DEIKSIS DALAM LIRIK LAGU ALIN COEN

This research aims to describe the deixis contained in Alin Coen's song lyrics using George Yule's deixis theory because songs are poetic texts with short sentences that have similarities in form and structure of meaning with poetry so that in-depth analysis is needed and George Yule's deixis theory is used to help in understanding the meaning of the song so that the song can be understood better. This research will discuss how the form of deixis in the five lyrics of Alin Coen's songs using a qualitative approach, then the data will be presented descriptively. The data sources used are the songs Ich war hier, Wer bist du, Das letzte Lied, Die Naehe, and Wolken and the data used in this research are words or phrases that refer to persona deixis, place deixis and time deixis. The data that has been collected by listening and recording techniques will then be analyzed and classified based on the type of deixis. Based on the analysis of the five Alin Coen song lyrics, persona deixis consisting of Ich, Du, Er, Sie, Es and Wir have been found. Place deixis consists of Da, Hier, Der Weg and Hinter. The time deixis consists of Irgendwann and Jetzt

The effects of information content of cash flow statement, dividend payout ratio, economic value added and corporate social responsibility on stock trading volume

Purpose - This study aims to empirically test and analyze the influence of information content of cash flow statements, Dividend Payout Ratio (DPR), Economic Value Added (EVA) Corporate Social Responsibility (CSR) on the trading volume of empirical study stocks in manufacturing companies listed on the Indonesia Stock Exchange from 2014 to 2018.  Method - The number of samples used in this study was 169 taken from financial report on idx. The analytical techniques used were multiple regressions in order to obtain a comprehensive picture of the relationship between variable and each other. This research used a quantitative approach with its research population of companies included in the manufacturing sector listed on the Indonesia Stock Exchange in 2014- 2018..Result - Based on the results of this study, investment cash flow and Dividend Payout Ratio (DPR) significantly influenced the trading volume of stocks. Meanwhile, operating cash flow, funding cash flow, Economic Value Added (EVA) and Corporate Social Responsibility (CSR) had no significant effect on stock trading volume.Implication - This research is suggested to improve development of trading volume in investor decision making for investment and for companys’ performance assessment.Originality - This research is the study that used content of cash flow resporting information, dividend payout ratio, economic value added, corporate social responsibility on stock trading volume

The effects of information content of cash flow statement, dividend payout ratio, economic value added and corporate social responsibility on stock trading volume

Purpose - This study aims to empirically test and analyze the influence of information content of cash flow statements, Dividend Payout Ratio (DPR), Economic Value Added (EVA) Corporate Social Responsibility (CSR) on the trading volume of empirical study stocks in manufacturing companies listed on the Indonesia Stock Exchange from 2014 to 2018.  Method - The number of samples used in this study was 169 taken from financial report on idx. The analytical techniques used were multiple regressions in order to obtain a comprehensive picture of the relationship between variable and each other. This research used a quantitative approach with its research population of companies included in the manufacturing sector listed on the Indonesia Stock Exchange in 2014- 2018..Result - Based on the results of this study, investment cash flow and Dividend Payout Ratio (DPR) significantly influenced the trading volume of stocks. Meanwhile, operating cash flow, funding cash flow, Economic Value Added (EVA) and Corporate Social Responsibility (CSR) had no significant effect on stock trading volume.Implication - This research is suggested to improve development of trading volume in investor decision making for investment and for companys’ performance assessment.Originality - This research is the study that used content of cash flow resporting information, dividend payout ratio, economic value added, corporate social responsibility on stock trading volume

PENGARUH PENERAPAN METODE BERMAIN PERAN (ROLE PLAYING) TERHADAP KECERDASAN LINGUISTIK-VERBAL ANAK KELOMPOK A DI TK AISYIYAH 3

