The Outcome of Antifungal Prophylaxis with Posaconazole in Patients with Acute Myeloid Leukemia: A Single-Center Study

Objective: Invasive fungal infections (IFIs) are a significant cause of morbidity and mortality among neutropenic patients undergoing chemotherapy for acute myeloid leukemia (AML) and stem cell transplantation. The aim of this study was to evaluate the real-life impact of posaconazole prophylaxis. Materials and Methods: Eighty-four adult patients were included with AML under remission induction chemotherapy and posaconazole prophylaxis. The 34 patients in the control group did not receive primary antifungal prophylaxis. The period between June 2006 and January 2009, when antifungal prophylaxis was not administered (control group), was retrospectively compared to the period between December 2010 and May 2012 when primary oral posaconazole prophylaxis was administered in similar conditions (posaconazole group) according to the use of antifungal agents for treatment, breakthrough infections, galactomannan performance, and the necessity for performing bronchoalveolar lavage (BAL) procedures. Results: The two groups were compared according to the use of antifungal agents; progression to a different antifungal agent was found in 34/34 patients (100%) in the control group and in 9/84 patients (11%) in the posaconazole group (p<0.001). There were four breakthrough IFIs (4/84, 4.8%) in the posaconazole group and 34 IFIs in the control group (p<0.001). In addition, 15/34 patients (44%) in the control group required BAL compared to 11/84 patients (13%) in the posaconazole group (p<0.001). Posaconazole treatment was discontinued within 7-14 days in 7/84 patients (8.3%) due to poor oral compliance related to mucositis after chemotherapy. Conclusion: Posaconazole appears to be effective and well-tolerated protection against IFIs for AML patients

Differential diagnosis of acute viral hepatitis by ELISA method and examination of some epidemiological features

Uludağ Üniversitesi Tıp Fakültesi Enfeksiyon Hastalıkları, Çocuk Sağlığı ve Hastalıkları klinik ve poliklinikleri ile, Bursa Devlet Hastanesi İntaniye kliniğine başvuran akut viral hepatit tanısı alan 78 hasta incelendi. Bunların, %54.4'ünde A tipi hepatit, %44.3'ünde B tipi hepatit ve %1.3'ünde ise non-A, non-B hepatiti saptandı. A tipi hepatit çocukluk çağında, B tipi hepatit ise genç erişkinlerde ağırlıklı olarak bulundu. En önemli risk grupları A tipi hepatitte öğrenciler, B tipinde ise sağlık personeli olduğu görüldü. NANB hepatitli tek olgu ise, posttransfizyonel hepatit olarak değerlendirildi

Fatal Cryptococcal Meningitis in a Patient With Chronic Lymphocytic Leukemia

&lt;p&gt;Patients with chronic lymphocytic leukemia (CLL) are susceptible to infections, especially opportunistic infections. We have described a patient with CLL who had cryptococcal meningitis. Despite lack of previous immunosuppressive treatment history, the patient experienced serious and fatal fungal infection. Physicians should be alert for a diagnosis of cryptococcal meningitis in patient with CLL who developed fever and headache.&lt;/p&gt

Real-World Data from Turkey: Is Sofosbuvir/Ledipasvir With or Without Ribavirin Treatment for Chronic Hepatitis C Really Effective?

Background: In this study, we aimed to investigate the efficacy and safety of sofosbuvir-based therapies in the treatment of chronic hepatitis C in real-world clinical practice