A Study on Evolving Optimal Cropping Patterns in Groundwater Over-exploited Region of Perambalur District of Tamil Nadu

Falling groundwater tables and depletion of economically accessible groundwater resources would have major social and economic consequences. The present study has been taken up with the overall objective of evolving optimal crop plans to sustain the use of groundwater resources for irrigation. Perambalur district was purposively selected for the study as it mainly depends on groundwater for its irrigation. Linear programming technique was used to evolve optimal crop plans. The constraints identified were primarily irrigation water, besides land availability during the cultivating seasons and capital. Six typical farms were selected, one each for the open well, wells in tank command area and tubewell-irrigated farms in critical and over-exploited groundwater regime and also for semi-critical and safe groundwater regime. The results of the optimal crop plans derived showed that the irrigation water-use in the critical period could be reduced by 24.30, 4.54 and 51.71 hours of pumping in ordinary wells, wells in tank command area and tubewell-irrigated farms, respectively in critical and over-exploited groundwater regime sample farms. In the semi-critical and safe groundwater regime sample farms, the optimal crop plans revealed that the irrigation water-use in the critical period could be reduced by 4.61, 3.99, and 4.73 hours of pumping in ordinary wells, wells in tank command area and tubewell-irrigated farms, respectively. Area under high water intensive crops namely, paddy and sugarcane declined almost in all the optimal crop plans. Area under low water intensive crops (groundnut, gingelly and tapioca) showed an increasing trend in all optimal crop plans. The net income of the sample farms increased marginally or considerably in the optimal crop plans of both the critical and overexploited groundwater regime sample farms and semi-critical and the safe groundwater regime sample farmsAgricultural and Food Policy,

Reveiw of effective data encryption and decryption technique

The requirements of information security within an organization have undergone two major changes in the last several decades. Before the wide spread use of data processing equipment, the security of information  felt to be valuable to an organization was provided primarily by physical and administrative means. The collection of tools designed to protect data and to thwart hacker is computer security. Network security measures are needed to protect data during their transmission. This technique for encryption and decryption process to combine two methods ceaser cipher and transposition cipher, ceaser cipher is one of the substitution techniques. A substitution technique is one in which the letters of plain text are replaced by other letter or by numbers or symbols. if the plaintext is viewed as a sequence of bits, then substitution involves replacing plaintext bit patterns with cipher text bit patterns. The encryption process is two stages first, to convert the given plaintext into cipher text using ceaser cipher text technique, second stage the cipher converted using transposition technique, the final output is cipher text, The Decryption is the reverse process of the Encryption

Molecular Docking Studies for the Assessment of Wound Healing Activity of Phytoconstituents in Heliotropium Indicum

One of the most crucial and complex processes is the skin's multi-stage process of healing after an injury. Heliotropium indicum is a potent antibiotic, anti- inflammatory, anti-neoplastic, anti-oxidant, and wound- healing agent. Heliotropium indicum Linn is the source of the chemical compound in question, which is abundant in sterols, ammines, volatile oils, and the pyrrolizidine alkaloids. Molecular docking studies were conducted on Heliotropium indicum using Argus lab 4.0.1 and Autodock 1.5.7. The proteins PDB ID:1YXO, 3V18, and 4G8R were selected because of their role in wound healing. The pieces work together with the protein responsible for mending wounds. The binding affinities of mupirocin and nitrofurazone are higher than those of the components stigmasterol, eugenol, borneol, and campesterol. In order to better customize Heliotropium indicum to our requirements, we now have a better knowledge of the components of the molecule that interact with their receptors in the wound healing process

Point Absorber Method as Wave Energy Convertor Device for Power Generation: Effect of Buoy Arrangements

A point absorber is a floating structure with components that move relative to each other due to wave action. They utilize the up and down movement of the wave height at a single point for energy conversion. The relative up and down which is bobbing motion caused by passing waves used to drive electromechanical energy converters to generate power output. This experiment investigates behaviour of the point absorber device used the pneumatic sensor to take the frequency of the displacement of buoy while testing in the wave maker generator. Then, study the efficiency power output of point absorber WEC device and studies the behaviour of the point absorber in a regular wave. Fabricate the linear generator which as power absorption to estimate the effectiveness power output on different configuration by using the multimeter device. The point absorber at the front position of the configuration has good behaviour because of the high frequency produced. By estimated the behaviour of the device on configuration achieved. Configuration shape design of the point absorber used in this testing is square, diamond and parallelogram shape for an estimate the best power output. The configuration of the parallelogram has the best power output compared to another configuration. The best arrangement of the device for efficiency by measure the output voltage as power output is 68.14 mV and increase 8% in every minute

