115 research outputs found
Effect of Electrochemical Treatment on Electrical Conductivity of Conical Carbon Nanotubes
Interaction of conical carbon nanotubes (CNTs) with hydrogen during electrochemical treatment and its effect on their electronic properties was studied. The temperature dependencies of electroconductivity of initial and electrochemically hydrogenated conical CNTs were investigated by using four-probe van der Pauw method. The studies revealed that the electrochemical hydrogen absorption leaded to a significant reduction in the electroconductivity of conical carbon nanotubes. We assume that these changes can be associated with a decrease in the concentration of charge carriers as a result of hydrogen localization on the carbon Ο-orbitals, the transition from sp2 to sp3 hybridization of conical CNTs band structure, and, therefore, a metal-semiconductor-insulator transition
Short-Lived Electron Excitations in FeTe1 β xSex as Revealed by Microwave Absorption
Abstract: The Fe1 + yTe1 β xSex single crystals with the various Se/Te ratios were studied by the microwave absorption and direct current resistivity measurements. The comparison of the microwave absorption data and the resistivity versus temperature made it possible to separate the contributions of two types of spin fluctuations. One of them is due to the anisotropic magnetic (nematic) fluctuations. It is observed over the wide temperature range from ~30 to 150 or 200 K. In FeSe it has the maximum close to the structural transition temperature. Another MWA anomaly is located in the narrow temperature range above the superconducting transition. It is likely due to the antiferromagnetic fluctuations. Annealing of a sample at the temperature around 300Β°C in the oxygen atmosphere made it possible to exclude the effect of excess iron on the observed anomalies. Β© 2019, Pleiades Publishing, Inc
Accelerated Recovery Protocol in Extended Combined and Single-Stage Surgery for Pelvic Cancer
Introduction. The study aimed to evaluate a routine accelerated recovery management in patients with extended combined pelvic surgery.Materials and methods. We surveyed the records and outcomes in various oncological patients following the accelerated recovery protocol after a routine extended combined pelvic surgery at the Moscow City Oncology Hospital No. 1 during 2018β2020.Results and discussion. Locally advanced tumours comprised 37 (75.5 %) cases, and the remaining 12 (24.5 %) were nonpelvic resections due to metastasis. Radical surgery was achieved in 41 (83.7 %) cases, while the other 8 (16.3 %) were symptomatic due to the emerged complications of intestinal permeability disruption, bleeding, urinary obstruction, paracancrotic abscess, internal fistulae or pain syndrome. Postoperative complications were evaluated in the Clavien-Dindo classification.Conclusion. The results obtained suggest the feasibility of an accelerated recovery protocol-based practice in extended combined pelvic surgery
