Super-Alfv\'enic propagation of reconnection signatures and Poynting flux during substorms

The propagation of reconnection signatures and their associated energy are examined using kinetic particle-in-cell simulations and Cluster satellite observations. It is found that the quadrupolar out-of-plane magnetic field near the separatrices is associated with a kinetic Alfv\'en wave. For magnetotail parameters, the parallel propagation of this wave is super-Alfv\'enic (V_parallel ~ 1500 - 5500 km/s) and generates substantial Poynting flux (S ~ 10^-5 - 10^-4 W/m^2) consistent with Cluster observations of magnetic reconnection. This Poynting flux substantially exceeds that due to frozen-in ion bulk outflows and is sufficient to generate white light aurora in the Earth's ionosphere.Comment: Submitted to PRL on 11/1/2010. Resubmitted on 4/5/201

Improving the Clinical Application of Natural Killer Cells by Modulating Signals Signal from Target Cells

Relapsed acute myeloid leukemia (AML) is a significant post-transplant complication lacking standard treatment and associated with a poor prognosis. Cellular therapy, which is already widely used as a treatment for several hematological malignancies, could be a potential treatment alternative. Natural killer (NK) cells play an important role in relapse control but can be inhibited by the leukemia cells highly positive for HLA class I. In order to restore NK cell activity after their ex vivo activation, NK cells can be combined with conditioning target cells. In this study, we tested NK cell activity against KG1a (AML cell line) with and without two types of pretreatment-Ara-C treatment that induced NKG2D ligands (increased activating signal) and/or blocking of HLA-KIR (killer-immunoglobulin-like receptors) interaction (decreased inhibitory signal). Both treatments improved NK cell killing activity. Compared with target cell killing of NK cells alone (38%), co-culture with Ara-C treated KG1a target cells increased the killing to 80%. Anti-HLA blocking antibody treatment increased the proportion of dead KG1a cells to 53%. Interestingly, the use of the combination treatment improved the killing potential to led to the death of 85% of KG1a cells. The combination of Ara-C and ex vivo activation of NK cells has the potential to be a feasible approach to treat relapsed AML after hematopoietic stem cell transplantation

Heat balance model for long-term prediction of the thermal regime of a subway tunnel and surrounding soil

For a long-term forecast of the average air temperature in a metro tunnel and surrounding soil, heat balance conditions are modeled in a system that includes two parallel tunnels, a near-tunnels underground space, the earth's surface and atmospheric air with seasonal temperature variation. It is assumed that the air in the tunnels is well mixed, and the thermal effect of ventilation is taken into account by replacing the air in the tunnels with atmospheric air. The system of heat balance equations is solved numerically by the finite element method. A numerical analysis of the influences of the model parameters on the average temperature in the tunnels and surrounding soil is carried out. The dimensions of the soil region with an elevated temperature, located between the tunnels, are estimated.Comment: 28 pages, 9 figure

Field line resonances in discretized magnetospheric models: an artifact study

International audienceFor more than two decades numerical models of the Earth's magnetosphere have been used successfully to study magnetospheric dynamic features such as the excitation of ULF pulsations and the mechanism of field line resonance. However, numerical formulations simplify important properties of the real system. For instance the Alfvén continuum becomes discrete because of a finite grid size. This discretization can be a possible source of numerical artefacts. Therefore a careful interpretation of any observed features is required. Examples of such artefacts are presented using results from a three dimensional dipole model of the magnetosphere, including an inhomogeneous distribution of the Alfvén velocity

Catastrophic chromosomal restructuring during genome elimination in plants.

Genome instability is associated with mitotic errors and cancer. This phenomenon can lead to deleterious rearrangements, but also genetic novelty, and many questions regarding its genesis, fate and evolutionary role remain unanswered. Here, we describe extreme chromosomal restructuring during genome elimination, a process resulting from hybridization of Arabidopsis plants expressing different centromere histones H3. Shattered chromosomes are formed from the genome of the haploid inducer, consistent with genomic catastrophes affecting a single, laggard chromosome compartmentalized within a micronucleus. Analysis of breakpoint junctions implicates breaks followed by repair through non-homologous end joining (NHEJ) or stalled fork repair. Furthermore, mutation of required NHEJ factor DNA Ligase 4 results in enhanced haploid recovery. Lastly, heritability and stability of a rearranged chromosome suggest a potential for enduring genomic novelty. These findings provide a tractable, natural system towards investigating the causes and mechanisms of complex genomic rearrangements similar to those associated with several human disorders

The oblique firehose instability in a bi-kappa magnetized plasma

In this work, we derive a dispersion equation that describes the excitation of the oblique (or Alfv\'en) firehose instability in a plasma that contains both electron and ion species modelled by bi-kappa velocity distribution functions. The equation is obtained with the assumptions of low-frequency waves and moderate to large values of the parallel (respective to the ambient magnetic field) plasma beta parameter, but it is valid for any direction of propagation and for any value of the particle gyroradius (or Larmor radius). Considering values for the physical parameters typical to those found in the solar wind, some solutions of the dispersion equation, corresponding to the unstable mode, are presented. In order to implement the dispersion solver, several new mathematical properties of the special functions occurring in a kappa plasma are derived and included. The results presented here suggest that the superthermal characteristic of the distribution functions leads to reductions to both the maximum growth rate of the instability and of the spectral range of its occurrence

Temperature dependence of the bandgap of Eu doped {ZnCdO/ZnO}30 multilayer structures

In situ Eu-doped {ZnCdO/ZnO}30 multilayer systems were grown on p-type Si-substrates and on quartz substrates by plasma-assisted molecular beam epitaxy. Various Eu concentrations in the samples were achieved by controlling temperature of the europium effusion cell. The properties of as-grown and annealed {ZnCdO/ZnO}30:Eu multilayers were investigated using secondary ion mass spectrometry (SIMS) and X-ray diffraction methods. SIMS measurements showed that annealing at 700{\deg}C and 900{\deg}C practically did not change the Eu concentration and the rare earth depth profiles are uniform. It was found that the band gap depends on the concentration of Eu and it was changed by rapid thermal annealing. Varshni and Bose-Einstein equations were used to describe the temperature dependence of the band gap of {ZnCdO/ZnO}30:Eu multilayer structures and Debye and Einstein temperatures were obtained.Comment: 16 pages, 8 figures, 3 table