Self-Determination in Hong Kong: A New Challenge to an Old Doctrine

This Comment examines the upcoming transition of Hong Kong as a special administrative region of the People\u27s Republic of China (PRC) in 1997. The author argues that, in addition to the economic freedoms that will be preserved in Hong Kong, the people of Hong Kong should be guaranteed the right of self-determination in order to increase the level of confidence with which the people of Hong Kong view this transition. The author examines the history of the sovereign claims to Hong Kong and the substance of the transition agreement between Great Britain and the PRC. The author concludes that the right of self-determination should be invoked on behalf of the people of Hong Kong to allow them to make a free and informed choice for the future

A conserved and essential basic region mediates tRNA binding to the Elp1 subunit of the <em>Saccharomyces cerevisiae</em> Elongator complex

Elongator is a conserved, multi-protein complex discovered in Saccharomyces cerevisiae, loss of which confers a range of pleiotropic phenotypes. Elongator in higher eukaryotes is required for normal growth and development and a mutation in the largest subunit of human Elongator (Elp1) causes familial dysautonomia, a severe recessive neuropathy. Elongator promotes addition of mcm(5) and ncm(5) modifications to uridine in the tRNA anticodon ‘wobble’ position in both yeast and higher eukaryotes. Since these modifications are required for the tRNAs to function efficiently, a translation defect caused by hypomodified tRNAs may therefore underlie the variety of phenotypes associated with Elongator dysfunction. The Elp1 carboxy-terminal domain contains a highly conserved arginine/lysine-rich region that resembles a nuclear localization sequence (NLS). Using alanine substitution mutagenesis, we show that this region is essential for Elongator's function in tRNA wobble uridine modification. However, rather than acting to determine the nucleo-cytoplasmic distribution of Elongator, we find that the basic region plays a critical role in a novel interaction between tRNA and the Elp1 carboxy-terminal domain. Thus the conserved basic region in Elp1 may be essential for tRNA wobble uridine modification by acting as tRNA binding motif

Cold Power Tests of the sc 325 MHz CH-Cavity

At the Institute for Applied Physics (IAP), Frankfurt University, a superconducting 325 MHz CH-Cavity has been designed, built and first tests have successfully been performed. The cavity is determined for a 11.4 AMeV, 10 mA ion beam at the GSI UNILAC. Consisting of 7 gaps this resonator is envisaged to deliver a gradient of 5 MV/m. Novel features of this structure are a compact design, low peak fields, improved surface processing and power coupling. Furthermore a tuner system based on bellow tuners driven by a stepping motor and a piezo actuator and attached inside the resonator will control the frequency. In this contribution measurements executed at 4 K and 2 K at the cryo lab in Frankfurt will be presented

The Toxoplasma gondii active serine hydrolase 4 regulates parasite division and intravacuolar parasite architecture

ABSTRACT Hydrolase are enzymes that regulate diverse biological processes, including posttranslational protein modifications. Recent work identified four active serine hydrolases (ASHs) in Toxoplasma gondii as candidate depalmitoylases. However, only TgPPT1 (ASH1) has been confirmed to remove palmitate from proteins. ASH4 (TgME49_264290) was reported to be refractory to genetic disruption. We demonstrate that recombinant ASH4 is an esterase that processes short acyl esters but not palmitoyl thioesters. Genetic disruption of ASH4 causes defects in cell division and premature scission of parasites from residual bodies. These defects lead to the presence of vacuoles with a disordered intravacuolar architecture, with parasites arranged in pairs around multiple residual bodies. Importantly, we found that the deletion of ASH4 correlates with a defect in radial dispersion from host cells after egress. This defect in dispersion of parasites is a general phenomenon that is observed for disordered vacuoles that occur at low frequency in wild-type parasites, suggesting a possible general link between intravacuolar organization and dispersion after egress. IMPORTANCE This work defines the function of an enzyme in the obligate intracellular parasite Toxoplasma gondii. We show that this previously uncharacterized enzyme is critical for aspects of cellular division by the parasite and that loss of this enzyme leads to parasites with cell division defects and which also are disorganized inside their vacuoles. This leads to defects in the ability of the parasite to disseminate from the site of an infection and may have a significant impact on the parasite's overall infectivity of a host organism

On a theorem of Kang and Liu on factorised groups

[EN] Kang and Liu ['On supersolvability of factorized finite groups', Bull. Math. Sci. 3 (2013), 205-210] investigate the structure of finite groups that are products of two supersoluble groups. The goal of this note is to give a correct proof of their main theorem.The first author was supported by the grant MTM2014-54707-C3-1-P from the Ministerio de Economia y Competitividad, Spain, and FEDER, European Union, and a project of Natural Science Foundation of Guangdong Province (No. 2015A030313791).Ballester-Bolinches, A.; Pedraza Aguilera, MC. (2018). On a theorem of Kang and Liu on factorised groups. Bulletin of the Australian Mathematical Society. 97(1):54-56. https://doi.org/10.1017/S0004972717000363S5456971Ezquerro, L. M., & Soler-Escrivà, X. (2003). On MutuallyM-Permutable Products of Finite Groups. Communications in Algebra, 31(4), 1949-1960. doi:10.1081/agb-120018515Kang, P., & Liu, Q. (2013). On supersolvability of fatorized finite groups. Bulletin of Mathematical Sciences, 3(2), 205-210. doi:10.1007/s13373-013-0032-4Ballester-Bolinches, A., Esteban-Romero, R., & Asaad, M. (2010). Products of Finite Groups. de Gruyter Expositions in Mathematics. doi:10.1515/9783110220612Ballester-Bolinches, A., Cossey, J., & Pedraza-Aguilera, M. C. (2001). ON PRODUCTS OF FINITE SUPERSOLUBLE GROUPS. Communications in Algebra, 29(7), 3145-3152. doi:10.1081/agb-501

Some solubility criteria in factorised groups

This paper has been published in Bulletin of the Australian Mathematical Society, 86(1):22-28 (2012). Copyright 2012 by Australian Mathematical Publishing Association Inc and Cambridge University Press Journals. The final publication is available at http://journals.cambridge.org/abstract_S0004972711003418In this paper, solubility of groups factorised as a product of two subgroups which are connected by certain permutability properties is studied.The research of the second and the third authors has been supported by the grant MTM2010-19938-C03-01 from the Ministerio de Ciencia e Innovacion (Spanish government).http://dx.doi.org/10.1017/S0004972711003418Asaad, M.; Ballester Bolinches, A.; Esteban Romero, R. (2012). Some solubility criteria in factorised groups. Bulletin of the Australian Mathematical Society. (86). doi:10.1017/S0004972711003418S8