Analyses of multiplicity distributions with \eta_c and Bose-Einstein correlations at LHC by means of generalized Glauber-Lachs formula

Using the negative binomial distribution (NBD) and the generalized Glauber-Lachs (GGL) formula, we analyze the data on charged multiplicity distributions with pseudo-rapidity cutoffs \eta_c at 0.9, 2.36, and 7 TeV by ALICE Collaboration and at 0.2, 0.54, and 0.9 TeV by UA5 Collaboration. We confirm that the KNO scaling holds among the multiplicity distributions with \eta_c = 0.5 at \sqrt{s} = 0.2\sim2.36 TeV and estimate the energy dependence of a parameter 1/k in NBD and parameters 1/k and \gamma (the ratio of the average value of the coherent hadrons to that of the chaotic hadrons) in the GGL formula. Using empirical formulae for the parameters 1/k and \gamma in the GGL formula, we predict the multiplicity distributions with \eta_c = 0.5 at 7 and 14 TeV. Data on the 2nd order Bose-Einstein correlations (BEC) at 0.9 TeV by ALICE Collaboration and 0.9 and 2.36 TeV by CMS Collaboration are also analyzed based on the GGL formula. Prediction for the 3rd order BEC at 0.9 and 2.36 TeV are presented. Moreover, the information entropy is discussed

Rat interleukin-2-activated natural killer (A-NK) cell-mediated lysis is determined by the presence of CD18 on A-NK cells and the absence of major histocompatibility complex class I on target cells

The precise mechanism by which target cells are recognized and subsequently lysed by interleukin-2-activated natural killer (A-NK) cells is poorly understood. In this study the role of major histocompatibility complex (MHC) class I and adhesion molecules in the recognition and lysis of tumor cells was investigated in a syngeneic Wag rat model. Preincubation of tumor cells with F(ab′)2 fragments of anti-MHC class I monoclonal antibody (mAb) OX18 strongly enhanced the A-NK cell-mediated lysis. Also normal syngeneic cells such as T cells and A-NK cells became highly sensitive for lysis by A-NK cells after preincubation with mAb OX18. Two other mAb against MHC class I had no effect on lysis of target cells. These data indicate that masking of MHC class I on syngeneic tumor and normal cells by mAb OX18 is sufficient for A-NK cells to recognize target cells as non-self, resulting in lysis. In addition, we found that the presence of mAb against the β2 (CD18)-integrins blocked the lysis of all tumor cell lines by A-NK cells in 51Cr-release assays, also when target cells were preincubated with mAb OX18. Because of the absence of CD18 on most tumor cells we concluded that a CD18-associated integrin on A-NK cells is essential for lysis of target cells. These results show that in this syngeneic rat model CD18 on A-NK cells together with MHC class I on tumor cells determine A-NK cell-mediated lysis. Furthermore, we hypothesize that the anti-MHC class I OX18 recognizes an epitope on rat MHC class I which is, or is very close to, the restriction element determining A-NK cell-mediated lysis

Multiplicity Studies and Effective Energy in ALICE at the LHC

In this work we explore the possibility to perform ``effective energy'' studies in very high energy collisions at the CERN Large Hadron Collider (LHC). In particular, we focus on the possibility to measure in $pp$ collisions the average charged multiplicity as a function of the effective energy with the ALICE experiment, using its capability to measure the energy of the leading baryons with the Zero Degree Calorimeters. Analyses of this kind have been done at lower centre--of--mass energies and have shown that, once the appropriate kinematic variables are chosen, particle production is characterized by universal properties: no matter the nature of the interacting particles, the final states have identical features. Assuming that this universality picture can be extended to {\it ion--ion} collisions, as suggested by recent results from RHIC experiments, a novel approach based on the scaling hypothesis for limiting fragmentation has been used to derive the expected charged event multiplicity in $AA$ interactions at LHC. This leads to scenarios where the multiplicity is significantly lower compared to most of the predictions from the models currently used to describe high energy $AA$ collisions. A mean charged multiplicity of about 1000-2000 per rapidity unit (at $\eta \sim 0$) is expected for the most central $Pb-Pb$ collisions at $\sqrt{s_{NN}} = 5.5 TeV$.Comment: 12 pages, 19 figures. In memory of A. Smirnitski

