Transition from subbarrier to deep subbarrier regimes in heavy-ion fusion reactions

We analyze the recent experimental data of heavy-ion fusion cross sections available up to deep subbarrier energies in order to discuss the threshold incident energy for a deep subbarrier fusion hindrance phenomenon. To this end, we employ a one-dimensional potential model with a Woods-Saxon internuclear potential. Fitting the experimental data in two different energy regions with different Woods-Saxon potentials, we define the threshold energy as an intersect of the two fusion excitation functions. We show that the threshold energies so extracted are in good agreement with the empirical systematics as well as with the values of the Krappe-Nix-Sierk (KNS) potential at the touching point. We also discuss the asymptotic energy shift of fusion cross sections with respect to the potential model calculations, and show that it decreases with decreasing energies in the deep subbarrier region although it takes a constant value at subbarrier energies.Comment: 4 pages, 4 figure

Capabilities of PR professionals for key activities lag: Asia-Pacific study shows theory and practice gaps

© 2018 Elsevier Inc. A number of studies of the knowledge, skills and abilities (KSAs), competencies and capabilities of public relations and communication professionals have been carried out in the USA, UK and other countries. However, most have not engaged to any significant extent with literature in the human resource development field which specializes in defining and developing these characteristics. Also, few studies to date have related the KSAs, competencies and capabilities of practitioners to the key activities of public relations and communication management required for the future. This article presents findings and analysis from a regional survey conducted in 22 Asia-Pacific countries in 2017/18 that compared, for the first time, the capabilities of practitioners in relation to activities identified as the most important over the next three years. This data, and comparison with equivalent regional surveys in Europe and Latin America, confirm a gap in capabilities in relation to key communication activities and suggest a gap in theory as well as practice. The findings and conclusions present a challenge for higher education and professional development for public relations and communication management and point to potential future directions in theory building

PR and Communication Management in Asia-Pacific: Trends, Growth and Gaps

With a number of Asia-Pacific countries among the fastest growing in the world, the requirements for public relations and communication management are also growing in terms of both demand and professionalism. It is essential that practitioners and academics keep pace with demand and achieve ‘international best practice’. In 2015/16, the largest ever survey of PR and communication management in Asia-Pacific was launched as a biannual study, with the second survey undertaken in 2017/18. The survey is modelled on similar studies that have been conducted in Europe since 2007, in Latin American since 2014, and North America from 2018, allowing international comparison. This analysis examines key findings of the latest Asia-Pacific survey and compares results with the 2015/16 Asia-Pacific study as well as with international data to identify trends, areas of growth in professional practice, and gaps and shortcomings to be addressed. The findings are informative for educators, professional associations, and practitioners in terms of the design of undergraduate and graduate courses and ongoing training and professional development

Intelligent Phishing Detection Scheme Using Deep Learning Algorithms

Purpose: Phishing attacks have evolved in recent years due to high-tech-enabled economic growth worldwide. The rise in all types of fraud loss in 2019 has been attributed to the increase in deception scams and impersonation, as well as to sophisticated online attacks such as phishing. The global impact of phishing attacks will continue to intensify, and thus, a more efficient phishing detection method is required to protect online user activities. To address this need, this study focussed on the design and development of a deep learning-based phishing detection solution that leveraged the universal resource locator and website content such as images, text and frames. Design/methodology/approach: Deep learning techniques are efficient for natural language and image classification. In this study, the convolutional neural network (CNN) and the long short-term memory (LSTM) algorithm were used to build a hybrid classification model named the intelligent phishing detection system (IPDS). To build the proposed model, the CNN and LSTM classifier were trained by using 1m universal resource locators and over 10,000 images. Then, the sensitivity of the proposed model was determined by considering various factors such as the type of feature, number of misclassifications and split issues. Findings: An extensive experimental analysis was conducted to evaluate and compare the effectiveness of the IPDS in detecting phishing web pages and phishing attacks when applied to large data sets. The results showed that the model achieved an accuracy rate of 93.28% and an average detection time of 25 s. Originality/value: The hybrid approach using deep learning algorithm of both the CNN and LSTM methods was used in this research work. On the one hand, the combination of both CNN and LSTM was used to resolve the problem of a large data set and higher classifier prediction performance. Hence, combining the two methods leads to a better result with less training time for LSTM and CNN architecture, while using the image, frame and text features as a hybrid for our model detection. The hybrid features and IPDS classifier for phishing detection were the novelty of this study to the best of the authors' knowledge

Experimental verification of parameters in automobile crankshaft modelling for vibration analysis

In the interest of utilized more stable automobile components at high speed for reduction the vibration of mechanical system, dynamic characteristics analysis plays a vital role in complex mechanical parts. This paper introduces a clarified approach on statistical investigation and modal analysis methodology to study, predict and accurate crankshaft natural frequencies by using design of experiment (DOE). In this research, first, simulation had been done with MSC Nastran/ Patran to find out the natural frequencies in each mode shape of crankshaft as well as the verification with experiment was carried out. In order to less inaccuracy, numerous simplified crankshaft models were created by using these as input and DOE was established to acquire precise parameters of optimized crankshaft design as the second phase. This method can be further used for the optimizing the structural parameters and would provide some value basis to qualitative measure of parameters and determination of optimized structure. In Conclusion, modal verification accuracy between experimental and simulation has improved

Beneficial effect of ustekinumab in familial pityriasis rubra pilaris with a new missense mutation in CARD14

