7 research outputs found
Role of biomarkers in early infectious complications after lung transplantation
Background Infections and primary graft dysfunction are devastating complications in the immediate postoperative period following lung transplantation. Nowadays, reliable diagnostic tools are not available. Biomarkers could improve early infection diagnosis. Methods Multicentre prospective observational study that included all centres authorized to perform lung transplantation in Spain. Lung infection and/or primary graft dysfunction presentation during study period (first postoperative week) was determined. Biomarkers were measured on ICU admission and daily till ICU discharge or for the following 6 consecutive postoperative days. Results We included 233 patients. Median PCT levels were significantly lower in patients with no infection than in patients with Infection on all follow up days. PCT levels were similar for PGD grades 1 and 2 and increased significantly in grade 3. CRP levels were similar in all groups, and no significant differences were observed at any study time point. In the absence of PGD grade 3, PCT levels above median (0.50 ng/ml on admission or 1.17 ng/ml on day 1) were significantly associated with more than two- and three-fold increase in the risk of infection (adjusted Odds Ratio 2.37, 95% confidence interval 1.06 to 5.30 and 3.44, 95% confidence interval 1.52 to 7.78, respectively). Conclusions In the absence of severe primary graft dysfunction, procalcitonin can be useful in detecting infections during the first postoperative week. PGD grade 3 significantly increases PCT levels and interferes with the capacity of PCT as a marker of infection. PCT was superior to CRP in the diagnosis of infection during the study period
Predictive accuracy of PCT values for each day of follow-up for the risk of infection, stratified by existence of primary graft dysfunction (PGD) grade 3.
<p>Predictive accuracy of PCT values for each day of follow-up for the risk of infection, stratified by existence of primary graft dysfunction (PGD) grade 3.</p
Crude and adjusted odds ratios (OR) for PCT levels (according to median) in relation to existence or not of infection.
<p>Crude and adjusted odds ratios (OR) for PCT levels (according to median) in relation to existence or not of infection.</p
Biomarker levels and primary graft dysfunction.
<p>Biomarker levels and primary graft dysfunction.</p
Median levels for PCT and CRP levels for each day of follow-up, in ‘Infection’ and ‘primary graft dysfunction (PGD) grade 3’ specifically.
<p>Median levels for PCT and CRP levels for each day of follow-up, in ‘Infection’ and ‘primary graft dysfunction (PGD) grade 3’ specifically.</p
Biomarker levels and postoperative infection.
<p>Biomarker levels and postoperative infection.</p