The Strabo Technique

The Strabo technique is a forecasting and planning strategy whose methodology emphasizes the determination of a concensus of opinion from a group of experts. It is a logical extension of the Delphi technique which was developed originally to assist the decision making processes of the American military (Linstone and Turnoff, 1975, p. 10). Many of the early studies employing Delphi were conducted at the RAND Corporation and were primarily concerned with scientific and technological forecasting. The Delphi Technique has since been used in a variety cf studies including the forecasting of many social "indicators\u27\u27 such as human attitudes are values, and the "quality of life". The technique requires individuals within a group to formulate and assess decisions and opinions and, through this process, establish a convergent group consensus

Revisión de la distribución de pequeños cetaceos frente al Perú

Review of the distribution of small cetaceans off Peru. The little information available on the occurrence of small cetaceans in Peruvian marine waters is reviewed. Data obtained between 1982 and 1987 by port monitoring, surveys of beaches and fish dumps, and sightings are included.Eighteen species of small cetaceans, belonging to four families, are presently known to occur at least occasionally within the 200 nautical miles limit of Peruvian marine waters; six species (markes with asterisk) represent new records for the study area. The species are: Phocoens spinipinnis, Tursiops truncatus, Grampus griseus; Lagenorhynchus obscurus; Delphinus delphis; Stenella attenuate; S. longirostris; S. coerulealba; Peponocephala electra (*); Feresa attenuate (*); Globicephala melaena; G. macrorhynchus (*); Pseudorca crassidens; Orcinus orca; Kogia breviceps; K. simus (*); Ziphius cavirostris (*); Mesoploson sp. (*)

Mapping landscape-scale peatland degradation using airborne lidar and multispectral data

This is the final version. Available on open access from Springer via the DOI in this recordContext An increased interest in the restoration of peatlands for delivering multiple benefits requires a greater understanding of the extent and location of natural and artificial features that contribute to degradation. Objectives We assessed the utility of multiple, fine-grained remote sensing datasets for mapping peatland features and associated degraded areas at a landscape-scale. Specifically, we developed an integrated approach to identify and quantify multiple types of peatland degradation including: anthropogenic drainage ditches and peat cuttings; erosional gullies and bare peat areas. Methods Airborne LiDAR, CASI and aerial image datasets of the South West UK, were combined to identify features within Dartmoor National Park peatland area that contribute to degradation. These features were digitised and quantified using ArcGIS before appropriate buffers were applied to estimate the wider ecohydrologically affected area. Results Using fine-scale, large-extent remotely sensed data, combined with aerial imagery enabled key features within the wider expanse of peatland to be successfully identified and mapped at a resolution appropriate to future targeted restoration. Combining multiple datasets increased our understanding of spatial distribution and connectivity within the landscape. An area of 29 km2 or 9.2% of the Dartmoor peatland area was identified as significantly and directly ecohydrologically degraded. Conclusions Using a combination of fine-grained remotely sensed datasets has advantages over traditional ground survey methods for identification and mapping of anthropogenic and natural erosion features at a landscape scale. The method is accurate, robust and cost-effective particularly given the remote locations and large extent of these landscapes, facilitating effective and targeted restoration planning, management and monitoring.Dartmoor National Park AuthorityDartmoor Peatland PartnershipDuchy of CornwallEnvironment AgencyForestry CommissionMinistry of DefenceNatural EnglandSouth West partnership for Environmental and Economic Prosperity (SWEEP)South West WaterNatural Environment Research Council (NERC

Ligand Decomposition during Nanoparticle Synthesis: Influence of Ligand Structure and Precursor Selection

Aliphatic amine and carboxylic acid ligands are widely used as organic solvents during the bottom-up synthesis of inorganic nanoparticles (NPs). Although the ligands’ ability to alter final NP properties has been widely studied, side reactivity of these ligands is emerging as an important mechanism to consider. In this work, we study the thermal decomposition of common ligands with varying functional groups (amines and carboxylic acids) and bond saturations (from saturated to polyunsaturated). Here, we investigate how these ligand properties influence decomposition in the absence and presence of precursors used in NP synthesis. We show that during the synthesis of inorganic chalcogenide NPs (Cu2ZnSnS4, CuxS, and SnSx) with metal acetylacetonate precursors and elemental sulfur, the ligand pyrolyzes, producing alkylated graphitic species. Additionally, there was less to no ligand decomposition observed during the sulfur-free synthesis of ZnO and CuO with metal acetylacetonate precursors. These results will help guide ligand selection for NP syntheses and improve reaction purity, an important factor in many applications.journal articl

The unexpected fast polymerization during the synthesis of a glycolated polythiophene

