Centaurea triumfetii essential oil chemical composition, comparative analysis, and antimicrobial activity of selected compounds

The essential oils from the Centaurea genus are well known for their pharmacological properties. The most abundant and dominant chemical components in Centaurea essential oils are ß-caryophyllene, hexadecanoic acid, spathulenol, pentacosane, caryophyllene oxide, and phytol. However, whether these dominant components are the key drivers for observed antimicrobial activity remains unclear. Thus, the aim of this study was dual. Here we provide comprehensive, literature-based data to correlate the chemical compounds in Centaurea essential oils with the tested antimicrobial activity. Secondly, we characterized the essential oil of Centaurea triumfettii All. squarrose knapweed using coupled system gas chromatography-mass spectrometry and tested its phytochemicals for antimicrobial activity against E. coli and S. epidermis using disc diffusion assay and monitoring their growth in Muller Hinton broth. The most abundant compounds in C. triumfettii essential oil were hexadecanoic acid (11.1%), spathulenol (10.8%), longifolene (8.8%), germacrene D (8.4%), aromadendrene oxide (6.0%) and linoleic acid (5.3%). Based on our analysis of literature data from other Centaurea essential oils, they were positively correlated with antimicrobial activity. Using an agar disk diffusion method, tested chemical constituents did not show experimental evidence to support this positive correlation to antimicrobial activity when we tested them as pure components. The antibacterial effect of essential oil constituents may be related to a complex synergistic, rather than a single component as suggested by performed network pharmacology analysis, underlying the theoretical interactions between the essential oil phytochemicals listed as potentially responsible for antimicrobial activity and should be confirmed in further in-depth studies. This is the first report on the comparative analysis of Centaurea essential oils with good antimicrobial activity, as well as the first analysis of chemical components of the essential oil from C. triumfettii and the first report of antimicrobial activity of the representative, pure components: aromadendrene, germacrene D, spathulenol, longifolene, and the mixture of selected chemical compounds. This work contributes to the body of knowledge on the genus Centaurea and C. triumfettii species

Isospin dependence of relative yields of K+K^+ and K0K^0 mesons at 1.528 AGeV

Results on $K^+$ and $K^0$ meson production in $^{96}_{44}$Ru + $^{96}_{44}$Ru and $^{96}_{40}$Zr + $^{96}_{40}$Zr collisions at a beam kinetic energy of 1.528$A$ GeV, measured with the FOPI detector at GSI-Darmstadt, are investigated as a possible probe of isospin effects in high density nuclear matter. The measured double ratio ($K^+/K^0$)$_{Ru}$/($K^+/K^0$)$_{Zr}$ is compared to the predictions of a thermal model and a Relativistic Mean Field transport model using two different collision scenarios and under different assumptions on the stiffness of the symmetry energy. We find a good agreement with the thermal model prediction and the assumption of a soft symmetry energy for infinite nuclear matter while more realistic transport simulations of the collisions show a similar agreement with the data but also exhibit a reduced sensitivity to the symmetry term.Comment: 5 pages, 3 figures. accepted for publication in Phys. Rev.

Two-proton small-angle correlations in central heavy-ion collisions: a beam-energy and system-size dependent study

Small-angle correlations of pairs of protons emitted in central collisions of Ca + Ca, Ru + Ru and Au + Au at beam energies from 400 to 1500 MeV per nucleon are investigated with the FOPI detector system at SIS/GSI Darmstadt. Dependences on system size and beam energy are presented which extend the experimental data basis of pp correlations in the SIS energy range substantially. The size of the proton-emitting source is estimated by comparing the experimental data with the output of a final-state interaction model which utilizes either static Gaussian sources or the one-body phase-space distribution of protons provided by the BUU transport approach. The trends in the experimental data, i.e. system-size and beam energy dependences, are well reproduced by this hybrid model. However, the pp correlation function is found rather insensitive to the stiffness of the equation of state entering the transport model calculations.Comment: 9 pages, 8 figures, accepted at Eur. Phys. Journ.

Charged pion production in 4496^{96}_{44}Ru+4496^{96}_{44}Ru collisions at 400A and 1528A MeV

We present transverse momentum and rapidity spectra of charged pions in central Ru + Ru collisions at 400$A$ and 1528$A$ MeV. The data exhibit enhanced production at low transverse momenta compared to the expectations from the thermal model that includes the decay of $\Delta(1232)$-resonances and thermal pions. Modification of the $\Delta$-spectral function and the Coulomb interaction are necessary to describe the detailed shape of the transverse momentum spectra. Within the framework of the thermal model, the freeze-out radii of pions are similar at both beam energies. The IQMD model reproduces the shapes of the transverse momentum and rapidity spectra of pions, but the predicted absolute yields are larger than in the measurements, especially at lower beam energy.Comment: 12 pages, 11 figure

Direct comparison of phase-space distributions of K- and K+ mesons in heavy-ion collisions at SIS energies - evidence for in-medium modifications of kaons ?