American Society for Transplantation and Cellular Therapy series: #5-Management of Clostridioides difficile infection in hematopoietic cell transplant recipients

The Practice Guidelines Committee of the American Society for Transplantation and Cellular Therapy partnered with its Transplant Infectious Disease Special Interest Group to update its 2009 compendium-style infectious disease guidelines for hematopoietic cell transplantation (HCT). A completely new approach was taken with the goal of better serving clinical providers by publishing each standalone topic in the infectious disease series as a concise format of frequently asked questions (FAQ), tables, and figures. Adult and pediatric infectious disease and HCT content experts developed and then answered FAQs and finalized topics with harmonized recommendations that were made by assigning an A through E strength of recommendation paired with a level of supporting evidence graded I through III. This fifth guideline in the series focuses on Clostridioides difficile infection with FAQs that address the prevalence, incidence, clinical features, colonization versus infection, clinical complications, diagnostic considerations, pharmacological therapies for episodic or recurrent infection, and the roles of prophylactic antibiotics, probiotics, and fecal microbiota transplantation

Multidimensional analyses reveal modulation of adaptive and innate immune subsets by tuberculosis vaccines

We characterize the breadth, function and phenotype of innate and adaptive cellular responses in a prevention of Mycobacterium tuberculosis infection trial. Responses are measured by whole blood intracellular cytokine staining at baseline and 70 days after vaccination with H4:IC31 (subunit vaccine containing Ag85B and TB10.4), Bacille Calmette-Guerin (BCG, a live attenuated vaccine) or placebo (n = ~30 per group). H4:IC31 vaccination induces Ag85B and TB10.4-specific CD4 T cells, and an unexpected NKTlike subset, that expresses IFN-γ, TNF and/or IL-2. BCG revaccination increases frequencies of CD4 T cell subsets that either express Th1 cytokines or IL-22, and modestly increases IFNγ-producing NK cells. In vitro BCG re-stimulation also triggers responses by donor-unrestricted T cells, which may contribute to host responses against mycobacteria. BCG, which demonstrated efficacy against sustained Mycobacterium tuberculosis infection, modulates multiple immune cell subsets, in particular conventional Th1 and Th22 cells, which should be investigated in discovery studies of correlates of protection

Degradability of cross-linked polyurethanes based on synthetic polyhydroxybutyrate and modified with polylactide

In many areas of application of conventional non-degradable cross-linked polyurethanes (PUR), there is a need for their degradation under the influence of specific environmental factors. It is practiced by incorporation of sensitive to degradation compounds (usually of natural origin) into the polyurethane structure, or by mixing them with polyurethanes. Cross-linked polyurethanes (with 10 and 30%wt amount of synthetic poly([R,S]-3-hydroxybutyrate) (R,S-PHB) in soft segments) and their physical blends with poly([d,l]-lactide) (PDLLA) were investigated and then degraded under hydrolytic (phosphate buffer solution) and oxidative (CoCl2/H2O2) conditions. The rate of degradation was monitored by changes of samples mass, morphology of surface and their thermal properties. Despite the small weight losses of samples, the changes of thermal properties of polymers and topography of their surface indicated that they were susceptible to gradual degradation under oxidative and hydrolytic conditions. Blends of PDLLA and polyurethane with 30 wt% of R,S-PHB in soft segments and PUR/PDLLA blends absorbed more water and degraded faster than polyurethane with low amount of R,S-PHB

TLR1/2 Activation during Heterologous Prime-Boost Vaccination (DNA-MVA) Enhances CD8+ T Cell Responses Providing Protection against Leishmania (Viannia)

Leishmania (Viannia) are the predominant agents of leishmaniasis in Latin America. Given the fact that leishmaniasis is a zoonosis, eradication is unlikely; a vaccine could provide effective prevention of disease. However, these parasites present a challenge and we do not fully understand what elements of the host immune defense prevent disease. We examined the ability of vaccination to protect against L. (Viannia) infection using the highly immunogenic heterologous prime-boost (DNA-modified vaccinia virus) modality and a single Leishmania antigen (TRYP). Although this mode of vaccination can induce protection against other leishmaniases (cutaneous, visceral), no protection was observed against L. (V.) panamensis. However, we found that if the vaccination was modified and the innate immune response was activated through Toll-like receptor1/2(TLR1/2) during the DNA priming, vaccinated mice were protected. Protection was dependent on CD8 T cells. Vaccinated mice had higher CD8 T cell responses and decreased levels of cytokines known to promote infection. Given the long-term persistence of CD8 T cell memory, these findings are encouraging for vaccine development. Further, these results suggest that modulation of TLR1/2 signaling could improve the efficacy of DNA-based vaccines, especially where CD8 T cell activation is critical, thereby contributing to effective and affordable anti parasitic vaccines