Ion beam synthesis and investigation of nanocomposite multiferroics based on barium titanate with 3d metal nanoparticles
Samples of nanocomposite multiferroics have been synthesized by implantation of Co+, Fe+, and Ni+ ions with an energy of 40 keV into ferroelectric barium titanate plates to doses in the range (0.5-1.5) Γ 1017 ions/cm2. It has been found that nanoparticles of metallic iron, cobalt, or nickel are formed in the barium titanate layer subjected to ion bombardment. With an increase in the implantation dose, the implanted samples sequentially exhibit superparamagnetic, soft magnetic, and, finally, strong ferromagnetic properties at room temperature. The average sizes of ion-synthesized 3d-metal nanoparticles vary in the range from 5 to 10 nm depending on the implantation dose. Investigation of the orientation dependence of the magnetic hysteresis loops has demonstrated that the samples show a uniaxial ("easy plane") magnetic anisotropy typical of thin granular magnetic films. Ferromagnetic BaTiO3: 3d metal samples are characterized by a significant shift of the ferromagnetic resonance signal in an external electric field, as well as by a large (in magnitude) magnetodielectric effect at room temperature. These results indicate that there is a strong magnetoelectric coupling between the ferroelectric barium titanate matrix and ion-synthesized nanoparticles of magnetic metals. Β© 2013 Pleiades Publishing, Ltd
ΠΠΠ ΠΠΠΠ’Π« ΠΠΠΠΠΠ¬ΠΠΠΠ ΠΠΠ§ΠΠΠΠ― ΠΠΠΠΠΠΠΠ’ΠΠ‘Π’ΠΠ’ΠΠ§ΠΠ‘ΠΠΠΠ ΠΠΠ ΠΠΠΠΠΠ― ΠΠΠ§ΠΠΠ ΠΠ Π ΠΠΠΠΠ ΠΠΠ’ΠΠΠ¬ΠΠΠ Π ΠΠΠ: ΠΠΠΠΠ ΠΠΠ’ΠΠ ΠΠ’Π£Π Π«
Liver metastases is the most common type of colorectal cancer progression. Patients who have undergone surgical resection of liver metastases and received systemic antineoplastic therapy demonstrate the highest survival rates. Recogβ nizing the oligometastatic disease as an individual entity has allowed identification of patients with advanced cancer who may benefit the most from the use of local treatment options. There are several methods of local treatment that can be currently used for the treatment of liver metastases: surgical resection, stereotactic radiation therapy, radiofrequency or microwave ablation, irreversible electroporation, and cryodestruction. The aim of our review is to provide a comparative assessment of the effectiveness, advantages and disadvantages of these techniques.ΠΠ΅ΡΠ°ΡΡΠ°Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π² ΠΏΠ΅ΡΠ΅Π½Ρ ΡΠ²Π»ΡΠ΅ΡΡΡ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΡΡΠΌ Π²Π°ΡΠΈΠ°Π½ΡΠΎΠΌ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ°ΠΊΠ° ΡΠΎΠ»ΡΡΠΎΠΉ ΠΊΠΈΡΠΊΠΈ. ΠΠ°ΠΈΠ²ΡΡΡΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΠΈ ΠΎΡΠΌΠ΅ΡΠ°ΡΡΡΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΊΠΎΡΠΎΡΡΠ΅ ΡΡΠΏΠ΅ΡΠ½ΠΎ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΡΡ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΠ΄Π°Π»Π΅Π½ΠΈΠ΅ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΎΠ² ΠΈ ΡΠΈΡΡΠ΅ΠΌΠ½ΡΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΡ. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΎΠ»ΠΈΠ³ΠΎΠΌΠ΅ΡΠ°ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΠΊΠ°ΠΊ ΠΎΡΠ΄Π΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅Π½ΠΎΠΌΠ΅Π½Π° ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΎ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²Π°ΡΡ Π² Π³ΡΡΠΏΠΏΠ΅ Π±ΠΎΠ»ΡΠ½ΡΡ
