Anévrisme Intracrânien Rompu Et Infection Covid-19 : A Propos D’un Cas Et Revus De La Littérature

L’infection au SRAS-CoV-2 entraine des lésions vasculaires endothéliale au niveau cérébral. L’association de l’infection avec la rupture anévrysmale intracrânienne soulève la question d’une éventuelle relation de causalité. D’où l’intérêt de notre cas. Il s’agit d’une femme de 50 ans, hypertendu connue et ménopausé, admis pour une céphalée brutale avec perte de conscience bref, dans un contexte subfébrile et d’une dyspnée hypoxemiante. Elle a présenté un état de somnolence, un syndrome méningé et un syndrome infectieux clinique et biologique. Le scanner a retrouvé une hémorragie méningée Fischer 3 sur rupture anévrysmale localisé au niveau de l’artère communicante antérieure

Mélanome Malin Métastatique Spinal : A Propos D’un Cas Et Revus De La Littérature

Le mélanome malin métastatique de la colonne vertébrale sans lésion primaire connue est rare. On décrit ici le cas d’un jeune homme de 22 ans qui avait été admis pour une lombosciatalgie déficitaire intense, altération de l’état général et dysurie évoluant depuis 11 mois mais avec aggravation depuis 05 mois. Le scanner thoraco-lombo-pelvien avait objectivé des lésions ostéolytiques lombosacrées avec une compression du fourreau durale en L5-S1, et des micronodules pulmonaires. La laminectomie décompressive au niveau de L5 avec biopsie a été réalisée. L’examen anatomo-pathologique confirmait le mélanome malin. Aucune lésion suspecte de la peau et des muqueuses n’avait été retrouvée

Genetic diversity of hepatitis B virus (HBV) in Madagascar

Hepatitis B virus (HBV) is a DNA virus belonging to Hepadnaviridae family. Chronic infection with HBV is one major risk factor of hepatic disease. In Madagascar, former studies classified the country as part of high endemic area, as HBV prevalence can reach 23% in general population. However, this prevalence differs largely between urban and rural areas and is estimated to be respectively 5% and 26%. The aims of the present study were to describe the genetic diversity of HBV strains from different regions of Madagascar, and to describe the viral gene flow throughout the country by using phylogenetic analysis. This is the first large-scale molecular and phylogenetic study analyzing HBV sequences from 28 different Malagasy areas, never sampled in the past. In this study, the most prevalent genotype/sub-genotypes was E. Migration analysis showed a gene flow from zone 3 (rural) to zone 2 (suburban) and a greater gene flow from the middle part of Madagascar to the north than to the south. It is important to study the HBV infections in Madagascar and to monitor the potential spread of this viral strain inside this country

Pain in platin-induced neuropathies: A systematic review and meta-analysis

INTRODUCTION: Platin-induced peripheral neuropathy (PIPN) is a common cause of PN in cancer patients. The aim of this paper is to systematically review the current literature regarding PIPN, with a particular focus on epidemiological and clinical characteristics of painful PIPN, and to discuss relevant management strategies. METHODS: A systematic computer-based literature search was conducted on the PubMed database. RESULTS: This search strategy resulted in the identification of 353 articles. After the eligibility assessment, 282 articles were excluded. An additional 24 papers were identified by scanning the reference lists. In total, 95 papers met the inclusion criteria and were used for this review. The prevalence of neuropathic symptoms due to acute toxicity of oxaliplatin was estimated at 84.6%, whereas PN established after chemotherapy with platins was estimated at 74.9%. Specifically regarding pain, the reported prevalence of pain due to acute toxicity of oxaliplatin was estimated at 55.6%, whereas the reported prevalence of chronic peripheral neuropathic pain in PIPN was estimated at 49.2%. CONCLUSION: Peripheral neuropathy is a common complication in patients receiving platins and can be particularly painful. There is significant heterogeneity among studies regarding the method for diagnosing peripheral neuropathy. Nerve conduction studies are the gold standard and should be performed in patients receiving platins and complaining of neuropathic symptoms post-treatment

Les gisements de corindons gemmes de Madagascar [The gem corundum deposits of Madagascar]

No abstract available

Les gisements de corindons gemmes de Madagascar

International audienc

Gem corundum deposits in Madagascar: a review

International audienc

Oxygen isotope systematics of gem corundum deposits in Madagascar: relevance for their geological origin

The oxygen isotopic composition of gem corundum was measured from 22 deposits and occurrences in Madagascar to provide a gemstone geological identification and characterization. Primary corundum deposits in Madagascar are hosted in magmatic (syenite and alkali basalt) and metamorphic rocks (gneiss, cordieritite, mafic and ultramafic rocks, marble, and calc-silicate rocks). In both domains the circulation of fluids, especially along shear zones for metamorphic deposits, provoked in situ transformation of the corundum host rocks with the formation of metasomatites such as phlogopite, sakenite, and corundumite. Secondary deposits (placers) are the most important economically and are contained in detrital basins and karsts. The oxygen isotopic ratios (18O/16O) of ruby and sapphire from primary deposits are a good indicator of their geological origin and reveal a wide range of δ18O (Vienna Standard Mean Ocean Water) between 1.3 and 15.6‰. Metamorphic rubies are defined by two groups of δ18O values in the range of 1.7 to 2.9‰ (cordieritite) and 3.8 to 6.1‰ (amphibolite). “Magmatic” rubies from pyroxenitic xenoliths contained in the alkali basalt of Soamiakatra have δ18O values ranging between 1.3 and 4.7‰. Sapphires are classified into two main groups with δ18O in the range of 4.7 to 9.0‰ (pyroxenite and feldspathic gneiss) and 10.7 to 15.6‰ (skarn in marble from Andranondambo). The δ18O values for gem corundum from secondary deposits have a wide spread between −0.3 and 16.5‰. The ruby and sapphire found in placers linked to alkali basalt environments in the northern and central regions of Madagascar have consistent δ18O values between 3.5 and 6.9‰. Ruby from the placers of Vatomandry and Andilamena has δ18O values of 5.9‰, and between 0.5 and 4.0‰, respectively. The placers of the Ilakaka area are characterized by a huge variety of colored sapphires and rubies, with δ18O values between −0.3 and 16.5‰, and their origin is debated. A comparison with oxygen isotope data obtained on gem corundum from Eastern Africa, India, and Sri Lanka is presented. Giant placer deposits from Sri Lanka, Madagascar, and Tanzania have a large variety of colored sapphires and rubies with a large variation in δ18O due to mingling of corundum of different origin: mafic and ultramafic rocks for ruby, desilicated pegmatites for blue sapphire, syenite for yellow, green, and blue sapphire, and skarn in marbles for blue sapphire