Stochastic Production Of Kink-Antikink Pairs In The Presence Of An Oscillating Background

We numerically investigate the production of kink-antikink pairs in a $(1+1)$ dimensional $\phi^4$ field theory subject to white noise and periodic driving. The twin effects of noise and periodic driving acting in conjunction lead to considerable enhancement in the kink density compared to the thermal equilibrium value, for low dissipation coefficients and for a specific range of frequencies of the oscillating background. The dependence of the kink-density on the temperature of the heat bath, the amplitude of the oscillating background and value of the dissipation coefficient is also investigated. An interesting feature of our result is that kink-antikink production occurs even though the system always remains in the broken symmetry phase.Comment: Revtex, 21 pages including 7 figures; more references adde

Applicability and reproducibility of acute myeloid leukaemia stem cell assessment in a multi-centre setting

Leukaemic stem cells (LSC) have been experimentally defined as the leukaemia-propagating population and are thought to be the cellular reservoir of relapse in acute myeloid leukaemia (AML). Therefore, LSC measurements are warranted to facilitate accurate risk stratification. Previously, we published the composition of a one-tube flow cytometric assay, characterised by the presence of 13 important membrane markers for LSC detection

High resolution study of the Lambda p final state interaction in the reaction p + p -> K+ + (Lambda p)

The reaction pp -> K+ + (Lambda p) was measured at Tp=1.953 GeV and Theta = 0 deg with a high missing mass resolution in order to study the Lambda p final state interaction. The large final state enhancement near the Lambda p threshold can be described using the standard Jost-function approach. The singlet and triplet scattering lengths and effective ranges are deduced by fitting simultaneously the Lambda p invariant mass spectrum and the total cross section data of the free Lambda p scattering.Comment: submitted to Physics Letters B, 10 pages, 3 figure

The implications of carbon dioxide and methane exchange for the heavy mitigation RCP2.6 scenario under two metrics

Greenhouse gas emissions associated with Representative Concentration Pathway RCP2.6 could limit global warming to around or below a 2 °C increase since pre-industrial times. However this scenario implies very large and rapid reductions in both carbon dioxide (CO2) and non-CO2 emissions, and suggests a need to understand available flexibility between how different greenhouse gases might be abated. There is a growing interest in developing a greater understanding of the particular role of shorter lived non-CO2 gases as abatement options. We address this here through a sensitivity study of different methane (CH4) emissions pathways to year 2100 and beyond, by including exchanges with CO2 emissions, and with a focus on related climate and economic advantages and disadvantages. Metrics exist that characterise gas equivalence in terms of climate change effect per tonne emitted. We analyse the implications of CO2 and CH4 emission exchanges under two commonly considered metrics: the 100-yr Global Warming Potential (GWP-100) and Global Temperature Potential (GTP-100). This is whilst keeping CO2-equivalent emissions pathways fixed, based on the standard set of emissions usually associated with RCP2.6. An idealised situation of anthropogenic CH4 emissions being reduced to zero across a period of two decades and with the implementation of such cuts starting almost immediately gives lower warming than for standard RCP2.6 emissions during the 21st and 22nd Century. This is despite exchanging for higher CO2 emissions. Introducing Marginal Abatement Cost (MAC) curves provides an economic assessment of alternative gas reduction strategies. Whilst simpler than utilising full Integrated Assessment Models (IAMs), MAC curves are more transparent for illustrative modelling. The GWP-100 metric places a relatively high value on climate change prevented for methane emission reduction, as compared to an equivalent mass of CO2 reduction. This in combination with the strong non-linearity in MAC curves (moving quickly from relatively cheap removal to emissions difficult to cut at any cost) causes little change under cost minimisation from standard RCP2.6 emissions. This reflects the original development of RCP2.6 standard emissions from similar minimisation. With gas exchange under GTP-100, however, we find much less methane is abated, resulting in higher temperatures, whilst costs are slightly lower. Our results also highlight the point at which greater methane mitigation would become beneficial from both a climate and economic aspect. If by 2030 removal of all methane were to become possible at an average cost less than $1000 per tonne of CH4, then this would be the cheapest option, for GWP-100 metric and our CO2 MAC curve. Critically this would increase the possibility of constraining warming to two degrees