Π΄ΠΈΡΡΠ΅ΠΌΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ ΡΠ°ΠΊΠΎΠΌ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², Ρ ΠΊΠΎΡΠΎΡΡΡ
ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π»ΠΎΠΊΠ°Π»ΡΠ½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π½Π° ΠΌΠ΅ΡΠ°ΡΡΠ°Π·Ρ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΠΎΠΏΡΠ°Π²Π΄Π°Π½ΠΎ. Π ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΌ Π°ΡΡΠ΅Π½Π°Π»Π΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³Π° ΠΈΠΌΠ΅Π΅ΡΡΡ Π½Π΅ΡΠΊΠΎΠ»ΡΠΊΠΎ ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠΎΠ² Π»ΠΎΠΊΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π΄Π΅ΡΡΡΡΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π½Π° ΠΌΠ΅ΡΠ°ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΎΡΠ°Π³ΠΈ Π² ΠΏΠ΅ΡΠ΅Π½Ρ: ΡΠ΅Π·Π΅ΠΊΡΠΈΡ, ΡΡΠ΅ΡΠ΅ΠΎΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π»ΡΡΠ΅Π²Π°Ρ ΡΠ΅ΡΠ°ΠΏΠΈΡ, ΡΠ°Π΄ΠΈΠΎΡΠ°ΡΡΠΎΡΠ½Π°Ρ ΠΈΠ»ΠΈ ΠΌΠΈΠΊΡΠΎΠ²ΠΎΠ»Π½ΠΎΠ²Π°Ρ Π°Π±Π»ΡΡΠΈΡ, Π½Π΅ΠΎΠ±ΡΠ°ΡΠΈΠΌΠ°Ρ ΡΠ»Π΅ΠΊΡΡΠΎΠΏΠΎΡΠ°ΡΠΈΡ, ΠΊΡΠΈΠΎΠ΄Π΅ΡΡΡΡΠΊΡΠΈΡ. Π¦Π΅Π»ΡΡ Π½Π°ΡΠ΅Π³ΠΎ ΠΎΠ±Π·ΠΎΡΠ° ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½Π°Ρ ΠΎΡΠ΅Π½ΠΊΠ° ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π²ΡΡΠ΅ΠΏΠ΅ΡΠ΅ΡΠΈΡΠ»Π΅Π½Π½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊ, ΠΈΡ
ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ² ΠΈ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΊΠΎΠ²
Π‘ΡΠ΅ΡΠ΅ΠΎΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π»ΡΡΠ΅Π²Π°Ρ ΡΠ΅ΡΠ°ΠΏΠΈΡ ΠΏΡΠΈ ΠΎΠ»ΠΈΠ³ΠΎΠΌΠ΅ΡΠ°ΡΡΠ°Π·Π°Ρ ΠΊΠΎΠ»ΠΎΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π² ΠΏΠ΅ΡΠ΅Π½Ρ: ΡΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΎΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
The purpose of the systematic review is to summarize the data regarding safety and efficacy of stereotactic body radiation therapy in patients with oligometastases of colorectal cancer to the liver.Published scientific articles on the topic were identified by searching the databases mEDLInE, Pubmed, EmBASE. The review includes publications reporting on the results of treatment of patients undergoing stereotactic radiation therapy for. The systematic review includes all retrospective and prospective studies found over the past 15 years with at least 10 patients with liver metastases of colorectal origin included and standardized methodology of radiation therapy. We included into the review 20 studies comprising 919 patients. Comparative analysis was complicated because of the absence of control groups in all of the studies. moreover, 16 studies were single-center with heterogeneous groups of patients and various regimens of stereotaxic