Comparación de la percepción de calidad de vida relacionado con la salud en hombres y mujeres adultos mayores

Introduction: The quality of life related to health is understood as the functional and emotional effect that a disease produces in a person, including treatment and how this process is perceived by the person, which may be influenced by gender.Objective: To determine the perception of quality of life related to health among men and older women in the Comarca Lagunera of Coahuila.Method: Quantitative and descriptive cross-sectional study. The sample was 100 old adults selected at convenience in the Nursing School, U.T. from the Autonomous University of Coahuila and a public hospital in the town. Data were analyzed in the SPSS v22 program for Mac, descriptive statistics and the Mann-Whitney U test were used.Results: The analysis between gender and health-related quality of life perception did not observe a significant difference (U=922.00, p=.178); However, when analyzing the quality of life by dimensions, there is a significant difference in three components that are physical mobility (U= 812.00, p< .05), pain (U= 816.00, p< .05) and energy (U= 807.50, p< .05).Conclusions: In the present investigation, it can be observed that older men and women perceive the quality of life related to health in a very similar way, however, a difference was found in some components that from the point of view of the authors, they are closely linked to the social role played by a woman or an older adult man.Introducción: La calidad de vida relacionada con la salud se entiende como el efecto funcional y anímico que una enfermedad produce en una persona, incluyendo el tratamiento y cómo este proceso es percibido por la persona, el cual puede estar influido por el género.Objetivo: Determinar la percepción de la calidad de vida relacionada con la salud entre hombre y mujeres adultos mayores en la Comarca Lagunera de Coahuila.Método: Estudio cuantitativo y descriptivo de corte transversal. La muestra estuvo conformada por 100 adultos mayores seleccionados a conveniencia en la escuela de Lic. en Enfermería, U.T. de la Universidad Autónoma de Coahuila y un hospital público de la localidad. Los datos se analizaron en el programa SPSS v22 para Mac, se utilizó estadística descriptiva y la prueba U de Mann-Withney.Resultados: El análisis entre el género y la percepción de calidad de vida relacionada con la salud no observó diferencia significativa (U= 922.00, p=.178); sin embargo, al analizar la calidad de vida por dimensiones, existe diferencia significativa en tres componentes que son movilidad física (U= 812.00, p>.05), dolor (U= 816.00, p>.05) y energía (U= 807.50, p>.05).Conclusiones: En la presente investigación, se puede observar que los hombres y mujeres adultos mayores perciben la calidad de vida relacionada a la salud de una forma muy parecida, sin embargo, se encontró diferencia en algunos componentes que desde el punto de vista de los autores están muy ligados al rol social que cumple una mujer o un hombre adulto mayor. &nbsp

Allostatic load and canine companionship: a comparative study using biomarkers in older adults

Objetivo: comparar os biomarcadores e o nível de carga alostática em uma amostra de idosos com e sem companhia canina. Método: estudo descritivo e comparativo. Os dados foram coletados por meio de uma ficha sociodemográfica e uma amostra de sangue em jejum. A carga alostática incluiu 11 biomarcadores que são mediadores primários e secundários de estresse, os quais são resultantes dos sistemas: neuroendócrino, imune, metabólico, cardiovascular e antropométrico. Resultados: houve diferença significativa em dois biomarcadores: cortisol (t= -3,091; gl=104; p=0,003) e colesterol total (t= -2,566; gl=104; p=0,012), no nível de carga alostática entre os idosos com e sem companhia canina (U= 1714,00; Z= 2,01; p= 0,044). Ao associar o nível de carga alostática com a companhia canina, houve uma maior frequência de idosos com baixa carga alostática naqueles que têm companhia canina, em comparação com aqueles que não têm a companhia canina (c2= 3,69; gl=1; p=0,043). Conclusão: a companhia canina interfere na saúde de maneira positiva, pois a carga alostática dos idosos que têm um cão como companhia é menor, além de apresentarem uma concentração menor de cortisol e de colesterol total.Objective: to compare the biomarkers and the allostatic load levels in a sample of older persons with and without canine companionship. Method: descriptive and comparative study. Data were collected using a sociodemographic questionnaire and a fasting blood sample. The allostatic load comprised 11 biomarkers that are primary and secondary stress mediators, which arise from the following systems: neuroendocrine, immune, metabolic, cardiovascular and anthropometric. Results: a significant difference was found in two biomarkers: cortisol (t= -3.091, df=104, p=0.003) and total cholesterol (t= -2.566, df=104, p=0.012), in the allostatic load levels between older adults with and without a canine companionship (U= 1714.00, Z= 2.01, p=0.044). By associating the allostatic load level with the canine companionship, there was a higher frequency of older adults with low allostatic load among those who have canine companion, compared with those who do not have canine companionship. (c2= 3.69, df=1, p= 0.043). Conclusion: canine companionship influences health in a positive way, as the allostatic load is lower in older adults who have a dog as companion, in addition to presenting lower levels of cortisol and total cholesterolObjetivo: comparar los biomarcadores y el nivel de carga alostática en una muestra de adultos mayores con y sin acompañamiento canino. Método: estudio descriptivo, comparativo. Los datos se colectaron mediante una ficha sociodemográfica y una muestra de sangre en ayuno. La carga alostática incluyó 11 biomarcadores que son mediadores primarios y secundarios del estrés, los cuales provienen de los sistemas: neuroendocrino, inmune, metabólico, cardiovascular y antropométrico. Resultados: hubo diferencia significativa en dos biomarcadores: cortisol (t=-3.091, gl=104, p=0.003) y colesterol total (t=-2.566, gl=104, p=0.012), en el nivel de carga alostática entre los adultos mayores con y sin compañía canina (U=1714.00, Z=2.01, p=0.044). Al asociar el nivel de carga alostática con la compañía canina, existió mayor frecuencia de adultos mayores con carga alostática baja en quienes son acompañados por un canino, comparado con aquellos que no tienen acompañamiento canino (c2=3.69, gl=1, p=0.043). Conclusión: el acompañamiento canino interviene en la salud de forma positiva, ya que es menor la carga alostática de los adultos mayores que tienen un perro como compañía, asimismo, presentan menor concentración de cortisol y colesterol total

