Evaluation of anthropometric facial landmarks in woman with Blepharophimosis, Ptosis, and Epicanthus Inversus Syndrome (BPES)

Introduction: Blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES) is a syndrome easily recognized by facial appearance. In this sense, the facial anthropometry is a simple and non-invasive way to evaluate the morphology of the facial surface of individuals, thus, defining the craniofacial dimensions. Objective: To evaluate the facial anthropometric measurements of a Caucasian female, aged 20 years, diagnosed with BPES and to compare these measures with the values described in the literature for non-syndromic woman.Material and methods: This research is an observational study of a Caucasian female, aged 20 years, who was diagnosed with BPES. Frontal photographs were taken, and the images analyzed by nine researchers calibrated in Image J® software. The facial measurements evaluated were head, face, orbits, nose, and labio-oral region and were compared with non-syndromic woman. Results: All vertical and horizontal face measurements were higher than that of otherfemales from Caucasian groups. BPES woman also presented bilateral ptosis and the main differences appear in the region of the orbits. Conclusion: The anthropometric facial analysis of BPES woman showed a significant change in the facial landmarks.Introduction: Blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES) is a syndrome easily recognized by facial appearance. In this sense, the facial anthropometry is a simple and non-invasive way to evaluate the morphology of the facial surface of individuals, thus, defining the craniofacial dimensions. Objective: To evaluate the facial anthropometric measurements of a Caucasian female, aged 20 years, diagnosed with BPES and to compare these measures with the values described in the literature for non-syndromic woman.Material and methods: This research is an observational study of a Caucasian female, aged 20 years, who was diagnosed with BPES. Frontal photographs were taken, and the images analyzed by nine researchers calibrated in Image J® software. The facial measurements evaluated were head, face, orbits, nose, and labio-oral region and were compared with non-syndromic woman. Results: All vertical and horizontal face measurements were higher than that of otherfemales from Caucasian groups. BPES woman also presented bilateral ptosis and the main differences appear in the region of the orbits. Conclusion: The anthropometric facial analysis of BPES woman showed a significant change in the facial landmarks

Validation of the content of the comic strip "I have diabetes and what now?"

Objective: to analyze the evidence of content validity of the comic strip "I have diabetes, what now?" Methods: methodological research into the production of health technology in the form of a comic book to support family members and hospitalized children diagnosed with type 1 diabetes mellitus. After developing the educational technology, the content was validated with six children and seven family members using a Likert scale, with indicators analyzed using the Content Validity Index. Results: the educational technology showed good validation indices according to the evaluation of the children (0.833) and family members (1,000). Conclusion: the children identified with the character in the story and agreed that it was a tool for understanding the disease, and family members said that it would be useful to disseminate the technology in other health services. Contributions to practice: there are situations that permeate aspects related to the care of children with diabetes, so the comic book could contribute to the quality of multi-professional care for this population affected by Diabetes Mellitus

A reatividade negativa oriunda da poliquimioterapia imposta na Hanseníase

Introdução: A hanseníase é uma doença infectocontagiosa, que devido às repercussões clínicas e aos dados epidemiológicos é considerada de notificação compulsória. Contudo, esse transtorno quando é precocemente identificado e adequadamente manejado, evita consideravelmente o círculo vicioso de contágio e as manifestações clínicas que tornam a doença tão alvo de estigma. Objetivo: Descrever a reação negativa oriunda da poliquimioterapia imposta na hanseníase. Metodologia: Trata-se de uma revisão narrativa de literatura, fundamentada nas plataformas do Scielo, Pubmed, Lilacs e demais literaturas pertinentes ao tema, utilizando-se os seguintes descritores: Reação Hansênica, Efeitos Adversos e Poliquimioterapia, no período de janeiro de 2023. Resultados e Discussão:  Atualmente, o protocolo terapêutico voltado para a Hanseníase é a poliquimioterapia e possui boa eficácia e tolerância pela maioria dos pacientes.  No advém, a minoria destes apresenta reações adversas que variam de leve a exacerbadas e que devem ser devidamente classificados e orientados para outras opções farmacológica, objetivando impedir que o paciente abandone o tratamento, junto às enormes repercussões oriundas deste, e propiciar melhor qualidade de vida. Conclusão: Estima-se que o tratamento da Hanseníase é algo importante e indispensável para evitar problemas de saúde pública, mas este se baseia em uma alta carga associada de remédios potentes, a qual alguns portadores possuem sensibilidade e se orientados, podem continuar o tratamento até o alcance da cura.&nbsp