radiation therapy. Despite this, the researchers achieved 60β100 % rates of one-year local control, 56β100 % one-year overall survival with median overall survival up to 45 months and the number of clinically significant complications less than 10 %.From our point of view, the results of published studies support the safety and efficacy of stereotactic radiation therapy in patients with colorectal cancer and oligometastatic liver disease. we consider stereotactic body radiation therapy to be one of the local control options in case of careful patient selection and the use of modern radiation therapy options. further randomized controlled trials are needed.Π¦Π΅Π»ΡΡ ΡΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠ±Π·ΠΎΡΠ° ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΠ±ΠΎΠ±ΡΠ΅Π½ΠΈΠ΅ ΠΌΠΈΡΠΎΠ²ΠΎΠ³ΠΎ ΠΎΠΏΡΡΠ° ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΡΠ΅ΡΠ΅ΠΎΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π»ΡΡΠ΅Π²ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΠΎΠ»ΠΈΠ³ΠΎΠΌΠ΅ΡΠ°ΡΡΠ°Π·Π°ΠΌΠΈ ΠΊΠΎΠ»ΠΎΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π² ΠΏΠ΅ΡΠ΅Π½Ρ.ΠΠΏΡΠ±Π»ΠΈΠΊΠΎΠ²Π°Π½Π½ΡΠ΅ Π½Π°ΡΡΠ½ΡΠ΅ ΡΡΠ°ΡΡΠΈ ΠΏΠΎ ΡΠ΅ΠΌΠ΅ Π±ΡΠ»ΠΈ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Ρ ΠΏΡΡΠ΅ΠΌ ΠΏΠΎΠΈΡΠΊΠ° Π² Π±Π°Π·Π°Ρ
Π΄Π°Π½Π½ΡΡ
mEDLInE, Pubmed, EmBASE. Π ΠΎΠ±Π·ΠΎΡ Π²ΠΊΠ»ΡΡΠ΅Π½Ρ ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΈ, ΡΠΎΠΎΠ±ΡΠ°ΡΡΠΈΠ΅ ΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°Ρ
Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΊΠΎΡΠΎΡΡΠΌ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»Π°ΡΡ ΡΡΠ΅ΡΠ΅ΠΎΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π»ΡΡΠ΅Π²Π°Ρ ΡΠ΅ΡΠ°ΠΏΠΈΡ ΠΏΠΎ ΠΏΠΎΠ²ΠΎΠ΄Ρ ΠΌΠ΅ΡΠ°ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΏΡΠΈ ΠΊΠΎΠ»ΠΎΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΠΎΠΌ ΡΠ°ΠΊΠ΅. Π ΡΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΎΠ±Π·ΠΎΡ Π²ΠΊΠ»ΡΡΠ΅Π½Ρ Π²ΡΠ΅ Π½Π°ΠΉΠ΄Π΅Π½Π½ΡΠ΅ ΡΠ΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠ΅ ΠΈ ΠΏΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π·Π° ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ 15 Π»Π΅Ρ Ρ ΡΡΠ°ΡΡΠΈΠ΅ΠΌ Π½Π΅ ΠΌΠ΅Π½Π΅Π΅ 10 Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΈ ΡΡΠ°Π½Π΄Π°ΡΡΠΈΠ·ΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΎΠΉ Π»ΡΡΠ΅Π²ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ.Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΏΠΎΠΈΡΠΊΠ° ΠΎΡΠΎΠ±ΡΠ°Π½ΠΎ 20 ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ, Π²ΠΊΠ»ΡΡΠ°Π²ΡΠΈΡ
919 Π±ΠΎΠ»ΡΠ½ΡΡ
. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° Π·Π°ΡΡΡΠ΄Π½ΡΠ΅ΡΡΡ ΡΠ΅ΠΌ, ΡΡΠΎ Π²ΡΠ΅ Π½Π°ΠΉΠ΄Π΅Π½Π½ΡΠ΅ ΡΠ°Π±ΠΎΡΡ Π½Π΅ ΠΈΠΌΠ΅ΡΡ Π³ΡΡΠΏΠΏ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ, ΠΏΡΠΈ ΡΡΠΎΠΌ 16 ΠΈΠ· Π½ΠΈΡ
