International Violence Against Women: U.S. Response and Policy Issues

[Excerpt] In recent years, the international community has increasingly recognized international violence against women (VAW) as a significant human rights and global health issue. VAW, which can include both random acts of violence as well as sustained abuse over time, can be physical, psychological, or sexual in nature. Studies have found that VAW occurs in all geographic regions, countries, cultures, and economic classes, with some research showing that women in developing countries experience higher rates of violence than those in developed countries. Many experts view VAW as a symptom of the historically unequal power relationship between men and women,and argue that over time this imbalance has led to pervasive cultural stereotypes and attitudes that perpetuate a cycle of violence. This report addresses causes, prevalence, and consequences of violence against women. It provides examples of completed and ongoing U.S. activities that address VAW directly or include anti-VAW components, and it outlines possible policy issues for the 112th Congress, including • the scope and effectiveness of U.S. programs in addressing international VAW; • further integrating anti-VAW programs into U.S. assistance and foreign policy mechanisms; • U.S. funding for anti-VAW activities worldwide, particularly in light of the global financial crisis, economic recession, and subsequent calls to reduce the U.S. budget deficit; and • strengthening U.S. government coordination of anti-VAW activities

Resource partitioning among top-level piscivores in a sub-Arctic lake during thermal stratification

AbstractIn systems with multiple piscivores, co-occurrence is dependent on resource partitioning. This is pronounced in oligotrophic northern lakes, which have simple food webs and short open-water seasons. We used acoustic telemetry and stable isotopes to quantify habitat and dietary partitioning during thermal stratification among three piscivores that commonly co-occur in Canadian sub-Arctic lakes—burbot (Lota lota), lake trout (Salvelinus namaycush), and northern pike (Esox lucius). Spatial core areas and core habitat niches (space and depth) did not significantly overlap among species. Although burbot and lake trout occupied similar mean daily depths (16.2m and 13.4m, respectively), and water temperatures (5.4°C and 6.9°C, respectively), they were spatially segregated. Burbot were closely associated with the lake bottom on steep drop-offs between the offshore and nearshore zone with moderate substrate complexity, whereas lake trout were located over deep offshore basins and suspended above the lake bottom. Northern pike occupied shallow depths (5.3m) and warmer water (16.5°C) within the nearshore region and were closely associated with bottom substrate of highest complexity. Some significant overlap among spatial home ranges and broad habitat niches indicated that these species interact. However, dietary niches did not significantly overlap at either the core or broad levels, suggesting that species were utilizing spatially diverse food sources. Our results highlight the importance of including depth and space when quantifying resource partitioning among fishes and provide insight into the mechanisms that promote piscivore co-occurrence in northern lakes

Cytokine-Neuroantigen Fusion Proteins as a New Class of Tolerogenic, Therapeutic Vaccines for Treatment of Inflammatory Demyelinating Disease in Rodent Models of Multiple Sclerosis

Myelin-specific induction of tolerance represents a promising means to modify the course of autoimmune inflammatory demyelinating diseases such as multiple sclerosis (MS). Our laboratory has focused on a novel preclinical strategy for the induction of tolerance to the major encephalitogenic epitopes of myelin that cause experimental autoimmune encephalomyelitis (EAE) in rats and mice. This novel approach is based on the use of cytokine-NAg (neuroantigen) fusion proteins comprised of the native cytokine fused either with or without a linker to a NAg domain. Several single-chain cytokine-NAg fusion proteins were tested including GMCSF-NAg, IFNbeta-NAg, NAgIL16, and IL2-NAg. These cytokine-NAg vaccines were tolerogenic, therapeutic vaccines that had tolerogenic activity when given as pre-treatments before encephalitogenic immunization and also were effective as therapeutic interventions during the effector phase of EAE. The rank order of inhibitory activity was as follows: GMCSF-NAg, IFNbeta-NAg > NAgIL16 > IL2-NAg > MCSF-NAg, IL4-NAg, IL-13-NAg, IL1RA-NAg, and NAg. Several cytokine-NAg fusion proteins exhibited antigen-targeting activity. High affinity binding of the cytokine domain to specific cytokine receptors on particular subsets of APC resulted in the concentrated uptake of the NAg domain by those APC which in turn facilitated the enhanced processing and presentation of the NAg domain on cell surface MHC class II glycoproteins. For most cytokine-NAg vaccines, the covalent linkage of the cytokine domain and NAg domain was required for inhibition of EAE, thereby indicating that antigenic targeting of the NAg domain to APC was also required in vivo for tolerogenic activity. Overall, these studies introduced a new concept of cytokine-NAg fusion proteins as a means to induce tolerance and to inhibit the effector phase of autoimmune disease. The approach has broad application for suppressive vaccination as a therapy for autoimmune diseases such as MS

DFT study of pressure induced phase transitions in LiYF4

An investigation of the pressure induced phase transition from the scheelite phase (I41/a, Z=4) to the fergusonite-like phase (I2/a, Z=4)/LaTaO(P21/c, Z=4) of LiYF4 is presented. Employing density functional theory (DFT) within the generalized gradient approximation, the internal degrees of freedom were relaxed for a pressure range of 0 GPa to 20 Gpa. The influence of pressure on the lattice vibration spectrum of the scheelite phase (I41/a, Z=4) was evaluated using the direct approach, i.e. using force constants calculated from atomic displacements. The transition volume is in good agreement with experiment, while the transition pressure is overestimated of 6 GPa. At 20 GPa, a P21/c structure with apentacoordinated lithium cation is found to be the most stable phase. This structure is compatible with a transition driven by a Bg zone-center soft optic mode linked to a soft-acoustic mode along the [11-1] direction as observed for the proper ferroelastic transition of BiVO4