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

Promoção à saúde com trabalhadores de saúde mental

Objective: To report the experience of undergraduate students in the development of health promotion actions with mental health workers. Data Synthesis: This experience report was developed by nursing students from a university in Rio Grande do Sul, Brazil, to address the development of health promotion actions with mental health workers. A total of eight meetings were held from 2015 to 2016 and the themes addressed were aimed at the reflection and discussion about the work process, professionals’ quality of life, and performance of activities to promote occupational health using spaces for reflection and activities to promote health and prevent diseases. Conclusion: The activities held by undergraduate students with the population of mental health workers favored a differentiated look at the aspects that involve occupational health and allowed the development of interdisciplinary teamwork among undergraduate courses.Objetivo: Relatar la experiencia de discentes de graduación para el desarrollo de acciones de promoción de la salud de trabajadores de salud mental. Síntesis de los datos: Se trata de un relato de experiencia realizada por discentes de Enfermería de una universidad de Rio Grande do Sul, Brasil, sobre el desarrollo de acciones de promoción de la salud de trabajadores de salud mental. Se realizaron ocho encuentros en el periodo entre 2015 y 2016 cuyos temas se han destinado para la reflexión y discusión del proceso de trabajo y calidad de vida de los profesionales así como la realización de actividades para la promoción de la salud laboral a partir de espacios para reflexión y actividades de promoción de la salud y prevención de agravios. Conclusión: Las actividades realizadas por los discentes de graduación con la población de trabajadores de salud mental ofrecieron una mirada diferenciada de los aspectos que involucran la salud del trabajador así como ha promovido el desarrollo de un trabajo en equipo e interdisciplinar entre los cursos de grado.Objetivo: Relatar a experiência de discentes de graduação no desenvolvimento de ações de promoção à saúde com trabalhadores de saúde mental. Síntese dos dados: Trata-se de um relato de experiência realizada por discentes de Enfermagem de uma universidade do Rio Grande do Sul, Brasil, de desenvolvimento de ações de promoção à saúde com trabalhadores de saúde mental. Foram realizados oito encontros, no período de 2015 a 2016, cujos temas destinaram-se à reflexão e discussão do processo de trabalho e qualidade de vida dos profissionais, bem como à realização de atividades para promoção da saúde ocupacional, a partir de espaços de reflexão e atividades de promoção da saúde e prevenção de agravos. Conclusão: As atividades realizadas pelos discentes de graduação junto à população de trabalhadores de saúde mental oportunizaram um olhar diferenciado sobre os aspectos que envolvem a saúde do trabalhador, bem como propiciaram o desenvolvimento de um trabalho em equipe e interdisciplinar entre os cursos de graduação

The First Optimization Process from Cultivation to Flavonoid-Rich Extract from Moringa oleifera Lam. Leaves in Brazil

Flavonoids are significant antioxidant and anti-inflammatory agents and have multiple potential health applications. Moringa oleifera is globally recognized for its nutritional and pharmacological properties, correlated to the high flavonoid content in its leaves. However, the bioactive compounds found in plants may vary according to the cultivation, origin, season, and extraction process used, making it difficult to extract reliable raw material. Hence, this study aimed to standardize the best cultivation and harvest season in Brazil and the best extraction process conditions to obtain a flavonoid-rich extract from M. oleifera as a final product. Firstly, ultrasound-assisted extraction (UAE) was optimized to reach the highest flavonoid content by three-level factorial planning and response surface methodology (RSM). The optimal cultivation condition was mineral soil fertilizer in the drought season, and the optimized extraction was with 80% ethanol and 13.4 min of extraction time. The flavonoid-rich extract was safe and significantly decreased reactive oxygen species (ROS) and nitric oxide (NO) in LPS-treated RAW 264.7 cells. Lastly, the major flavonoids characterized by HPLC-ESI-QTRAP-MS/MS were compounds derived from apigenin, quercetin, and kaempferol glycosides. The results confirmed that it was possible to standardize the flavonoid-rich extract leading to a standardized and reliable raw material extracted from M. oleifera leaves