ΡΠ²Π»ΡΡΡΡΡ ΠΎΠ΄Π½ΠΎΡΠ΅Π½ΡΡΠΎΠ²ΡΠΌΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΠΌΠΈ Ρ ΡΠ°Π·Π½ΠΎΡΠΎΠ΄Π½ΡΠΌΠΈ Π³ΡΡΠΏΠΏΠ°ΠΌΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΈ ΡΠ΅ΠΆΠΈΠΌΠ°ΠΌΠΈ ΡΡΠ΅ΡΠ΅ΠΎΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π»ΡΡΠ΅Π²ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠΌΠΈ Π΄ΠΎΡΡΠΈΠ³Π½ΡΡΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΎΠ΄Π½ΠΎΠ»Π΅ΡΠ½Π΅Π³ΠΎ Π»ΠΎΠΊΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ 60β100 % ΠΏΡΠΈ ΠΎΠ΄Π½ΠΎΠ»Π΅ΡΠ½Π΅ΠΉ ΠΎΠ±ΡΠ΅ΠΉ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΠΈ 56β100 % ΠΈ ΠΌΠ΅Π΄ΠΈΠ°Π½Π΅ ΠΎΠ±ΡΠ΅ΠΉ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΠΈ Π΄ΠΎ 45 ΠΌΠ΅Ρ ΠΏΡΠΈ ΡΠΈΡΠ»Π΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΡΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ Π΄ΠΎ 10 %. Ρ Π½Π°ΡΠ΅ΠΉ ΡΠΎΡΠΊΠΈ Π·ΡΠ΅Π½ΠΈΡ, ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΎΠΏΡΠ±Π»ΠΈΠΊΠΎΠ²Π°Π½Π½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡ ΠΎ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ ΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π΄Π°Π½Π½ΠΎΠΉ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΠΎΠ»ΠΈΠ³ΠΎΠΌΠ΅ΡΠ°ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΏΡΠΈ ΠΊΠΎΠ»ΠΎΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΠΎΠΌ ΡΠ°ΠΊΠ΅. ΡΡΠ΅ΡΠ΅ΠΎΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π»ΡΡΠ΅Π²Π°Ρ ΡΠ΅ΡΠ°ΠΏΠΈΡ ΠΌΠΎΠΆΠ΅Ρ ΠΏΡΠΈΠΌΠ΅Π½ΡΡΡΡΡ ΠΊΠ°ΠΊ ΠΎΠ΄ΠΈΠ½ ΠΈΠ· Π²Π°ΡΠΈΠ°Π½ΡΠΎΠ² Π»ΠΎΠΊΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΏΡΠΈ ΡΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠΌ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠΈ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΈΠΉ, ΠΎΡΠ±ΠΎΡΠ΅ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠΈ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
Π²Π°ΡΠΈΠ°Π½ΡΠΎΠ² Π»ΡΡΠ΅Π²ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ. ΠΠ΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠΈΡ
ΡΠ°Π½Π΄ΠΎΠΌΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΊΠΎΠ½ΡΡΠΎΠ»ΠΈΡΡΠ΅ΠΌΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ
ΠΠΏΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΡΠ΅ΡΠ΅ΠΎΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π»ΡΡΠ΅Π²ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΏΡΠΈ ΠΎΠ»ΠΈΠ³ΠΎΠΌΠ΅ΡΠ°ΡΡΠ°Π·Π°Ρ ΠΊΠΎΠ»ΠΎΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π² ΠΏΠ΅ΡΠ΅Π½ΠΈ
Introduction: The problem of treating patients with unresectable liver metastases of colon cancer is currently far f rom being solved. One possible approach is the use of stereotactic body radiotherapy.The purpose of this study was to evaluate the immediate and long-term results of stereotactic radiotherapy in patients with colorectal cancer and oligometastatic liver metastases.Methods: This study was designed as a retro-prospective, open-label, controlled, non-randomized clinical trial. We assessed one-year local control, one-year overall survival, progression-free survival, and toxicity in 60 patients with oligometastatic liver disease from colorectal cancer who underwent stereotactic body radiotherapy, with median dose of 54 Gy.Results: The median follow-up was 20,1 months. One-year local control (LC) was 73,7 % (95 % CI = 62,7β86,6 %). Oneyear overall