Penelitian pada anak kelompok A di TK Aisyiyah 3 Surabaya dilatarbelakangi oleh rendahnya kecerdasan linguistik-verbal pada anak, penyebabnya yaitu kurangnya inovasi pembelajaran yang diberikan guru. Tujuan yang ingin dicapai dari penelitian ini yaitu untuk mengetahui ada atau tidak pengaruh penggunaan metode bermain peran (Role Playing) terhadap kecerdasan linguistik-verbal anak kelompok A di TK Aisyiyah 3 Surabaya. Penelitian ini menggunakan pendekatan penelitian kuantitatif dengan jenis pre-experimental dan desain penelitian one group pretest-posttest. Subyek penelitian berjumlah 24 anak. Metode pengumpulan data menggunakan observasi dengan alat penilaian berupa lembar observasi dan dokumentasi berupa foto. Analisis data menggunakan statistik non-parametrik uji jenjang bertanda Wilcoxon (wilcoxon match pairs test), dengan rumus T hitung < T tabel. Penelitian ini dikatakan signifikan karena adanya pengaruh dua variabel jika Thitung < T tabel.  Berdasarkan hasil analisis data tentang kecerdasan linguistik-verbal pada saat observasi awal (pre-test) dan observasi setelah perlakuan (post-test) menggunakan metode bermain peran (Role Playing) diperoleh nilai rata-rata hasil pre-test 9,42 dan rata-rata hasil post-test 14,45. Hasil perhitungan dengan uji jenjang diperoleh t hitung= 0 lebih kecil dari t tabel= 81 dan hasil pengambilan keputusannya yaitu: Ha diterima karena t hitung < t tabel (0<81) dan Ho ditolak karena t hitung > t tabel (0>81). Simpulan penelitian menunjukkan bahwa metode bermain peran (Role playing) berpengaruh secara signifikan terhadap kecerdasan linguistik-verbal pada anak kelompok A di TK Aisyiyah 3 Surabaya.Kata kunci: Metode Bermain Peran, Kecerdasan Linguistik-Verbal.AbstractThis research was motivated by the low linguistic-verbal intelligence on the children at Aisyiyah 3 Surabaya kindergarten. The aim of this study was to determine whether the Role Play method application affect the children’s linguistic-verbal intelligent in Aisyiyah 3 Surabaya kindergarten.This study used a quantitative research approach with the pre-experimental and pretest-posttest design. The research subjects were 24 children. The data collection technique in this study used observation with assessment tool such as observation sheets and documentation in the form of photographs. The statistical analysis used a non-parametric Wilcoxon test marked level (Wilcoxon matched pairs test). Based on the data analysis on the linguistic-verbal intelligence at the beginning observation (pre-test) and the observation after the treatment (post-test) using Role Play method, it was acknowledged that the average score of pre-test was 9.42 and 14.45 on the post-test. The calculation result obtained with test levels was tcount = 0 is smaller than ttable= 81. Hence, it can be concluded: Ha is accepted because tcount< ttable( 0 < 81 ) and Ho is rejected because tcount> ttable ( 0 > 81 ). The conclusion of the study was Role Play method significantly influence the children’s linguistic-verbal intelligence in Aisyah Surabaya 3 Kindergarten. It proved that the Role Play method can help the children to understand and follow the simple commands, Stringing words to communicate, Trying to write a basic alphabet, Start reading simple words, and Shows interest in books.Keywords : Method of Role Playing , Linguistic - Verbal Intelligence .   Pengaruh Penerapan Metode Bermain Peran (Role Playing) Terhadap Kecerdasaan Linguistik-Verbal Anak Kelompo

Barriers to kidney transplants in Indonesia : a literature review

Background: People living with chronic kidney disease will require renal dialysis or a kidney transplant to maintain life. Although Indonesia has a developing healthcare industry, Indonesia\u27s kidney transplant rates are lower than comparable nations.Purpose: To explore the healthcare literature to identify barriers to kidney transplants in particular in relation to Indonesia.Methods: Healthcare databases were searched (CINAHL, Medline, EBSCOhostEJS, Blackwell Synergy, Web of Science, PubMed, Google Scholar and Proquest 5000) using the search terms: transplant, kidney disease, renal, dialysis, haemodialysis, Indonesia and nursing. The search was limited to English and Indonesian language data sources from 1997 to 2007. Reference lists of salient academic articles were hand searched.Results: The results of our search identified six articles that met our criteria. Costs are the major barrier to kidney transplant in Indonesia, followed by cultural beliefs, perception of the law, lack of information and lack of infrastructure. In addition, kidney disease prevention strategies are required.Conclusions: There are many complex socio-economic, geographical, legal, cultural and religious factors that contribute to low kidney transplant rates in Indonesia. Although an increase in transplantation rates will require strategies from various agencies, healthcare professionals, including nurses, can play a role in overcoming some barriers. Community education programmes, improving their own education levels and by increasing empowerment in nursing we may contribute to improved kidney transplant rates in Indonesia.<br /

