Changes in volatile compounds and oil quality with the method of olive tree propagation and saline water irrigation

The main goal of this study was to investigate the effects of moderate saline water irrigation on the composition and quality of olive oil of the “Chemlali” olive cultivar in comparison to a control plot grown under rain-fed conditions from two methods of olive tree propagation (suckers and cuttings). The antioxidant compounds, oxidative stability and volatile compounds of virgin olive oil samples were determined and reported. The irrigation did not affect free acidity and peroxide value and specific ultraviolet absorbance (K232, K270). Whereas, fatty acid composition, oxidative stability, total phenol, total chlorophyll and carotenoid contents were affected by irrigation. Rain-fed virgin olive oils showed a statistically significant higher content of oleic and linoleic acids. However, olive oil samples obtained from fruit of irrigated trees from suckers had a higher content of (E)-2 hexenal (67.2%) and a higher content of total phenols (860 mg kg–1). Interestingly, more stable oil was obtained from moderate saline water irrigated trees from suckers compared to olives from cuttings

Evaluation des facteurs pronostiques pouvant influencer les resultats d’une septoplastie

Introduction :Une des principales étiologies de l’obstruction nasale est la déviation septale, dont le traitement chirurgical est la septoplastie. mais d’autres étiologies peuvent être à l’origine d’une obstruction nasale, notamment une hypertrophie des cornets, des végétations adénoïdes hypertrophiques, une polypose nasale, etc. Les critères de sélection sur lesquels se base un chirurgien pour décider de pratiquer une septoplastie, sont essentiellement basés sur l’évaluation clinique. Le but de nôtre travail est d’évaluer ces critères cliniques ainsi que les critères dermographiques pouvant influencer les résultats de la septoplastie.Patients et méthodes : On a évalué tous les patients qui ont eu une septoplastie dans les 2 à 10 dernières années. Les données cliniques ont été revues afin de préciser le siège de la déformation septale initiale, sa sévérité dictée par le chirurgien et les résultats fonctionnels de la septoplastie.Résultats et : les patients ayant une déviation septale antérieure ont rapporté le plus d’amélioration après septoplastie. Toutefois il ressort de notre étude qu’une sélection des patients basée uniquement sur l’évaluation clinique par le chirurgien de l’importance de la déviation septale est à l’origine d’un taux important d’insatisfaction des patientsObjective : a common etiology of nasal obstruction is deviation of the nasal septum, for witch septoplasty is the definitive treatment. But nasal obstruction can be caused by other conditions, such as turbinate hypertrophy, adenoid hypertrophy, and nasal polyposis. The surgeons’ selection criteria for septoplasty largely rely on clinical judgment alone. The aim of our study was to evaluate if this clinical criteria and the demographics ones could influence the results of septoplasty.Patients and methods :We evaluate all patients who underwent septoplasty in the past 2 to 10 years. Clinical files were reviewed to establish the initial type of septal deformity, its severity dictated by the surgeon and the functional results of septoplasty.Results and Conclusion : Subjects with anterior septal deformities were shown to benefit the most from septoplasty. However, selection of patients based on clinical evaluation alone does carry a considerable risk of patient dissatisfaction with end results

Carcinomes nasopharynges localement avances

Les carcinomes nasopharyngés représentent une entité spécifique différente des cancers de la tête et du cou. L’incidence est plus élevée en Asie du Sud-Est et en Afrique du Nord. Le pronostic reste sombre pour les stades localement avancés (IIB—IVB), plus d’un tiers des cas présenteront une récidive locale et/ou métastatique, la survie globale à cinq ans tous stades confondus est estimée à 50—70 %. L’objectif de ce travail est de préciser les aspects cliniques, diagnostiques, thérapeutiques et pronostiques chez 100 malades porteur de carcinome nasopharyngé localement avancé traités à l’Institut Salah Azaiz (ISA) et de préciser l’impact de la chimiothérapie neoadjuvante (CNA) ainsi que les séquelles thérapeutiques à court et à long terme.Mots clés : carcinome nasopharyngé - chimiothérapie - radiothérapieNasopharyngeal carcinoma represents a specific entity different from cancers of head and neck. The incidence is highest in South- East Asia and North Africa. The prognosis remains poor for locally advanced stages (IIB -IVB), more than one third of cases presented locally recurrent and / or metastatic disease, the overall five-year survival for all stages is estimated at 50-70%. The objective of this study is to clarify the impact of neoadjuvant chemotherapy on long-term survival among 100 patients treated in Institut of Salah Azaiz by neo adjuvant chemotherapy followed by locoregional radiotherapy for locally advanced nasopharyngeal carcinoma, and identify prognostic factors and clinical long term effect.Key words: nasopharyngeal carcinoma – chemotherapy - radiotherap

Facteurs predictifs d’atteinte ganglionnaire centrale dans les cancers differencies de la thyroïde. Analyses univariée et multivariée

