Detecting primordial gravitational waves with circular polarization of the redshifted 21 cm line: II. Forecasts

In the first paper of this series, we showed that the CMB quadrupole at high redshifts results in a small circular polarization of the emitted 21 cm radiation. In this paper we forecast the sensitivity of future radio experiments to measure the CMB quadrupole during the era of first cosmic light ($z\sim 20$). The tomographic measurement of 21 cm circular polarization allows us to construct a 3D remote quadrupole field. Measuring the $B$-mode component of this remote quadrupole field can be used to put bounds on the tensor-to-scalar ratio $r$. We make Fisher forecasts for a future Fast Fourier Transform Telescope (FFTT), consisting of an array of dipole antennas in a compact grid configuration, as a function of array size and observation time. We find that a FFTT with a side length of 100 km can achieve $\sigma(r)\sim 4\times 10^{-3}$ after ten years of observation and with a sky coverage $f_{\mathrm{sky}}\sim 0.7$. The forecasts are dependent on the evolution of the Lyman-$\alpha$ flux in the pre-reionization era, that remains observationally unconstrained. Finally, we calculate the typical order of magnitudes for circular polarization foregrounds and comment on their mitigation strategies. We conclude that detection of primordial gravitational waves with 21 cm observations is in principle possible, so long as the primordial magnetic field amplitude is small, but would require a very futuristic experiment with corresponding advances in calibration and foreground suppression techniques.Comment: 19 pages, matches PRD accepted versio

Detecting primordial gravitational waves with circular polarization of the redshifted 21 cm line: I. Formalism

We propose a new method to measure the tensor-to-scalar ratio $r$ using the circular polarization of the 21 cm radiation from the pre-reionization epoch. Our method relies on the splitting of the $F = 1$ hyperfine level of neutral hydrogen due to the quadrupole moment of the CMB. We show that unlike the Zeeman effect, where $M_{F}=\pm 1$ have opposite energy shifts, the CMB quadrupole shifts $M_{F}=\pm 1$ together relative to $M_{F}= 0$. This splitting leads to a small circular polarization of the emitted 21 cm radiation. In this paper (Paper I in a series on this effect), we present calculations on the microphysics behind this effect, accounting for all processes that affect the hyperfine transition. We conclude with an analytic formula for the circular polarization from the Dark Ages as a function of pre-reionization parameters and the value of the remote quadrupole of the CMB. We also calculate the splitting of the $F = 1$ hyperfine level due to other anisotropic radiation sources and show that they are not dominant. In a companion paper (Paper II) we make forecasts for measuring the tensor-to-scalar ratio $r$ using future radio arrays.Comment: 20 pages, significantly expanded description of the effect; matches PRD accepted versio

Elastic anisotropy measures for heterogeneous materials

Heterogeneous materials exhibit anisotropy to varying extent that is influenced by factors such as individual phase properties and microstructural configuration. A review of the existing anisotropy measures proposed in the context of single crystals reveal that they do not account for the material and microstructural descriptors influencing the extent of anisotropy in heterogeneous materials. To overcome this limitation, existing anisotropy indices have been re-interpreted by considering the effective elastic properties of heterogeneous materials obtained by appropriate effective property estimates. Anisotropy quantification has been demonstrated considering two phase composite materials highlighting the role of constituent volume fractions, secondary phase shape and elastic contrast in influencing the extent of anisotropy. The proposed approach can be generalized to consider other physical fields, multiphysics and non-linearity

New probe of magnetic fields in the prereionization epoch. I. Formalism

We propose a method of measuring extremely weak magnetic fields in the intergalactic medium prior to and during the epoch of cosmic reionization. The method utilizes the Larmor precession of spin-polarized neutral hydrogen in the triplet state of the hyperfine transition. This precession leads to a systematic change in the brightness temperature fluctuations of the 21-cm line from the high-redshift universe, and thus the statistics of these fluctuations encode information about the magnetic field the atoms are immersed in. The method is most suited to probing fields that are coherent on large scales; in this paper, we consider a homogenous magnetic field over the scale of the 21-cm fluctuations. Due to the long lifetime of the triplet state of the 21-cm transition, this technique is naturally sensitive to extremely weak field strengths, of order $10^{-19}$ G at a reference redshift of $\sim 20$ (or $10^{-21}$ G if scaled to the present day). Therefore, this might open up the possibility of probing primordial magnetic fields just prior to reionization. If the magnetic fields are much stronger, it is still possible to use this method to infer their direction, and place a lower limit on their strength. In this paper (Paper I in a series on this effect), we perform detailed calculations of the microphysics behind this effect, and take into account all the processes that affect the hyperfine transition, including radiative decays, collisions, and optical pumping by Lyman-$\alpha$ photons. We conclude with an analytic formula for the brightness temperature of linear-regime fluctuations in the presence of a magnetic field, and discuss its limiting behavior for weak and strong fields.Comment: 26 pages, 4 figures, updated to match published versio

Remodeling of Fibrous Extracellular Matrices by Contractile Cells: Predictions from Discrete Fiber Network Simulations

