5,879 research outputs found
Mindfulness meditation targets transdiagnostic symptoms implicated in stress-related disorders: Understanding relationships between changes in mindfulness, sleep quality, and physical symptoms
Mindfulness-Based Stress Reduction (MBSR) is an 8-week meditation program known to improve anxiety, depression, and psychological well-being. Other health-related effects, such as sleep quality, are less well established, as are the psychological processes associated with therapeutic change. This prospective, observational study (n=213) aimed to determine whether perseverative cognition, indicated by rumination and intrusive thoughts, and emotion regulation, measured by avoidance, thought suppression, emotion suppression, and cognitive reappraisal, partly accounted for the hypothesized relationship between changes in mindfulness and two health-related outcomes: sleep quality and stress-related physical symptoms. As expected, increased mindfulness following the MBSR program was directly correlated with decreased sleep disturbance (r=-0.21, p=0.004) and decreased stress-related physical symptoms (r=-0.38, p<0.001). Partial correlations revealed that pre-post changes in rumination, unwanted intrusive thoughts, thought suppression, experiential avoidance, emotion suppression, and cognitive reappraisal each uniquely accounted for up to 32% of the correlation between the change in mindfulness and change in sleep disturbance and up to 30% of the correlation between the change in mindfulness and change in stress-related physical symptoms. Results suggest that the stress-reducing effects of MBSR are due, in part, to improvements in perseverative cognition and emotion regulation, two “transdiagnostic” mental processes that cut across stress-related disorders
β Subunit M2–M3 Loop Conformational Changes Are Uncoupled from α1 β Glycine Receptor Channel Gating: Implications for Human Hereditary Hyperekplexia
Hereditary hyperekplexia, or startle disease, is a neuromotor disorder caused mainly by mutations that either prevent the surface expression of, or modify the function of, the human heteromeric α1 β glycine receptor (GlyR) chloride channel. There is as yet no explanation as to why hyperekplexia mutations that modify channel function are almost exclusively located in the α1 to the exclusion of β subunit. The majority of these mutations are identified in the M2–M3 loop of the α1 subunit. Here we demonstrate that α1 β GlyR channel function is less sensitive to hyperekplexia-mimicking mutations introduced into the M2–M3 loop of the β than into the α1 subunit. This suggests that the M2–M3 loop of the α subunit dominates the β subunit in gating the α1 β GlyR channel. A further attempt to determine the possible mechanism underlying this phenomenon by using the voltage-clamp fluorometry technique revealed that agonist-induced conformational changes in the β subunit M2–M3 loop were uncoupled from α1 β GlyR channel gating. This is in contrast to the α subunit, where the M2–M3 loop conformational changes were shown to be directly coupled to α1 β GlyR channel gating. Finally, based on analysis of α1 β chimeric receptors, we demonstrate that the structural components responsible for this are distributed throughout the β subunit, implying that the β subunit has evolved without the functional constraint of a normal gating pathway within it. Our study provides a possible explanation of why hereditary hyperekplexia-causing mutations that modify α1 β GlyR channel function are almost exclusively located in the α1 to the exclusion of the β subunit
Probably Approximately Knowing
Whereas deterministic protocols are typically guaranteed to obtain particular
goals of interest, probabilistic protocols typically provide only probabilistic
guarantees. This paper initiates an investigation of the interdependence
between actions and subjective beliefs of agents in a probabilistic setting. In
particular, we study what probabilistic beliefs an agent should have when
performing actions, in a protocol that satisfies a probabilistic constraint of
the form: 'Condition C should hold with probability at least p when action a is
performed'. Our main result is that the expected degree of an agent's belief in
C when it performs a equals the probability that C holds when a is performed.