Les cancers papillaires et vésiculaires de la thyroïde sont les cancers endocriniens les plus fréquents. L’envahissement ganglionnaire semble peu influencer la survie globale, mais majore les risques de récidive locorégionale et de métastases à distance. Cet envahissement est une complication fréquente des cancers papillaires de la thyroïde, moins rapporté dans les cancers vésiculaires. il implique un évidement ganglionnaire qui n’est pas sans risques. Pour déterminer les moyens de limiter les curages ganglionnaires, nous avons tenté de déterminer les critères per opératoires prédictifs de métastase ganglionnaire centrale et ainsi identifier les patients qui doivent bénéficier de cette procédure. Notre étude est une étude rétrospective portant sur 71 patients (49 femmes et 22 hommes) traités entre 2000 et 2011d’un cancer différencié de la thyroïde de type papillaire ou vésiculaire. Après analyse des critères épidémiologiques, cliniques et anatomopathologiques, nous avons trouvé une association significative entre l’envahissement extra capsulaire, l’envahissement ganglionnaire latéral, la bilatéralité et l’envahissement ganglionnaire central. un évidemment ganglionnaire central prophylactique doit donc être particulièrement considéré chez ces patients.Mots clés : carcinome thyroïdien, évidement ganglionnaire, métastase ganglionnaire.Papillary and follicular thyroid carcinomas are the most common form of endocrine carcinomas. Lymph node involvement seems to be a low risk factor for death, but it increases the risk for loco-regional recurrences and distant metastasis. Lymph node involvement is a common complication of papillary thyroid carcinoma, less reported in vesicular carcinoma. il involves node dissection and its resulting morbidity. To determine means of limiting lymph node dissections, we attempted to determine intra-operative criteria predictive of node metastasis and soidentify the patients likely to benefit from this procedure. Our study is a retrospective study of 71 patients (49 women and 22 men) treated between 2000 and 2011 from differentiated thyroid cancer (papillary or follicular).After analyses of the demographic, clinical and anatomopathological factors, we found a significant association among extra capsular invasion, lateral lymphnode metastasis, bilaterality, and central compartment lymph node metastasis. A prophylactic neck dissection of the central compartment should be considered particularly in these patients.Keyswords : thyroid carcinoma, lymph node dissection, lymph node metastases

Carcinome hybride de la fosse nasale

Hybrid carcinoma is a rare neoplasm, accounting for less than 0.1% of all registered tumors in salivary glands. Up to now, only one case of hybrid carcinoma of the nasal cavity has been described. In this report, we describe a case of hybrid carcinoma composed of epithelial-myoepithelial carcinoma with an adenoid cystic carcinoma component occurring in the nasal cavity in a 56-year-old woman. Caldwell-Luc means resection was performedand the patient revisited because of the tumor recurrence within two years of evolution. A second surgery was accomplished by means of Red Denker and a adjuvant radiation therapy is envisaged. We have not enough detachmentto speak about actual evolution. It is in our knowledge the second case of hybrid tumor of the nasal cavity described in the literature. Hybrid carcinoma of the nasal cavity is possible although rare. Therefore recognition of other component that is more aggressive and has a worse prognosis has therapeutic and prognostic ramifications.Keywords: Carcinoma; hybrid; tumors of nasal cavity

Osteomyelite atypique ou centrale de la base du crane d’origine sinusienne

Introduction : L’ostéomyélitede la base du crâne esttypiquement secondaire à une otite externe nécrosante chez des patients âgés, diabétiques. Elle atteint l’os temporal et est habituellement due au pseudomonasaeruginosa. Dans sa forme atypique, l’ostéomyélite atteint les os sphénoïdal ou occipital sans otite externe associéeet est beaucoup moins fréquente. Le but de cette étude est d’analyser les caractéristiques cliniques et de déterminer les modalités thérapeutiques de l’ostéomyélite nonotologique de la base du crâne.Méthodes : Nous avons revu rétrospectivement deux casd’ostéomyélite atypique de la base du crâne.Résultats : Les deux patients se sont présentés dans un tableau d’altération de l’état général, une asthénie, des céphalées et de la fièvre. Les signes rhinologiques étaient discrets. Aucun des deux patients n’avait de déficit neurologique. L’imagerie avait montré une destruction osseuse, la biologie a objectivé un syndrome infectieux et une biopsie osseuse trans sphénoïdale a confirmé le diagnostic d’ostéomyélite. Un traitement antibiotique prolongé a été instauré et les deux patients ont été guéris sans récidive moyennant un recul de 12 mois.Conclusion : l’atteinte ostéomyélitique centrale de la base du crâne est une affection rare dont la prise en charge passe par un prélèvement osseux précoce et un traitement approprié afin de prévenir ou limiter d’autres complications telles qu’une extension endocrânienne, un empyème, ou la mort.Mots Clés: Ostéomyélite; Base du crâne; sphenoïdite; IRMIntroduction : Skull base osteomyelitis typically arises as a complication of ear infection in older diabetic patients, involves the temporal bone, and has Pseudomonas aeruginosaas the usual pathogen. Atypical skull base osteomyelitis arising from the sphenoid or occipital bones without associated external otitis occurs much less frequently. The purpose of this study was to review the clinical featuresand determine efficacy of treatment for nonotologic osteomyelitis of the skull base.Methods : We retrospectively reviewed two cases of central or atypical skull base osteomyelitis.Results : The two patients presented with asthenia, headache, and fever. No patient presented with neurologic deficits. Contrary to malignant otitis externa, our cases were not preceded by immediate external infections and had normal external ear examinations. One patient had an underlying immunocompromising condition. Imaging demonstrated bone destruction, subsequent microbiological analysis diagnosed infection and a biopsy proved diagnosis of osteomyelitis, a prolonged antibiotic treatment was instored. The two patients were cured with no recurrence of skull base infection over 12-month follow-up period.Conclusion : Central skull base osteomyelitis is a rare disease whose treatment requires an early bone biopsy and appropriate treatment to prevent or limit other complications such as intracranial extension, empyema, or dead.Key Words : Osteomyelitis; Skull base; sphenoïditis; MR

Gestational diabetes mellitus in Cameroon: prevalence, risk factors and screening strategies

Copyright \ua9 2024 Sobngwi, Sobngwi-Tambekou, Katte, Echouffo-Tcheugui, Balti, Kengne, Fezeu, Ditah, Tchatchoua, Dehayem, Unwin, Rankin, Mbanya and Bell.Background: The burden of gestational diabetes (GDM) and the optimal screening strategies in African populations are yet to be determined. We assessed the prevalence of GDM and the performance of various screening tests in a Cameroonian population. Methods: We carried out a cross-sectional study involving the screening of 983 women at 24-28 weeks of pregnancy for GDM using serial tests, including fasting plasma (FPG), random blood glucose (RBG), a 1-hour 50g glucose challenge test (GCT), and standard 2-hour oral glucose tolerance test (OGTT). GDM was defined using the World Health Organization (WHO 1999), International Association of Diabetes and Pregnancy Special Group (IADPSG 2010), and National Institute for Health Care Excellence (NICE 2015) criteria. GDM correlates were assessed using logistic regressions, and c-statistics were used to assess the performance of screening strategies. Findings: GDM prevalence was 5\ub79%, 17\ub77%, and 11\ub70% using WHO, IADPSG, and NICE criteria, respectively. Previous stillbirth [odds ratio: 3\ub714, 95%CI: 1\ub727-7\ub776)] was the main correlate of GDM. The optimal cut-points to diagnose WHO-defined GDM were 5\ub79 mmol/L for RPG (c-statistic 0\ub762) and 7\ub71 mmol/L for 1-hour 50g GCT (c-statistic 0\ub776). The same cut-off value for RPG was applicable for IADPSG-diagnosed GDM while the threshold was 6\ub75 mmol/L (c-statistic 0\ub761) for NICE-diagnosed GDM. The optimal cut-off of 1-hour 50g GCT was similar for IADPSG and NICE-diagnosed GDM. WHO-defined GDM was always confirmed by another diagnosis strategy while IADPSG and GCT independently identified at least 66\ub79 and 41\ub70% of the cases. Interpretation: GDM is common among Cameroonian women. Effective detection of GDM in under-resourced settings may require simpler algorithms including the initial use of FPG, which could substantially increase screening yield

A novel LIPS assay for insulin autoantibodies

Insulin autoantibodies (IAA) are often the first marker of autoimmunity detected in children in the preclinical phase of type 1 diabetes (T1D). Currently, the vast majority of laboratories adopt the radiobinding micro-assay (RBA) for measuring IAA. Our aim was to replace RBA with a novel non-radioactive IAA Luciferase Immuno Precipitation System (LIPS) assay with improved performance. We developed (pro)insulin antigens with alternative placements of a NanoLuc (TM) luciferase reporter (NLuc). Performance in LIPS was evaluated by testing sera from new onset T1D (n = 80), blood donors (n = 123), schoolchildren (n = 186), first-degree relatives (FDRs) from the Bart's Oxford family study (n = 53) and from the Belgian Diabetes Registry (n = 136), coded sera from the Islet Autoantibody Standardization Program (IASP) (T1D n = 50, blood donors n = 90). IAA LIPS based on B chain-NLuc proinsulin or B chain-NLuc insulin, in which NLuc was fused at the C-terminus of the insulin B chain, required only 2 mu L of serum and a short incubation time, showed high concordance with RBA (Spearman r = 0.866 and 0.833, respectively), high assay performance (B chain-NLuc proinsulin ROC-AUC = 0.894 and B chain-NLuc insulin ROC-AUC = 0.916), and an adjusted sensitivity at 95% specificity ranking on par with the best assays submitted to the two most recent IASP workshops. In FDRs, the IAA LIPS showed improved discrimination of progressors to T1D compared to RBA. We established a novel high-performance non-radioactive IAA LIPS that might replace the current gold standard RBA and find wide application in the study of the IAA response in T1D