Contractile forces exerted on the surrounding extracellular matrix (ECM) lead to the alignment and stretching of constituent fibers within the vicinity of cells. As a consequence, the matrix reorganizes to form thick bundles of aligned fibers that enable force transmission over distances larger than the size of the cells. Contractile force-mediated remodeling of ECM fibers has bearing on a number of physiologic and pathophysiologic phenomena. In this work, we present a computational model to capture cell-mediated remodeling within fibrous matrices using finite element based discrete fiber network simulations. The model is shown to accurately capture collagen alignment, heterogeneous deformations, and long-range force transmission observed experimentally. The zone of mechanical influence surrounding a single contractile cell and the interaction between two cells are predicted from the strain-induced alignment of fibers. Through parametric studies, the effect of cell contractility and cell shape anisotropy on matrix remodeling and force transmission are quantified and summarized in a phase diagram. For highly contractile and elongated cells, we find a sensing distance that is ten times the cell size, in agreement with experimental observations.Comment: Accepted for publication in the Biophysical Journa

Detection of DNA and Poly-L-Lysine using CVD Graphene-channel FET Biosensors

A graphene channel field-effect biosensor is demonstrated for detecting the binding of double-stranded DNA and poly-l-lysine. Sensors consist of CVD graphene transferred using a clean, etchant-free transfer method. The presence of DNA and poly-l-lysine are detected by the conductance change of the graphene transistor. A readily measured shift in the Dirac Voltage (the voltage at which the graphenes resistance peaks) is observed after the graphene channel is exposed to solutions containing DNA or poly-l-lysine. The Dirac voltage shift is attributed to the binding/unbinding of charged molecules on the graphene surface. The polarity of the response changes to positive direction with poly-l-lysine and negative direction with DNA. This response results in detection limits of 8 pM for 48.5 kbp DNA and 11 pM for poly-l-lysine. The biosensors are easy to fabricate, reusable and are promising as sensors of a wide variety of charged biomolecule

Low-power photothermal self-oscillation of bimetallic nanowires

We investigate the nonlinear mechanics of a bimetallic, optically absorbing SiN-Nb nanowire in the presence of incident laser light and a reflecting Si mirror. Situated in a standing wave of optical intensity and subject to photothermal forces, the nanowire undergoes self-induced oscillations at low incident light thresholds of $<1\, \rm{\mu W}$ due to engineered strong temperature-position ($T$-$z$) coupling. Along with inducing self-oscillation, laser light causes large changes to the mechanical resonant frequency $\omega_0$ and equilibrium position $z_0$ that cannot be neglected. We present experimental results and a theoretical model for the motion under laser illumination. In the model, we solve the governing nonlinear differential equations by perturbative means to show that self-oscillation amplitude is set by the competing effects of direct $T$-$z$ coupling and $2\omega_0$ parametric excitation due to $T$-$\omega_0$ coupling. We then study the linearized equations of motion to show that the optimal thermal time constant $\tau$ for photothermal feedback is $\tau \to \infty$ rather than the widely reported $\omega_0 \tau = 1$. Lastly, we demonstrate photothermal quality factor ($Q$) enhancement of driven motion as a means to counteract air damping. Understanding photothermal effects on micromechanical devices, as well as nonlinear aspects of optics-based motion detection, can enable new device applications as oscillators or other electronic elements with smaller device footprints and less stringent ambient vacuum requirements.Comment: New references adde

Efficient Dynamic Group Signature Scheme with Verifier Local Revocation and Time-Bound Keys using Lattices

Revocation is an important feature of group signature schemes. Verifier Local Revocation (VLR) is a popular revocation mechanism which involves only verifiers in the revocation process. In VLR, a revocation list is maintained to store the information about revoked users. The verification cost of VLR based schemes islinearly proportional to the size of recvocation list. In many applications, the size of revocation list grows with time, which makes the verification process expensive. In this paper, we propose a lattice based dynamic group signature using VLR and time bound keys to reduce the size of revocation list to speed up the verification process. In the proposed scheme, an expiration date is fixed for signing key of each group member, and verifiers can find out (at constantcost) if a signature is generated using an expired key. Hence revocation information of members who are revoked before signing key expiry date (premature revocation) are kept in revocation list, and other members are part of natural revocation. This leads to a significant saving on the revocation check by assuming natural revocation accounts for large fraction of the total revocation. This scheme also takes care of non-forgeability of signing key expiry date

Correlation and prediction of dynamic human isolated joint strength from lean body mass

A relationship between a person's lean body mass and the amount of maximum torque that can be produced with each isolated joint of the upper extremity was investigated. The maximum dynamic isolated joint torque (upper extremity) on 14 subjects was collected using a dynamometer multi-joint testing unit. These data were reduced to a table of coefficients of second degree polynomials, computed using a least squares regression method. All the coefficients were then organized into look-up tables, a compact and convenient storage/retrieval mechanism for the data set. Data from each joint, direction and velocity, were normalized with respect to that joint's average and merged into files (one for each curve for a particular joint). Regression was performed on each one of these files to derive a table of normalized population curve coefficients for each joint axis, direction, and velocity. In addition, a regression table which included all upper extremity joints was built which related average torque to lean body mass for an individual. These two tables are the basis of the regression model which allows the prediction of dynamic isolated joint torques from an individual's lean body mass

Proactively Investigating “Limits of use” with Medical Device Manufacturers – An Example Case: Robotic Surgery

AbstractThis paper presents an exploration of strategies undertaken by a consortium of clinical teams and manufacturers to proactively prepare and support use of new categories of medical devices. Potential avenues of exploration include leveraging other domains, such as the US Space program, providing innovative methods of training and research and development in known areas of concern such as systems integration. By a commitment to creating a safer system, we are committing to providing safer care to patients. We believe incorporating the ‘lessons learned’ from the largest possible set of real-world scenarios, into the design and use of medical devices, will accelerate success