - diagnosis and management

Copyright to Australian Family Physician. Reproduced with permission. Permission to reproduce must be sought from the publisher, The Royal Australian College of General Practitioners.BACKGROUND Epithelial ovarian cancer presents most often as late stage disease due to a lack of effective screening tests and vagueness of symptoms. OBJECTIVE This article outlines the diagnosis and management of ovarian cancer. DISCUSSION Women with suspected ovarian cancer are best managed in a gynaecological treatment unit offering multidisciplinary care. Surgery is usually needed both to make a diagnosis and for definitive treatment and referral to a specialty trained gynaecological oncologist is appropriate. Most women will also require chemotherapy. Ovarian cancers have good sensitivity to several drugs but relapse rates are high. This means that ovarian cancer is now seen as a chronic disease with often several episodes of remission, relapse and treatment. The psychological impact of this diagnosis both on the woman and her family are significant and best dealt with proactively.Margaret Dav

Maximum likelihood parameter estimation for latent variable models using sequential Monte Carlo

We present a sequential Monte Carlo (SMC) method for maximum likelihood (ML) parameter estimation in latent variable models. Standard methods rely on gradient algorithms such as the Expectation- Maximization (EM) algorithm and its Monte Carlo variants. Our approach is different and motivated by similar considerations to simulated annealing (SA); that is we propose to sample from a sequence of artificial distributions whose support concentrates itself on the set of ML estimates. To achieve this we use SMC methods. We conclude by presenting simulation results on a toy problem and a nonlinear non-Gaussian time series model

MOT meets AHA!

MOT (My Online Teacher) is an adaptive hypermedia system (AHS) web-authoring environment. MOT is now being further developed according to the LAOS five-layer adaptation model for adaptive hypermedia and adaptive web-material, containing a domain -, goal -, user -, adaptation – and presentation model. The adaptation itself follows the LAG three-layer granularity structure, figuring direct adaptation techniques and rules, an adaptation language and adaptation strategies. In this paper we shortly describe the theoretical basis of MOT, i.e., LAOS and LAG, and then give some information about the current state of MOT. The purpose of this paper is to show how we plan the design and development of MOT and the well-known system AHA! (Adaptive Hypermedia Architecture), developed at the Technical University of Eindhoven since 1996. We aim especially at the integration with AHA! 2.0. Although AHA! 2.0 represents a progress when compared to the previous versions, a lot of adaptive features that are described by the LAOS and the adaptation granulation model and that are being implemented into MOT are not yet (directly) available. So therefore AHA! can benefit from MOT. On the other hand, AHA! offers a running platform for the adaptation engine, which can benefit MOT in return

Observation of Foliage-roosting in the Little Brown Bat, Myotis lucifugus

First report of foliage-roosting behaviour in a Little Brown Bat (Myotis lucifus). The observation is discussed in relation to similar behaviour in other bat species

Keck Imaging of Binary L Dwarfs

We present Keck near-infrared imaging of three binary L dwarf systems, all of which are likely to be sub-stellar. Two are lithium dwarfs, and a third exhibits an L7 spectral type, making it the coolest binary known to date. All have component flux ratios near 1 and projected physical separations between 5 and 10 AU, assuming distances of 18 to 26 pc from recent measurements of trigonometric parallax. These surprisingly similar binaries represent the sole detections of companions in ten L dwarf systems which were analyzed in the preliminary phase of a much larger dual-epoch imaging survey. The detection rate prompts us to speculate that binary companions to L dwarfs are common, that similar-mass systems predominate, and that their distribution peaks at radial distances in accord both with M dwarf binaries and with the radial location of Jovian planets in our own solar system. To fully establish these conjectures against doubts raised by biases inherent in this small preliminary survey, however, will require quantitative analysis of a larger volume-limited sample which has been observed with high resolution and dynamic range.Comment: LaTex manuscript in 13 pages, 3 postscript figures, Accepted for publication in the Letters of the Astrophysical Journal; Postscript pre-print version available at: http://www.hep.upenn.edu/PORG/papers/koerner99a.p

Discovery of an M9.5 Candidate Brown Dwarf in the TW Hydrae Association - DENIS J124514.1-442907

We report the discovery of a fifth candidate substellar system in the ~5-10 Myr TW Hydrae Association - DENIS J124514.1-442907. This object has a NIR spectrum remarkably similar to that of 2MASS J1139511-315921, a known TW Hydrae brown dwarf, with low surface gravity features such as a triangular-shaped H-band, deep H2O absorption, weak alkali lines, and weak hydride bands. We find an optical spectral type of M9.5 and estimate a mass of <24 M_Jup, assuming an age of ~5-10 Myr. While the measured proper motion for DENIS J124514.1-442907 is inconclusive as a test for membership, its position in the sky is coincident with the TW Hydrae Association. A more accurate proper motion measurement, higher resolution spectroscopy for radial velocity, and a parallax measurement are needed to derive the true space motion and to confirm its membership.Comment: 8 pages - emulateapj style, 2 figures, 3 tables. Accepted to ApJL. Fixed typos, added reference, added footnot