The ratio of K- to K+ meson yields has been measured in the systems RuRu at 1.69 A GeV, Ru+Zr at 1.69 A GeV, and Ni+Ni at 1.93 A GeV incident beam kinetic energy. The yield ratio is observed to vary across the measured phase space. Relativistic transport-model calculations indicate that the data are best understood if in-medium modifications of the kaons are taken into account.Comment: 14 pages including 3 figure

Centrality dependence of subthreshold ϕ\phi meson production in Ni+Ni collisions at 1.9A GeV

We analysed the $\phi$ meson production in central Ni+Ni collisions at the beam kinetic energy of 1.93A GeV with the FOPI spectrometer and found the production probability per event of $[8.6 ~\pm~ 1.6 ~(\text{stat}) \pm 1.5 ~(\text{syst})] \times 10^{-4}$. This new data point allows for the first time to inspect the centrality dependence of the subthreshold $\phi$ meson production in heavy-ion collisions. The rise of $\phi$ meson multiplicity per event with mean number of participants can be parameterized by the power function with exponent $\alpha = 1.8 \pm 0.6$. The ratio of $\phi$ to $\text{K}^-$ production yields seems not to depend within the experimental uncertainties on the collision centrality, and the average of measured values was found to be $0.36 \pm 0.05$.Comment: 9 pages, 5 figure

Strange meson production in Al+Al collisions at 1.9A GeV

The production of K$^+$, K$^-$ and $\varphi$(1020) mesons is studied in Al+Al collisions at a beam energy of 1.9A GeV which is close or below the production threshold in NN reactions. Inverse slopes, anisotropy parameters, and total emission yields of K$^{\pm}$ mesons are obtained. A comparison of the ratio of kinetic energy distributions of K$^-$ and K$^+$ mesons to the HSD transport model calculations suggests that the inclusion of the in-medium modifications of kaon properties is necessary to reproduce the ratio. The inverse slope and total yield of $\phi$ mesons are deduced. The contribution to K$^-$ production from $\phi$ meson decays is found to be [17 $\pm$ 3 (stat) $^{+2}_{-7}$ (syst)] %. The results are in line with previous K$^{\pm}$ and $\phi$ data obtained for different colliding systems at similar incident beam energies.Comment: 16 pages, 11 figure

Measurement of K∗(892)0K^*(892)^0 and K0K^0 mesons in Al+Al collisions at 1.9AA GeV

New measurement of sub-threshold $K^*(892)^0$ and $K^0$ production is presented. The experimental data complete the measurement of strange particles produced in Al+Al collisions at 1.9$A$ GeV measured with the FOPI detector at SIS/GSI. The $K^*(892)^0$ / $K^0$ yield ratio is found to be $0.0315\pm 0.006 (\mathrm{stat.})\pm 0.012 (\mathrm{syst.})$ and is in good agreement with the UrQMD model prediction. These measurements provide information on in-medium cross section of $K^+$ - $\pi^-$ fusion which is the dominant process on sub-threshold $K^*(892)^0$ production.Comment: 5 pages, 4 figures, accepted for publication in Phys. Rev.

Sideward flow of K+ mesons in Ru+Ru and Ni+Ni reactions near threshold

Experimental data on K+ meson and proton sideward flow measured with the FOPI detector at SIS/GSI in the reactions Ru+Ru at 1.69 AGeV and Ni+Ni at 1.93 AGeV are presented. The K+ sideward flow is found to be anti-correlated (correlated) with the one of protons at low (high) transverse momenta. When compared to the predictions of a transport model, the data favour the existence of an in-medium repulsive K+ nucleon potential.Comment: 16 pages Revtex, 3 ps-figures, submitted to Phys. Lett.

Flow angle from intermediate mass fragment measurements

Directed sideward flow of light charged particles and intermediate mass fragments was measured in different symmetric reactions at bombarding energies from 90 to 800 AMeV. The flow parameter is found to increase with the charge of the detected fragment up to Z = 3-4 and then turns into saturation for heavier fragments. Guided by simple simulations of an anisotropic expanding thermal source, we show that the value at saturation can provide a good estimate of the flow angle, $\Theta_{flow}$, in the participant region. It is found that $\Theta_{flow}$ depends strongly on the impact parameter. The excitation function of $\Theta_{flow}$ reveals striking deviations from the ideal hydrodynamical scaling. The data exhibit a steep rise of \Theta_{\flow} to a maximum at around 250-400 AMeV, followed by a moderate decrease as the bombarding energy increases further.Comment: 28 pages Revtex, 6 figures (ps files), to appear in Nucl.Phys.