A promising novel formulation for articular cartilage regeneration: Preclinical evaluation of a treatment that produces SOX9 overexpression in human synovial fluid cells

Osteoarthritis (OA) is a chronic disorder of synovial joints, in which there is progressive softening and disintegration of the articular cartilage. OA is the most common form of arthritis, and is the primary cause of disability and impaired quality of life in the elderly. Despite considerable medical necessity, no treatment has yet been proven to act as a disease‑modifying agent that may halt or reverse the structural progression of OA. The replacement of the joint with a prosthesis appears to be the best option in the advanced stages of the disease. A formulation (BIOF2) for cartilage regeneration has been recently developed. The present study evaluated the effects of BIOF2 on gene expression in human cell cultures, followed by efficacy trials in three OA animal models. Human synovial fluid cells that were exposed to the formulation exhibited increased transcription factor SOX‑9 (SOX9; chondrogenic factor) expression, and decreased mimecan (mineralization inducer) and macrophage‑stimulating protein receptor (osteoclastogenic factor) expression. The intra‑articular application of BIOF2 in the animal models significantly increased cartilage thickness from 12 to 31% at 28 days, compared with articular cartilage treated with saline solution. The articular area and number of chondrocytes additionally increased significantly, maintaining an unaltered chondrocyte/mm2 proportion. Evaluation of the histological architecture additionally displayed a decrease in the grade of articular damage in the groups treated with BIOF2. In conclusion, BIOF2 has proven to be effective for treating OA in animal models, most likely due to SOX9 overexpression in articular cells

Evidence of spatial clustering of childhood acute lymphoblastic leukemia cases in Greater Mexico City: report from the Mexican Inter-Institutional Group for the identification of the causes of childhood leukemia

BackgroundA heterogeneous geographic distribution of childhood acute lymphoblastic leukemia (ALL) cases has been described, possibly, related to the presence of different environmental factors. The aim of the present study was to explore the geographical distribution of childhood ALL cases in Greater Mexico City (GMC).MethodsA population-based case-control study was conducted. Children <18 years old, newly diagnosed with ALL and residents of GMC were included. Controls were patients without leukemia recruited from second-level public hospitals, frequency-matched by sex, age, and health institution with the cases. The residence address where the patients lived during the last year before diagnosis (cases) or the interview (controls) was used for geolocation. Kulldorff’s spatial scan statistic was used to detect spatial clusters (SCs). Relative risks (RR), associated p-value and number of cases included for each cluster were obtained.ResultsA total of 1054 cases with ALL were analyzed. Of these, 408 (38.7%) were distributed across eight SCs detected. A relative risk of 1.61 (p<0.0001) was observed for the main cluster. Similar results were noted for the remaining seven ones. Additionally, a proximity between SCs, electrical installations and petrochemical facilities was observed.ConclusionsThe identification of SCs in certain regions of GMC suggest the possible role of environmental factors in the etiology of childhood ALL

ALDA-1 protects myocardium from reperfusion damage due to its inhibitory action on mitochondrial permeability transition

413-419Reperfusion following an ischemic period represents an increased risk factor for cardiovascular morbidity and mortality. Heart reperfusion is characterized, mainly, by ventricular tachycardia, arrhythmias and a drop in blood pressure. The aim of this study was to explore the effect of the aldehyde dehydrogenase-2 agonist (ALDA-1), an inducer of the expression of the mitochondrial aldehyde dehydrogenase enzyme, on heart reperfusion damage; this is plausibly caused by the accumulation of aldehydes in the myocardium, as well as by mitochondrial permeability transition. Oxidative stress caused inhibition of cis-aconitase, increased generation of TBARs and disruption of mitochondrial DNA These adverse effects were avoided with ALDA-1 treatment

Acompañamiento psicosocial a familias en violencia doméstica del barrio Botero de Sincelejo /