Effects of pressure on the local atomic structure of CaWO4 and YLiF4: Mechanism of the scheelite-to-wolframite and scheelite-to-fergusonite transitions

The pressure response of the scheelite phase of CaWO4 (YLiF4) and the occurrence of the pressure induced scheelite-to-wolframite (M-fergusonite) transition are reviewed and discussed. It is shown that the change of the axial parameters under compression is related with the different pressure dependence of the W-O (Li-F) and Ca-O (Y-F) interatomic bonds. Phase transition mechanisms for both compounds are proposed. Furthermore, a systematic study of the phase transition in 16 different scheelite ABX4 compounds indicates that the transition pressure increases as the packing ratio of the anionic BX4 units around the A cations increases.Comment: 38 pages, 10 figures (Figure 5 corrected), accepted for publication in Journal of Solid State Chemistr

International Violence Against Women: U.S. Response and Policy Issues

This report addresses causes, prevalence, and consequences of violence against women. It provides examples of completed and ongoing U.S. activities that address VAW directly or include anti-VAW components. It outlines possible policy issues for the 112th Congress, including the scope and effectiveness of U.S. programs in addressing international VAW; further integrating anti-VAW programs into U.S. assistance and foreign policy mechanisms; U.S. funding for anti-VAW activities worldwide, particularly in light of the global financial crisis, economic recession, and subsequent calls to reduce the U.S. budget deficit; and strengthening U.S. government coordination of anti-VAW activities

International Violence Against Women: U.S. Response and Policy Issues

This report addresses causes, prevalence, and consequences of violence against women. It provides examples of completed and ongoing U.S. activities that address VAW directly or include anti-VAW components. It outlines possible policy considerations for the 111th Congress, including the scope and effectiveness of U.S. programs; further integrating anti-VAW programs into U.S. assistance and foreign policy mechanisms; and strengthening U.S. government coordination of anti-VAW activities

Fluorescent macrolide probes – synthesis and use in evaluation of bacterial resistance

This is the final version. Available on open access from the Royal Society of Chemistry via the DOI in this recordThe emerging crisis of antibiotic resistance requires a multi-pronged approach in order to avert the onset of a post-antibiotic age. Studies of antibiotic uptake and localisation in live cells may inform the design of improved drugs and help develop a better understanding of bacterial resistance and persistence. To facilitate this research, we have synthesised fluorescent derivatives of the macrolide antibiotic erythromycin. These analogues exhibit a similar spectrum of antibiotic activity to the parent drug and are capable of labelling both Gram-positive and -negative bacteria for microscopy. The probes localise intracellularly, with uptake in Gram-negative bacteria dependent on the level of efflux pump activity. A plate-based assay established to quantify bacterial labelling and localisation demonstrated that the probes were taken up by both susceptible and resistant bacteria. Significant intra-strain and -species differences were observed in these preliminary studies. In order to examine uptake in real-time, the probe was used in single-cell microfluidic microscopy, revealing previously unseen heterogeneity of uptake in populations of susceptible bacteria. These studies illustrate the potential of fluorescent macrolide probes to characterise and explore drug uptake and efflux in bacteria.Australian Postgraduate AwardInstitute for Molecular Biosciences Research Advancement AwardMedical Research Council (MRC)Gordon and Betty and Gordon Moore FoundationCampus France the Programme Hubert Curien FASIC 2018Wellcome TrustNHMR

Beyond screen time: a synergistic approach to a more comprehensive assessment of family media exposure during early childhood

Digital media availability has surged over the past decade. Because of a lack of comprehensive measurement tools, this rapid growth in access to digital media is accompanied by a scarcity of research examining the family media context and sociocognitive outcomes. There is also little cross-cultural research in families with young children. Modern media are mobile, interactive, and often short in duration, making them difficult to remember when caregivers respond to surveys about media use. The Comprehensive Assessment of Family Media Exposure (CAFE) Consortium has developed a novel tool to measure household media use through a web-based questionnaire, time-use diary, and passive-sensing app installed on family mobile devices. The goal of developing a comprehensive assessment of family media exposure was to take into account the contextual factors of media use and improve upon the limitations of existing self-report measures, while creating a consistent, scalable, and cost-effective tool. The CAFE tool captures the content and context of early media exposure and addresses the limitations of prior media measurement approaches. Preliminary data collected using this measure have been integrated into a shared visualization platform. In this perspective article, we take a tools-of-the-trade approach (Oakes, 2010) to describe four challenges associated with measuring household media exposure in families with young children: measuring attitudes and practices; capturing content and context; measuring short bursts of mobile device usage; and integrating data to capture the complexity of household media usage. We illustrate how each of these challenges can be addressed with preliminary data collected with the CAFE tool and visualized on our dashboard. We conclude with future directions including plans to test reliability, validity, and generalizability of these measures