Indeed, if the threshold of the probabilistic constraint should hold with
probaility p=1-x^2 for some small value of x then, with probability 1-x, when
the agent acts it will assign a probabilistic belief no smaller than 1-x to the
possibility that C holds. In other words, viewing strong belief as,
intuitively, approximate knowledge, the agent must probably approximately know
(PAK-know) that C is true when it acts.Comment: 23 pages, 2 figures, a full version of a paper whose extended
abstract appears in the proceeding of PODC 202
Giant microwave–optical Kerr nonlinearity via Rydberg excitons in cuprous oxide
Microwave–optical conversion is key to future networks of quantum devices, such as those based on superconducting technology. Conversion at the single quantum level requires strong nonlinearity, high bandwidth, and compatibility with a millikelvin environment. A large nonlinearity is observed in Rydberg atoms, but combining atomic gases with dilution refrigerators is technically challenging. Here, we demonstrate a strong microwave–optical nonlinearity in a cryogenic, solid-state system by exploiting Rydberg states of excitons in Cu2O. We measure a microwave–optical cross-Kerr coefficient of B0 = 0.022 ± 0.008 m V−2 at 4 K, which is several orders of magnitude larger than other solid-state systems. The results are in quantitative agreement with a nonlinear susceptibility model based on the giant microwave dipole moment between nearby excitonic states. Our results highlight the potential of Rydberg excitons for nonlinear optics and form the basis for a microwave–optical frequency converter based on Cu2O
Giant microwave-optical Kerr nonlinearity via Rydberg excitons in cuprous oxide
Microwave-optical conversion is key to future networks of quantum devices,
such as those based on superconducting technology. Conversion at the single
quantum level requires strong nonlinearity, high bandwidth, and compatibility
with a millikelvin environment. A large nonlinearity is observed in Rydberg
atoms, but combining atomic gases with dilution refrigerators is technically
challenging. Here we demonstrate that a strong microwave-optical nonlinearity
in a cryogenic, solid-state system by exploiting Rydberg states of excitons in
\cuprite. We measure a microwave-optical cross-Kerr coefficient of m V at 4~K, which is several orders of magnitude larger than
other solid-state systems. Our results highlight the potential of Rydberg
excitons for nonlinear optics, and form the basis for a microwave-optical
frequency converter based on CuO.Comment: 5 pages, 3 figure
Improved Measurement of the Positive Muon Lifetime and Determination of the Fermi Constant
The mean life of the positive muon has been measured to a precision of 11 ppm
using a low-energy, pulsed muon beam stopped in a ferromagnetic target, which
was surrounded by a scintillator detector array. The result, tau_mu =
2.197013(24) us, is in excellent agreement with the previous world average. The
new world average tau_mu = 2.197019(21) us determines the Fermi constant G_F =
1.166371(6) x 10^-5 GeV^-2 (5 ppm). Additionally, the precision measurement of
the positive muon lifetime is needed to determine the nucleon pseudoscalar
coupling g_P.Comment: As published version (PRL, July 2007
Do marketing and logistics understand each other? An empirical investigation of the interface activities between logistics and marketing
The purpose of the paper is to investigate the understanding between logistics and marketing functions, to highlight specific issues relating to the interface activities between the two areas, and to discuss the impact for business processes.
Findings are presented from a research-based case study with a major international food manufacturer, the results of which have helped the company to gain a better understanding between the marketing and logistics functions. The research has highlighted further implications for the supply chain.
The paper discusses key findings and proposes a number of recommendations for marketing and logistics educators, practitioners and researchers
Measurement of the Positive Muon Lifetime and Determination of the Fermi Constant to Part-per-Million Precision
We report a measurement of the positive muon lifetime to a precision of 1.0
parts per million (ppm); it is the most precise particle lifetime ever
measured. The experiment used a time-structured, low-energy muon beam and a
segmented plastic scintillator array to record more than 2 x 10^{12} decays.
Two different stopping target configurations were employed in independent
data-taking periods. The combined results give tau_{mu^+}(MuLan) =
2196980.3(2.2) ps, more than 15 times as precise as any previous experiment.
The muon lifetime gives the most precise value for the Fermi constant:
G_F(MuLan) = 1.1663788 (7) x 10^-5 GeV^-2 (0.6 ppm). It is also used to extract
the mu^-p singlet capture rate, which determines the proton's weak induced
pseudoscalar coupling g_P.Comment: Accepted for publication in Phys. Rev. Let
Progressive transformation of a flux rope to an ICME
The solar wind conditions at one astronomical unit (AU) can be strongly
disturbed by the interplanetary coronal mass ejections (ICMEs). A subset,
called magnetic clouds (MCs), is formed by twisted flux ropes that transport an
important amount of magnetic flux and helicity which is released in CMEs. At 1
AU from the Sun, the magnetic structure of MCs is generally modeled neglecting
their expansion during the spacecraft crossing. However, in some cases, MCs
present a significant expansion. We present here an analysis of the huge and
significantly expanding MC observed by the Wind spacecraft during 9 and 10
November, 2004. After determining an approximated orientation for the flux rope
using the minimum variance method, we precise the orientation of the cloud axis
relating its front and rear magnetic discontinuities using a direct method.
This method takes into account the conservation of the azimuthal magnetic flux
between the in- and out-bound branches, and is valid for a finite impact
parameter (i.e., not necessarily a small distance between the spacecraft
trajectory and the cloud axis). Moreover, using the direct method, we find that
the ICME is formed by a flux rope (MC) followed by an extended coherent
magnetic region. These observations are interpreted considering the existence
of a previous larger flux rope, which partially reconnected with its
environment in the front. These findings imply that the ejected flux rope is
progressively peeled by reconnection and transformed to the observed ICME (with
a remnant flux rope in the front part).Comment: Solar Physics (in press
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