survival (OS) was 92,8 % (95 % CI = 86,3β99,9 %), one-year progression-free survival (PFS) was 31,3 % (95 % CI = 21,1β46,4 %) with a median of 8,1 months. Grade β₯ 3 toxicity was not noted. No cases of radiation-induced liver failure were observed. Radiation dose (HR = 0.88, 95 % CI = 0.81β0.95, p = 0.00087), metastasis size (HR = 1.51, 95 % CI = 1.07β2.12, p = 0.01858) and their number (HR = 1.8, 95 % CI = 1.01β3.22, p = 0.04669) are significant risk factors for LC. Metastasis size > 3 cm is a significant risk factor for LC (HR = 5.5, 95 % CI = 1.7β17.9, p = 0.005) and OS (HR = 3.8, 95 % CI = 1.3β11.7, p = 0.02).Conclusion: Stereotactic body radiotherapy is an effective and safe method of providing local control of oligometastatic liver metastases in colorectal cancer as part of a combined treatment approach. Further studies are required to individualize the indications for this treatment method.ΠΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠ΅: ΠΡΠΎΠ±Π»Π΅ΠΌΠ° Π»Π΅ΡΠ΅Π½ΠΈΡ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ Π½Π΅ΡΠ΅Π·Π΅ΠΊΡΠ°Π±Π΅Π»ΡΠ½ΡΠΌΠΈ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·Π°ΠΌΠΈ ΡΠ°ΠΊΠ° ΡΠΎΠ»ΡΡΠΎΠΉ ΠΊΠΈΡΠΊΠΈ Π² ΠΏΠ΅ΡΠ΅Π½ΠΈ Π² Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ Π΄Π°Π»Π΅ΠΊΠ° ΠΎΡ ΡΠ΅ΡΠ΅Π½ΠΈΡ. ΠΠ΄ΠΈΠ½ ΠΈΠ· Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΡ
ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΠΎΠ² β ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΡΠ΅ΡΠ΅ΠΎΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π»ΡΡΠ΅Π²ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ: ΠΡΠ΅Π½ΠΊΠ° Π½Π΅ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΈ ΠΎΡΠ΄Π°Π»Π΅Π½Π½ΡΡ
ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΡΡΠ΅ΡΠ΅ΠΎΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π»ΡΡΠ΅Π²ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π² ΡΠ°ΠΌΠΊΠ°Ρ
ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ ΡΠ°ΠΊΠ° ΡΠΎΠ»ΡΡΠΎΠΉ ΠΊΠΈΡΠΊΠΈ Ρ ΠΎΠ»ΠΈΠ³ΠΎΠΌΠ΅ΡΠ°ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΠΏΠ΅ΡΠ΅Π½ΠΈ.ΠΠ΅ΡΠΎΠ΄Ρ: ΠΠ°Π½Π½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΊΠ°ΠΊ ΡΠ΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅ ΠΎΡΠΊΡΡΡΠΎΠ΅ ΠΊΠΎΠ½ΡΡΠΎΠ»ΠΈΡΡΠ΅ΠΌΠΎΠ΅ Π½Π΅ΡΠ°Π½Π΄ΠΎΠΌΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅. ΠΠ΄Π½ΠΎΠ³ΠΎΠ΄ΠΈΡΠ½ΡΠΉ Π»ΠΎΠΊΠ°Π»ΡΠ½ΡΠΉ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ, ΠΎΠ΄Π½ΠΎΠ³ΠΎΠ΄ΠΈΡΠ½Π°Ρ ΠΎΠ±ΡΠ°Ρ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΡ, Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΡ Π±Π΅Π· ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΡ Π±ΡΠ»ΠΈ ΠΎΡΠ΅Π½Π΅Π½Ρ Ρ 60 Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΠΎΠ»ΠΈΠ³ΠΎΠΌΠ΅ΡΠ°ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΠΏΠ΅ΡΠ΅Π½ΠΈ Π½Π° ΡΠΎΠ½Π΅ ΠΊΠΎΠ»ΠΎΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ°, ΠΊΠΎΡΠΎΡΡΠΌ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»Π°ΡΡ ΡΡΠ΅ΡΠ΅ΠΎΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π»ΡΡΠ΅Π²Π°Ρ ΡΠ΅ΡΠ°ΠΏΠΈΡ, ΠΌΠ΅Π΄ΠΈΠ°Π½Π° ΡΡΠΌΠΌΠ°ΡΠ½ΠΎΠΉ ΠΎΡΠ°Π³ΠΎΠ²ΠΎΠΉ Π΄ΠΎΠ·Ρ 54 ΠΡ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ: ΠΠ΅Π΄ΠΈΠ°Π½Π° Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 20,1 ΠΌΠ΅Ρ. ΠΠ΄Π½ΠΎΠ³ΠΎΠ΄ΠΈΡΠ½ΡΠΉ Π»ΠΎΠΊΠ°Π»ΡΠ½ΡΠΉ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ (ΠΠ) Π΄ΠΎΡΡΠΈΠ³ 73,7 % (95 %ΠΠ = 62,7β86,6 %). ΠΠ΄Π½ΠΎΠ³ΠΎΠ΄ΠΈΡΠ½Π°Ρ ΠΎΠ±ΡΠ°Ρ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΡ (ΠΠ) ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 92,8 % (95 % ΠΠ = 86,3β99,9 %), ΠΎΠ΄Π½ΠΎΠ³ΠΎΠ΄ΠΈΡΠ½Π°Ρ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΡ Π±Π΅Π· ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ (ΠΠΠ) β 31,3 % (95 %ΠΠ = 21,1β46,4 %) Ρ ΠΌΠ΅Π΄ΠΈΠ°Π½ΠΎΠΉ 8,1 ΠΌΠ΅Ρ. Π’ΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ 3 ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΠΈ Π²ΡΡΠ΅ Π½Π΅ ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ. Π‘Π»ΡΡΠ°Π΅Π² ΡΠ°Π΄ΠΈΠ°ΡΠΈΠΎΠ½Π½ΠΎ ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΠ½ΠΎΠΉ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΠΈ Π½Π΅ Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΎΡΡ. ΠΡΠ»ΠΎ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π΄ΠΎΠ·Π° ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΡ (HR = 0,88, 95 % ΠΠ = 0,81β0,95, p = 0,00087), ΡΠ°Π·ΠΌΠ΅Ρ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΎΠ² (HR = 1,51, 95 % ΠΠ = 1,07β2,12, Ρ = 0,01858) ΠΈ ΠΈΡ
ΡΠΈΡΠ»ΠΎ (HR = 1,8 95 % ΠΠ = 1,01β3,22, Ρ = 0,04669) ΡΠ²Π»ΡΡΡΡΡ Π·Π½Π°ΡΠΈΠΌΡΠΌΠΈ ΡΠ°ΠΊΡΠΎΡΠ°ΠΌΠΈ ΡΠΈΡΠΊΠ° Π΄Π»Ρ ΠΠ. Π Π°Π·ΠΌΠ΅Ρ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΎΠ² > 3 ΡΠΌ ΡΠ²Π»ΡΠ΅ΡΡΡ Π·Π½Π°ΡΠΈΠΌΡΠΌ ΡΠ°ΠΊΡΠΎΡΠΎΠΌ ΡΠΈΡΠΊΠ° ΠΏΠΎ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ Π»ΠΎΠΊΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ (HR = 5.5, 95 % ΠΠ = 1.7β17.9, p = 0.005) ΠΈ ΠΠ (HR = 3.8, 95 % ΠΠ = 1.3β11.7, p = 0.02).ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅: Π‘ΡΠ΅ΡΠ΅ΠΎΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π»ΡΡΠ΅Π²Π°Ρ ΡΠ΅ΡΠ°ΠΏΠΈΡ β ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ ΠΈ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΡΠΉ ΠΌΠ΅ΡΠΎΠ΄ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ Π»ΠΎΠΊΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ Π½Π°Π΄ ΠΎΠ»ΠΈΠ³ΠΎΠΌΠ΅ΡΠ°ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΏΡΠΈ ΠΊΠΎΠ»ΠΎΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΠΎΠΌ ΡΠ°ΠΊΠ΅ Π² ΡΠ°ΠΌΠΊΠ°Ρ
ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Π° ΠΊ Π»Π΅ΡΠ΅Π½ΠΈΡ. Π’ΡΠ΅Π±ΡΠ΅ΡΡΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π΄Π»Ρ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΈΠΉ ΠΊ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΌΠ΅ΡΠΎΠ΄Π° Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΈ ΠΎΠΏΡΠΈΠΌΠΈΠ·Π°ΡΠΈΠΈ Π΅Π³ΠΎ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΠΈ.
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas
This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing
molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin
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