Bir devrimci:Muammer Aksoy

Taha Toros Arşivi, Dosya No: 176-Muammer-Erol Akso

The effect of sulforaphane on oxidative stress and inflammation in rats with toxic hepatitis induced by acetaminophene

OBJECTIVE: The aim of the present study was to reveal the possible effect of sulforaphane on oxidative stress and inflammation in rats liver with toxic hepatitis induced by acetaminophene. BACKGROUND: Sulforaphane is a compound with high antioxidant properties. Acetaminophen, which is a para-aminophenol derivative, can lead to fatal hepatic necrosis with direct hepatotoxic effects at high doses. METHODS: Thirty six male Sprague-Dawley rats were randomly divided into four groups. Control group (n = 9) was fed with standard rat chow and water for 3 days. Group APAP (n = 9) received a single dose acetaminophen 1 g/kg by oral gavage in addition to standard chow and water. Group SFN (n = 9) received sulforaphane 500 mu g/kg by oral gavage in addition to standard chow and water for 3 days. Group APAP+SFN (n = 9) received sulforaphane 500 mu g/kg and a single dose acetaminophen 1 g/kg by oral gavage in addition to standard chow and water. Acetaminophen was administered three hours after SFN administration. RESULTS: Neopterin, MDA, AST, ALT and CRP levels of group APAP were significantly increased compared to control group. GSH level of group APAP was significantly lower than in the control group. CONCLUSION: Sulforaphane is a protective agent against acetaminophen-induced liver damage and it can be added in the treatment protocol (Tab. 1, Fig. 5, Ref. 51). Text in PDF www.elis.sk

Changes in mechanical and morphological properties of AISI 420 stainless steels welded with M42 steel wire Associated with weld cooling medium

Bu çalışmada, AISI 420 martenzitik paslanmaz çeliklere TIG kaynak yöntemiyle Argon gazı korumalı ortamda, 75 amper 45cm/dk kaynak ilerleme hızıyla kaynak dikişleri çekilmiştir. Bu amaç için Ø 50mm çapında ve 2, 3.5, 5 ve 6.5 mm kalınlıklarında disk şeklinde parçalar hazırlanmıştır. 50 mm boyunca kaynak dikişi oluşturulan bu parçaların kaynaktan hemen sonra farklı soğutma sıvılarına daldırılarak oda sıcaklığına kadar soğumaları sağlanmıştır. Deney numunelerinin sertlik ölçümü kaynak dikişinden esas metale doğru gerçekleştirilmiştir. Mikroyapı karakteristikleri ise optik mikroskop, taramalı elektron mikroskobu (SEM) vasıtasıyla incelenmiştir. Sonuç olarak, östenitik yapının yüksek soğuma hızından etkilenerek martenzitik yapıya dönüşmesi gerçekleşmiştir. Bu tür paslanmaz çeliklerin kritik soğuma hızının altında soğutulmaması için uygun tedbirlerin alınması gereklidir.In this study, the method AISI 420 TIG welding of martensitic stainless steels in the protected environment of Ar gas and 75 amps and with a weld speed of 45cm/min was carried out. For this purpose, specimens of Ø 50mm diameter and thickness of 2, 3.5, 5 and 6 mm was sliced. Weld bead was formed along the specimen for about 50mm long and following the welding, specimens were immersed into a different cooling fluids to cool to room temperature. Microhardness measurement was carried out mainly from the base metal towards the weld seam. Microstructural characteristics were investigated by optical microscope, scanning electron microscopy (SEM). As a result, the martensitic transformation of the austenitic structure has been influenced by the high cooling rate. This type of stainless steel must not be cooled below a critical cooling rate and it is necessary to take the appropriate measures