7,211 research outputs found

    Numerical simulation of solid tumor blood perfusion and drug delivery during the “vascular normalization window” with antiangiogenic therapy

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    This Article is provided by the Brunel Open Access Publishing Fund - Copyright @ 2011 Hindawi PublishingTo investigate the influence of vascular normalization on solid tumor blood perfusion and drug delivery, we used the generated blood vessel network for simulations. Considering the hemodynamic parameters changing after antiangiogenic therapies, the results show that the interstitial fluid pressure (IFP) in tumor tissue domain decreases while the pressure gradient increases during the normalization window. The decreased IFP results in more efficient delivery of conventional drugs to the targeted cancer cells. The outcome of therapies will improve if the antiangiogenic therapies and conventional therapies are carefully scheduled

    A new 111 type iron pnictide superconductor LiFeP

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    A new iron pnictide LiFeP superconductor was found. The compound crystallizes into a Cu2Sb structure containing an FeP layer showing superconductivity with maximum Tc of 6K. This is the first 111 type iron pnictide superconductor containing no arsenic. The new superconductor is featured with itinerant behavior at normal state that could helpful to understand the novel superconducting mechanism of iron pnictide compounds.Comment: 3 figures + 1 tabl

    Level-set-based inverse lithography for mask synthesis using the conjugate gradient and an optimal time step

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    Confirmation Sampling for Exact Nearest Neighbor Search

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    Locality-sensitive hashing (LSH), introduced by Indyk and Motwani in STOC ’98, has been an extremely influential framework for nearest neighbor search in high-dimensional data sets. While theoretical work has focused on the approximate nearest neighbor problem, in practice LSH data structures with suitably chosen parameters are used to solve the exact nearest neighbor problem (with some error probability). Sublinear query time is often possible in practice even for exact nearest neighbor search, intuitively because the nearest neighbor tends to be significantly closer than other data points. However, theory offers little advice on how to choose LSH parameters outside of pre-specified worst-case settings. We introduce the technique of confirmation sampling for solving the exact nearest neighbor problem using LSH. First, we give a general reduction that transforms a sequence of data structures that each find the nearest neighbor with a small, unknown probability, into a data structure that returns the nearest neighbor with probability 1−δ , using as few queries as possible. Second, we present a new query algorithm for the LSH Forest data structure with L trees that is able to return the exact nearest neighbor of a query point within the same time bound as an LSH Forest of Ω(L) trees with internal parameters specifically tuned to the query and data

    Experimental Investigation on the Arc Characteristics and Arc Quenching Capabilities of C5F10O-CO2 Mixtures

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    C5F10O-CO2 mixtures are possible alternatives to SF6 - which has a high global warming potential - as the interruption medium in gas circuit breakers. This paper experimentally studies the arcing characteristics of C5F10O-CO2 mixture, with an experimental model with viewing windows, and measures the arc voltage, current and emission spectrum. The arc evolution process is captured with a high speed camera through an inspection window. The two-dimensional distribution of arc is obtained and analyzed by the inverse transformation of Abel. The results show that, the C5F10O-CO2 mixture arc is more volatile than SF6 gas, and adding C5F10O into CO2 improves the stability of the arc, and significantly reduces the arc temperature

    Trivial topological phase of CaAgP and the topological nodal-line transition in CaAg(P1-xAsx)

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    By performing angle-resolved photoemission spectroscopy and first-principles calculations, we address the topological phase of CaAgP and investigate the topological phase transition in CaAg(P1-xAsx). We reveal that in CaAgP, the bulk band gap and surface states with a large bandwidth are topologically trivial, in agreement with hybrid density functional theory calculations. The calculations also indicate that application of "negative" hydrostatic pressure can transform trivial semiconducting CaAgP into an ideal topological nodal-line semimetal phase. The topological transition can be realized by partial isovalent P/As substitution at x = 0.38.Comment: 20 pages, 4 figure
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