Un CD- Rom (779 KB) ; 12 cmEsta propuesta de intervención trata sobre como proveer acompañamiento psicosocial a familias en violencia domestica del barrio Botero de Sincelejo, a través de la implementación de teorías como: la teoría de sistemas de Von Bertalanffy, la teoría de aprendizaje social de Alberth Bandura, teoría del estrés de Hans Selye (1907 - 1982), el modelo ecológico de Urie Bronffenbrenner y el modelo interactivo psicosocial de violencia de genero desarrollado por Stith y Rose (1992), acompañado por la metodología del modelo psicosocial de Florence Hollis y Mary Woods, Y sus métodos directos e indirectos que permiten entender y ayudar eficazmente a las personas, con violencia domestica apoyado en las técnicas de método directo (técnica de apoyo) que busca crear o reforzar actitudes favorables y conductas positivas del cliente, involucrando activamente en su propio cambio, (técnica influencia directa) piensa que el derecho del asistido a decidir por sí mismo se encuentra limitado por su capacidad de ayudarse a sí mismo, y (Discusión reflexiva) apelan a las capacidades del yo y cognitivas del asistido, al cual reconocen en general, condiciones para tomar sus propias decisiones. Logrando obtener un acompañamiento psicosocial a las familias del Barrio Botero del municipio de Sincelejo, y así proveer herramientas que le permitan a las familias tener un cambio positivo en su contexto familiar, disminuyendo los actos violentos y modificando conductas de maltara físico, psicológico y económico, y comprometiendo a la población a reflexionar y actuar sobre su realidad familiar, promover el reconocimiento de los derechos de cada uno de los integrantes de la familias. Además, se espera lograr con esta intervención psicosocial una orientación oportuna a las familias de acuerdo con los objetivos planteados, y así reflexionar sobre esta problemática social. El trabajo.PregradoTrabajador SocialTrabajo de grado(Trabajador Social) --Corporación Universitaria del Caribe. Facultad de Humanidades y Educación. Programa de Trabajo Social. Diplomado en Atención Psicosocial. Sincelejo, 2017

Interaction of Agaric Acid with the Adenine Nucleotide Translocase Induces Mitochondrial Oxidative Stress

Mitochondrial permeability transition is characterized by the opening of a transmembranal pore that switches membrane permeability from specific to nonspecific. This structure allows the free traffic of ions, metabolites, and water across the mitochondrial inner membrane. The opening of the permeability transition pore is triggered by oxidative stress along with calcium overload. In this work, we explored if oxidative stress is a consequence, rather than an effector of the pore opening, by evaluating the interaction of agaric acid with the adenine nucleotide translocase, a structural component of the permeability transition pore. We found that agaric acid induces transition pore opening, increases the generation of oxygen-derived reactive species, augments the oxidation of unsaturated fatty acids in the membrane, and promotes the detachment of cytochrome c from the inner membrane. The effect of agaric acid was inhibited by the antioxidant tamoxifen in association with decreased binding of the thiol reagent eosin-3 maleimide to the adenine nucleotide translocase. We conclude that agaric acid promotes the opening of the pore, increasing ROS production that exerts oxidative modification of critical thiols in the adenine nucleotide translocase

On the Oxidative Damage by Cadmium on Kidney Mitochondrial Functions

In the kidney, the accumulation of heavy metals, such as Cd2+, produce mitochondrial dysfunctions, i.e., uncoupling of the oxidative phosphorylation, inhibition of the electron transport through the respiratory chain, and collapse of the transmembrane electrical gradient. This derangement may be due to the fact that Cd2+ induces the transition of membrane permeability from selective to non-selective via the opening of a transmembrane pore. In fact, Cd2+ produces this injury through the stimulation of oxygen-derived radical generation conducing to oxidative stress. Several molecules have been used to avoid or even reverse the Cd2+-induced mitochondrial injury, for instance, cyclosporin A, resveratrol, dithiocarbamates, and even EDTA. The aim of the present study was to explore the possibility that tamoxifen, an antioxidant reagent, may preserve mitochondrial function from the deleterious effects of Cd2+. Our results indicate that addition of 1 ÎźM Cd2+ to mitochondria collapsed the transmembrane electrical gradient, induced the release of cytochrome c, and increased both the generation of H2O2 and the oxidative damage to mitochondrial DNA (among other measured parameters). Of interest, these mitochondrial dysfunctions were ameliorated after the addition of tamoxifen.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author

Tamoxifen Inhibits Mitochondrial Membrane Damage Caused by Disulfiram

In this work, we studied the protective effect of tamoxifen on disulfiram-induced mitochondrial membrane insult. The results indicate that tamoxifen circumvents inner membrane leakiness manifested by Ca2+ release, mitochondrial swelling, and collapse of the transmembrane electric gradient. Furthermore, it was found that tamoxifen prevents the inactivation of the mitochondrial enzyme aconitase and detachment of cytochrome c from the inner membrane. Interestingly, tamoxifen also inhibited disulfiram-promoted generation of hydrogen peroxide. Given that tamoxifen is an antioxidant molecule, it is plausible that its protection may be due to the inhibition of disulfiram-induced oxidative stress.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author