The high A_V Quasar Survey: A z=2.027 metal-rich damped Lyman-alpha absorber towards a red quasar at z=3.21

To fully exploit the potential of quasars as probes of cosmic chemical evolution and the internal gas dynamics of galaxies it is important to understand the selection effects behind the quasar samples and in particular if the selection criteria exclude foreground galaxies with certain properties (most importantly a high dust content). Here we present spectroscopic follow-up from the 10.4-m GTC telescope of a dust-reddened quasar, eHAQ0111+0641, from the extended High A_V Quasar (HAQ) survey. We find that the z=3.21 quasar has a foreground Damped Lyman-alpha Absorber (DLA) at z=2.027 along the line of sight. The DLA has very strong metal lines due to a moderately high metallicity (with an inferred lower limit of 25% of the solar metallicity), but a very large gas column density along the line-of-sight in its host galaxy. This discovery is further evidence that there is a dust bias affecting the census of metals, caused by the combined effect of dust obscuration and reddening, in existing samples of z>2 DLAs. The case of eHAQ0111+0641 illustrates that dust bias is not only caused by dust obscuration, but also dust reddening.Comment: 7 pages, 4 figures. Accepted for publication in A&A. A few typos have been correcte

Extinction curve template for intrinsically reddened quasars

We analyze the near-infrared to UV data of 16 quasars with redshifts ranging from 0.71 $<$ $z$ $<$ 2.13 to investigate dust extinction properties. The sample presented in this work is obtained from the High $A_V$ Quasar (HAQ) survey. The quasar candidates were selected from the Sloan Digital Sky Survey (SDSS) and the UKIRT Infrared Deep Sky Survey (UKIDSS), and follow-up spectroscopy was carried out at the Nordic Optical Telescope (NOT) and the New Technology Telescope (NTT). To study dust extinction curves intrinsic to the quasars, from the HAQ survey we selected 16 cases where the Small Magellanic Cloud (SMC) law could not provide a good solution to the spectral energy distributions (SEDs). We derived the extinction curves using Fitzpatrick & Massa 1986 (FM) law by comparing the observed SEDs to the combined quasar template from Vanden Berk et al. 2001 and Glikman et al. 2006. The derived extinction, $A_V$, ranges from 0.2-1.0 mag. All the individual extinction curves of our quasars are steeper ($R_V=2.2$-2.7) than that of the SMC, with a weighted mean value of $R_V=2.4$. We derive an `average quasar extinction curve' for our sample by fitting SEDs simultaneously by using the weighted mean values of the FM law parameters and a varying $R_V$. The entire sample is well fit with a single best-fit value of $R_V=2.2\pm0.2$. The `average quasar extinction curve' deviates from the steepest Milky Way and SMC extinction curves at a confidence level $\gtrsim95\%$. Such steep extinction curves suggest a significant population of silicates to produce small dust grains. Moreover, another possibility could be that the large dust grains may have been destroyed by the activity of the nearby active galactic nuclei (AGN), resulting in steep extinction curves.Comment: 8 pages, 4 figures, 1 tabl

Surgical or non-surgical treatment of plantar fasciopathy (SOFT):study protocol for a randomized controlled trial

BACKGROUND: Plantar fasciopathy is the most common reason for complaints of plantar heel pain and one of the most prevalent musculoskeletal conditions with a reported lifetime incidence of 10%. The condition is normally considered self-limiting with persistent symptoms that often last for several months or years. Multiple treatments are available, but no single treatment appears superior to the others. Heavy-slow resistance training and radiofrequency microtenotomy for the treatment of plantar fasciopathy have shown potentially positive effects on short- and long-term outcomes (> 3 months). However, the effect of heavy-slow resistance training compared with a radiofrequency microtenotomy treatment is currently unknown. This trial compares the efficacy of heavy-slow resistance training and radiofrequency microtenotomy treatment with supplemental standardized patient education and heel inserts in improving the Foot Health Status Questionnaire pain score after 6 months in patients with plantar fasciopathy. METHODS: In this randomized superiority trial, we will recruit 70 patients with ultrasound-confirmed plantar fasciopathy and randomly allocate them to one of two groups: (1) heavy-slow resistance training, patient education and a heel insert (n = 35), and (2) radiofrequency microtenotomy treatment, patient education and a heel insert (n = 35). All participants will be followed for 1 year, with the 6-month follow-up considered the primary endpoint. The primary outcome is the Foot Health Status Questionnaire pain domain score. Secondary outcomes include the remaining three domains of the Foot Health Status Questionnaire, a Global Perceived Effect scale, the physical activity level, and Patient Acceptable Symptom State, which is the point at which participants feel no further need for treatment. DISCUSSION: By comparing the two treatment options, we should be able to answer if radiofrequency microtenotomy compared with heavy-slow resistance training is superior in patients with plantar fasciopathy. TRIAL REGISTRATION: ClinicalTrials.gov NCT03854682. Prospectively registered on February 26, 2019. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13063-022-06785-w

The multiple strategies of an insect herbivore to overcome plant cyanogenic glucoside defence

Cyanogenic glucosides (CNglcs) are widespread plant defence compounds that release toxic hydrogen cyanide by plant β-glucosidase activity after tissue damage. Specialised insect herbivores have evolved counter strategies and some sequester CNglcs, but the underlying mechanisms to keep CNglcs intact during feeding and digestion are unknown. We show that CNglc-sequestering Zygaena filipendulae larvae combine behavioural, morphological, physiological and biochemical strategies at different time points during feeding and digestion to avoid toxic hydrolysis of the CNglcs present in their Lotus food plant, i.e. cyanogenesis. We found that a high feeding rate limits the time for plant β-glucosidases to hydrolyse CNglcs. Larvae performed leaf-snipping, a minimal disruptive feeding mode that prevents mixing of plant β-glucosidases and CNglcs. Saliva extracts did not inhibit plant cyanogenesis. However, a highly alkaline midgut lumen inhibited the activity of ingested plant β-glucosidases significantly. Moreover, insect β-glucosidases from the saliva and gut tissue did not hydrolyse the CNglcs present in Lotus. The strategies disclosed may also be used by other insect species to overcome CNglc-based plant defence and to sequester these compounds intact