Pityriasis rubra pilaris (PRP) represents a group of rare chronic inflammatory skin disorders in which ~1 in 20 affected individuals show autosomal dominant inheritance. In such cases, there may be gain-of-function mutations in CARD14, encoding caspase recruitment domain-containing protein 14 (CARD14) that activates the non-canonical nuclear factor-kappa B (NF-κB) pathway, thereby promoting cutaneous inflammation. Here, we report a mother and son with PRP due to a new missense mutation in CARD14 and describe the beneficial clinical effects of ustekinumab, a monoclonal antibody against interleukins-12 and -23, in both subjects. A 49 year-old female and her 20 year-old son had lifelong, generalised, patchy erythematous scale with a few islands of sparing, as well as minor nail ridging and mild palmoplantar keratoderma, features consistent with generalised PRP. Topical steroids, phototherapy and oral retinoids proved ineffective therapies. Following informed consent, Sanger sequencing of CARD14 in both individuals revealed a new heterozygous single nucleotide transversion in exon 16, c.356T>G, resulting in the missense mutation, p.Met119Arg. Ustekinumab, at a dose of 45mg every 12 weeks, brought about a significant physical and emotional improvement in both the mother and son within a few days of the initial dose, which was sustained on maintenance dosing. This report highlights the therapeutic potential of biologics that downregulate NF-kB signalling in familial PRP with mutations in CARD14. This article is protected by copyright. All rights reserved

"It doesn't exist…": negotiating palliative care from a culturally and linguistically diverse patient and caregiver perspective.

BACKGROUND: The end of life represents a therapeutic context that acutely raises cultural and linguistic specificities, yet there is very little evidence illustrating the importance of such dynamics in shaping choices, trajectories and care practices. Culture and language interplay to offer considerable potential challenges to both patient and provider, with further work needed to explore patient and caregiver perspectives across cultures and linguistic groups, and provider perspectives. The objective of this study was to develop a critical, evidence-based understanding of the experiences of people from Culturally and Linguistically Diverse (CALD) backgrounds, and their caregivers, in a palliative care setting. METHODS: A qualitative study, using semi-structured interviews to explore key experiences and perspectives of CALD patients and caregivers currently undergoing treatment under oncology or palliative care specialists in two Australian hospitals. Interviews were digitally audio recorded and transcribed in full. A thematic analysis was conducted utilising the framework approach. RESULTS: Sixteen patients and fourteen caregivers from a range of CALD backgrounds participated in semi-structured interviews. The research identified four prevalent themes among participants: (1) Terminology in the transition to palliative care; (2) Communication, culture and pain management; (3) (Not) Talking about death and dying; and, (4) Religious faith as a coping strategy: challenging the terminal diagnosis. CONCLUSIONS: CALD patients and caregivers' experiences are multifaceted, particularly in negotiating linguistic difficulties, beliefs about treatment, and issues related to death and dying. Greater attention is needed to develop effective communication skills, recognise CALD patients' particular cultural, linguistic and spiritual values and needs, and acknowledge the unique nature of each doctor-patient interaction

Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison.

BACKGROUND: Artemisinin-based combinations are judged the best treatments for multidrug-resistant Plasmodium falciparum malaria. Artesunate-mefloquine is widely recommended in southeast Asia, but its high cost and tolerability profile remain obstacles to widespread deployment. To assess whether dihydroartemisinin-piperaquine is a suitable alternative to artesunate-mefloquine, we compared the safety, tolerability, efficacy, and effectiveness of the two regimens for the treatment of uncomplicated falciparum in western Myanmar (Burma). METHODS: We did an open randomised comparison of 3-day regimens of artesunate-mefloquine (12/25 mg/kg) versus dihydroartemisinin-piperaquine (6.3/50 mg/kg) for the treatment of children aged 1 year or older and in adults with uncomplicated falciparum malaria in Rakhine State, western Myanmar. Within each group, patients were randomly assigned supervised or non-supervised treatment. The primary endpoint was the PCR-confirmed parasitological failure rate by day 42. Failure rates at day 42 were estimated by Kaplan-Meier survival analysis. This study is registered as an International Standard Randomised Controlled Trial, number ISRCTN27914471. FINDINGS: Of 652 patients enrolled, 327 were assigned dihydroartemisinin-piperaquine (156 supervised and 171 not supervised), and 325 artesunate-mefloquine (162 and 163, respectively). 16 patients were lost to follow-up, and one patient died 22 days after receiving dihydroartemisinin-piperaquine. Recrudescent parasitaemias were confirmed in only two patients; the day 42 failure rate was 0.6% (95% CI 0.2-2.5) for dihydroartemisinin-piperaquine and 0 (0-1.2) for artesunate-mefloquine. Whole-blood piperaquine concentrations at day 7 were similar for patients with observed and non-observed dihydroartemisinin-piperaquine treatment. Gametocytaemia developed more frequently in patients who had received dihydroartemisinin-piperaquine than in those on artesunate-mefloquine: day 7, 18 (10%) of 188 versus five (2%) of 218; relative risk 4.2 (1.6-11.0) p=0.011. INTERPRETATION: Dihydroartemisinin-piperaquine is a highly efficacious and inexpensive treatment of multidrug-resistant falciparum malaria and is well tolerated by all age groups. The effectiveness of the unsupervised treatment, as in the usual context of use, equalled its supervised efficacy, indicating good adherence without supervision. Dihydroartemisinin-piperaquine is a good alternative to artesunate-mefloquine