1,588 research outputs found
Efficacy and Safety Comparison of Liraglutide, Glimepiride, and Placebo, All in Combination With Metformin, in Type 2 Diabetes: The LEAD (Liraglutide Effect and Action in Diabetes)-2 study
OBJECTIVE—The efficacy and safety of adding liraglutide (a glucagon-like peptide-1 receptor agonist) to metformin were compared with addition of placebo or glimepiride to metformin in subjects previously treated with oral antidiabetes (OAD) therapy
Do Genetic Markers of Inflammation Modify the Relationship between Periodontitis and Nonalcoholic Fatty Liver Disease? Findings from the SHIP Study
An association between periodontitis and nonalcoholic fatty liver disease (NAFLD) has been reported by experimental animal and epidemiologic studies. This study investigated whether circulating levels of serum C-reactive protein (CRP) and a weighted genetic CRP score representing markers of inflammatory burden modify the association between periodontitis and NAFLD. Data came from 2,481 participants of the Study of Health in Pomerania who attended baseline examination that occurred between 1997 and 2001. Periodontitis was defined as the percentage of sites (0%, 3 mg/L. Periodontitis was positively associated with higher prevalence odds of NAFLD, and this relationship was modified by serum CRP levels
Reference standardization and triglyceride interference of a new homogeneous HDL-cholesterol assay compared with a former chemical precipitation assay
A homogeneous HDL-c assay (HDL-H), which uses polyethylene glycol-modified
enzymes and sulfated alpha-cyclodextrin, was assessed for precision,
accuracy, and cholesterol and triglyceride interference. In addition, its
analytical performance was compared with that of a phosphotungstic acid
(PTA)/MgCl2 precipitation method (HDL-P). Within-run CVs were < or =
1.87%; total CVs were < or = 3.08%. Accuracy was evaluated in fresh
normotriglyceridemic sera using the Designated Comparison Method (HDL-H =
1.037 Designated Comparison Method + 4 mg/L; n = 63) and in moderately
hypertriglyceridemic sera by using the Reference Method (HDL-H = 1.068
Reference Method - 17 mg/L; n = 41). Mean biases were 4.5% and 2.2%,
respectively. In hypertriglyceridemic sera (n = 85), HDL-H concentrations
were increasingly positively biased with increasing triglyceride
concentrations. The method comparison between HDL-H and HDL-P yielded the
following equation: HDL-H = 1.037 HDL-P + 15 mg/L; n = 478. We conclude
that HDL-H amply meets the 1998 NCEP recommendations for total error; its
precision is superior compared with that of HDL-P, and its average bias
remains below +/-5% as long as triglyceride concentrations are < or = 10
g/L and in case of moderate hypercholesterolemia
Emerging role of insulin with incretin therapies for management of type 2 diabetes
Type 2 diabetes mellitus (T2DM) is a progressive disease warranting intensification of treatment, as beta-cell function declines over time. Current treatment algorithms recommend metformin as the first-line agent, while advocating the addition of either basal-bolus or premixed insulin as the final level of intervention. Incretin therapy, including incretin mimetics or enhancers, are the latest group of drugs available for treatment of T2DM. These agents act through the incretin axis, are currently recommended as add-on agents either as second-or third-line treatment, without concurrent use of insulin. Given the novel role of incretin therapy in terms of reducing postprandial hyperglycemia, and favorable effects on weight with reduced incidence of hypoglycemia, we explore alternative options for incretin therapy in T2DM management. Furthermore, as some evidence alludes to incretins potentially increasing betacell mass and altering disease progression, we propose introducing these agents earlier in the treatment algorithm. In addition, we suggest the concurrent use of incretins with insulin, given the favorable effects especially in relation to weight gain
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