Pharmacometrics of high dose ivermectin in early COVID-19: an open label, randomized, controlled adaptive platform trial (PLATCOV)

Background: There is no generally accepted methodology for in vivo assessment of antiviral activity in SARS-CoV-2 infections. Ivermectin has been recommended widely as a treatment of COVID-19, but whether it has clinically significant antiviral activity in vivo is uncertain. Methods: In a multicentre open label, randomized, controlled adaptive platform trial, adult patients with early symptomatic COVID-19 were randomized to one of six treatment arms including high-dose oral ivermectin (600 µg/kg daily for 7 days), the monoclonal antibodies casirivimab and imdevimab (600 mg/600 mg), and no study drug. The primary outcome was the comparison of viral clearance rates in the modified intention-to-treat population. This was derived from daily log10 viral densities in standardized duplicate oropharyngeal swab eluates. This ongoing trial is registered at https://clinicaltrials.gov/ (NCT05041907). Results: Randomization to the ivermectin arm was stopped after enrolling 205 patients into all arms, as the prespecified futility threshold was reached. Following ivermectin, the mean estimated rate of SARS-CoV-2 viral clearance was 9.1% slower (95% confidence interval [CI] –27.2% to +11.8%; n=45) than in the no drug arm (n=41), whereas in a preliminary analysis of the casirivimab/imdevimab arm it was 52.3% faster (95% CI +7.0% to +115.1%; n=10 (Delta variant) vs. n=41). Conclusions: High-dose ivermectin did not have measurable antiviral activity in early symptomatic COVID-19. Pharmacometric evaluation of viral clearance rate from frequent serial oropharyngeal qPCR viral density estimates is a highly efficient and well-tolerated method of assessing SARS-CoV-2 antiviral therapeutics in vitro

Prognostic significance of tumor-infiltrating lymphocytes in predicting outcome of distal cholangiocarcinoma in Thailand

Patients with distal cholangiocarcinoma (dCCA) generally have poor outcomes because of late presentation and diagnosis. Therefore, prognostic factors for predicting outcomes are essential to improve therapeutic strategies and quality of life. Tumor-infiltrating lymphocytes (TILs) have been reported as a prognostic predictor in several cancers. However, their role in dCCA is still unclear. This study aimed to evaluate the association of TILs with outcome in patients with dCCA. Fifty-two patients were evaluated for the percentage rate of TILs in their cancers, and a median TIL level was used to divide the patients into two groups. Survival, multivariate, and correlation analyses were performed to determine the prognostic factors. Results showed that a low TIL level was associated with poor survival. Multivariate analysis revealed TILs as an independent factor for poor outcome. Moreover, TILs were markedly correlated with growth patterns, and both were applied to classify patients with dCCA. Subgroups of TILs with growth pattern incorporation improved stratification performance in separating good from poor patient outcomes. This study suggested that TILs could be a prognostic factor for predicting survival and for clustering patients with dCCA to improve prognostication capability. This finding may be incorporated into a new staging system for stratifying dCCA in Thailand

Clinical antiviral efficacy of remdesivir in coronavirus disease 2019: an open-label, randomized controlled adaptive platform trial (PLATCOV)

Background Uncertainty over the therapeutic benefit of parenteral remdesivir in coronavirus disease 2019 (COVID-19) has resulted in varying treatment guidelines. Methods In a multicenter open-label, controlled, adaptive, pharmacometric platform trial, low-risk adult patients with early symptomatic COVID-19 were randomized to 1 of 8 treatment arms including intravenous remdesivir (200 mg followed by 100 mg daily for 5 days) or no study drug. The primary outcome was the rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) clearance (estimated under a linear model fit to the daily log10 viral densities, days 0–7) in standardized duplicate oropharyngeal swab eluates, in a modified intention-to-treat population. This ongoing adaptive trial is registered at ClinicalTrials.gov (NCT05041907). Results The 2 study arms enrolled 131 patients (remdesivir n = 67, no study drug n = 64) and estimated viral clearance rates from a median of 18 swab samples per patient (a total of 2356 quantitative polymerase chain reactions). Under the linear model, compared with the contemporaneous control arm (no study drug), remdesivir accelerated mean estimated viral clearance by 42% (95% credible interval, 18%–73%). Conclusions Parenteral remdesivir accelerates viral clearance in early symptomatic COVID-19. Pharmacometric assessment of therapeutics using the method described can determine in vivo clinical antiviral efficacy rapidly and efficiently