Assessment of satisfaction in patients after hysterectomy by myomatous uterus

Objetivo: el objetivo de este estudio es evaluar los resultados, en cuanto a calidad de vida, de aquellas pacientes que han sido sometidas a una histerectomía por útero miomatoso. Material y métodos: se realiza una encuesta sobre calidad de vida a todas las pacientes sometidas a histerectomía con indicación de útero miomatoso, en un hospital de tercer nivel dentro de la red de hospitales del servicio de salud de la Comunidad de Madrid, en el año 2010. Resultados: Se identificaron un total de 152 pacientes a las que se les había realizado una histerectomía por útero miomatoso, de las cuales contestaron la encuesta un total de 112 (74%) pacientes. Cuando se les preguntó a las pacientes si había mejorado su calidad de vida tras la realización de la histerectomía, un 78’6% (88/112) respondió afirmativamente, un 17% (19/112) refirió tener la misma calidad de vida, y un 4’4% (5/112) respondió que su calidad de vida había empeorado tras la intervención. Conclusiones: las pacientes sometidas a una histerectomía por útero miomatoso presentan un alto grado de satisfacción tras la cirugía, comunicando en su mayoría una mejora en cuanto al dolor pélvico previo a la cirugía, y una mejor calidad de vida tras la intervenciónObjective: the objective of this study is to evaluate the results, in terms of quality of life of those patients who have undergone hysterectomy for fibroid uterus. Material and methods: we performed a survey on quality of life for all patients undergoing hysterectomy with uterine fibroid indication in a tertiary care hospital within the hospital network of the health service of the Community of Madrid, in the year 2010. Results: a total of 152 patients which had undergone a hysterectomy for uterine myoma, which answered the survey a total of 112 (74%) patients. When asked patients if they had improved their quality of life after performing a hysterectomy, a 78’6% (88/112) responded affirmatively, 17% (19/112) reported having the same quality of life, and 4.4% (5/112) responded that their quality of life had worsened after surgery. Conclusions: patients undergoing a hysterectomy for uterine fibroids have a high degree of satisfaction after the surgery, communicating mostly an improvement in pelvic pain prior to surgery, and improved quality of life after surger

Protandric Transcriptomes to Uncover Parts of the Crustacean Sex-Differentiation Puzzle

Hermaphrodite systems offer unique opportunities to study sexual differentiation, due to their high degree of sexual plasticity and to the fact that, unlike gonochoristic systems, the process is not confined to an early developmental stage. In protandric shrimp species, such as Hippolyte inermis and Pandalus platyceros, male differentiation is followed by transformation to femaleness during adulthood. The mechanisms controlling sexual differentiation have not been fully elucidated in crustaceans, but a key role has been attributed to the insulin-like hormone (IAG) produced by the androgenic gland (AG), a crustacean masculine endocrine organ. To uncover further transcriptomic toolkit elements affecting the sexual differentiation of H. inermis, we constructed eye and whole body RNA libraries of four representative stages during its protandric life cycle (immature, male, young female and mature female). The body libraries contained transcripts related to the reproductive system, among others, while the eye libraries contained transcripts related to the X-organ-sinus gland, a central endocrine complex that regulates crustacean reproduction. Binary pattern analysis, performed to mine for genes expressed differentially between the different life stages, yielded 19,605 and 6,175 transcripts with a specific expression pattern in the eye and body, respectively. Prominent sexually biased transcriptomic patterns were recorded for the IAG and vitellogenin genes, representing, respectively, a key factor within the masculine IAG-switch, and a precursor of the yolk protein, typical of feminine reproductive states. These patterns enabled the discovery of novel putative protein-coding transcripts exhibiting sexually biased expression in the H. inermis body and eye transcriptomes of males and females. Homologs to the above novel genes have been found in other decapod crustaceans, and a comparative study, using previously constructed transcriptomic libraries of another protandric shrimp, P. platyceros, showed similar sexually biased results, supporting the notion that such genes, mined from the H. inermis transcriptome, may be universal factors related to reproduction and sexual differentiation and their control in other crustaceans. This study thus demonstrates the potential of transcriptomic studies in protandric species to uncover unexplored layers of the complex crustacean sex-differentiation puzzle

Placenta percreta, experiencia en 20 años del Hospital Universitario La Paz, Madrid, España

La placenta percreta es una rara enfermedad placentaria, con una incidencia muy baja y un muy difícil diagnóstico prenatal. Se presentan tres casos clínicos de placenta percreta recogidos en nuestro centro en los últimos 20 años. Se realiza una exposición detallada de cada uno de ellos, atendiendo fundamentalmente a la secuencia de acontecimientos quirúrgicos que tienen lugar tras el diagnóstico de esta grave entidad. La dificultad en el diagnóstico prenatal, así como la imperiosidad de las medidas terapéuticas, convierten a la placenta percreta en una enfermedad con una elevada morbilidad y mortalidad materna. El tratamiento quirúrgico así como la prevención y el tratamiento de la hemorragia posparto son las armas fundamentales para controlar esta gravísima complicación obstétrica.<br>The placenta percreta is a rare placental disease with a very low incidence and prenatal diagnosis difficult. We present three cases of placenta percreta observed in our hospital over the past 20 years. We present a detailed discussion of each of them, fundamentally to the sequence of surgical events that occur after the diagnosis of this serious entity. The difficulty of prenatal diagnosis, as well as the urgent therapeutic measures, make the placenta percreta in a disease with high morbidity and mortality. The surgical treatment and the prevention of postpartum hemorrhage are essential weapons to control this serious obstetric complication

Preface: Recent advances in Crustacean Genomics

Este artículo consta de 4 páginas.This Special Issue on Crustacean Genomics arises from the TCS 2017 conference held in Barcelona, Spain, between 19 and 22 June, 2017. Applications of next generation sequencing have expanded rapidly over recent years, unveiling many new and exciting areas of genomic research. This includes novel insights into physiology, reproductive biology, response to environmental challenges, and their evolutionary history. Despite their importance, crustaceans still lack genomic resources compared with other widely-studied groups such as insects and vertebrates. The present volume integrates a collection of contributions from the speakers, and compiles the main results presented during the symposium. Following the structure of the Crustacean Genomics workshop, contributed papers have been arranged in two main blocks, a first set of studies focused on the use of transcriptomics to investigate crustacean physiology and reproduction while the second set focused on molecular systematics and evolutionary studies.Peer reviewe