Conjugated polymers with ethylene glycol side chains are emerging as ideal materials for bioelectronics, particularly for application in organic electrochemical transistors (OECTs). To improve the OECT device performance, it is important to develop an efficient synthetic strategy that will provide access to novel high-performing materials besides focusing on molecular design. While a lot of efforts are being devoted to designing of new polymers by modifying the glycol side chains, understanding how their nature affects the polymerization kinetics and eventually the polymer structure and properties is not known. In this work, we have studied the influence of the content of the ethylene glycol side chain and its linkage on the formation of the active Grignard monomer species upon Grignard metathesis in three thiophene derivatives. A strong dependence of the monomer's concentration on polymerization was noted in our study indicating that for synthesizing P3MEEMT, a high-performing OECT material, by Kumada catalyst transfer polymerization (KCTP) a minimum of 0.15 M monomer is needed. Furthermore, kinetic studies by GPC show uncontrolled polymerization behavior contrary to the controlled chain growth characteristics of the KCTP.journal articl

Advances in applying C–H functionalization and naturally sourced building blocks in organic semiconductor synthesis

Organic electronics is a rising field, with novel applications including but not limited to stretchable solar cells, flexible display screens, and biosensors. The high performance of these organic electronics is enabled by the outstanding optoelectronic and thermomechanical features of organic semiconducting materials. However, the production of the promising organic semiconducting materials at industrial scales has not yet become feasible, due to huge energy and capital costs in the large-scale synthesis as well as the potential damage to the environment and human health caused by vast hazardous chemical waste released. This review summarizes recent research advances in improving the environmental friendliness of the organic semiconducting material synthesis by appying atom economical C–H functionalization-based synthetic routes, minimizing hazardous chemical waste, lowering the energy consumption, and employing safe and abundant chemicals including naturally sourced semiconducting building blocks. This review showcases the remarkable progress that has been made towards the environmentally friendly organic semiconductor synthesis and provides insight for researchers developing green synthetic strategies and organic semiconductor building blocks in the future

Implementing medical revalidation in the United Kingdom: Findings about organisational changes and impacts from a survey of Responsible Officers.

Objective To describe the implementation of medical revalidation in healthcare organisations in the United Kingdom and to examine reported changes and impacts on the quality of care. Design A cross-sectional online survey gathering both quantitative and qualitative data about structures and processes for medical revalidation and wider quality management in the organisations which employ or contract with doctors (termed 'designated bodies') from the senior doctor in each organisation with statutory responsibility for medical revalidation (termed the 'Responsible Officer'). Setting United Kingdom Participants Responsible Officers in designated bodies in the United Kingdom. Five hundred and ninety-five survey invitations were sent and 374 completed surveys were returned (63%). Main outcome measures The role of Responsible Officers, the development of organisational mechanisms for quality assurance or improvement, decision-making on revalidation recommendations, impact of revalidation and mechanisms for quality assurance or improvement on clinical practice and suggested improvements to revalidation arrangements. Results Responsible Officers report that revalidation has had some impacts on the way medical performance is assured and improved, particularly strengthening appraisal and oversight of quality within organisations and having some impact on clinical practice. They suggest changes to make revalidation less 'one size fits all' and more responsive to individual, organisational and professional contexts. Conclusions Revalidation appears primarily to have improved systems for quality improvement and the management of poor performance to date. There is more to be done to ensure it produces wider benefits, particularly in relation to doctors who already perform well

Intersectionality: Social Marginalisation and Self-Reported Health Status in Young People.

BACKGROUND:The aim of this study was to measure young people's health status and explore associations between health status and belonging to one or more socio-culturally marginalised group. METHODS:part of the Access 3 project, this cross-sectional survey of young people aged 12-24 years living in New South Wales, Australia, oversampled young people from one or more of the following groups: Aboriginal and or Torres Strait Islander; living in rural and remote areas; homeless; refugee; and/or, sexuality and/or gender diverse. This paper reports on findings pertaining to health status, presence of chronic health conditions, psychological distress, and wellbeing measures. RESULTS:1416 participants completed the survey; 897 (63.3%) belonged to at least one marginalised group; 574 (40.5%) to one, 281 (19.8%) to two and 42 (3.0%) to three or four groups. Belonging to more marginalised groups was significantly associated with having more chronic health conditions (p = 0.001), a greater likelihood of high psychological distress (p = 0.001) and of illness or injury related absence from school or work (p < 0.05). CONCLUSIONS:increasing marginalisation is associated with decreasing health status. Using an intersectional lens can to be a useful way to understand disadvantage for young people belonging to multiple marginalised groups

Chromatin-contact atlas reveals disorder-mediated protein interactions and moonlighting chromatin-associated RBPs

RNA-binding proteins (RBPs) play diverse roles in regulating co-transcriptional RNA-processing and chromatin functions, but our knowledge of the repertoire of chromatin-associated RBPs (caRBPs) and their interactions with chromatin remains limited. Here, we developed SPACE (Silica Particle Assisted Chromatin Enrichment) to isolate global and regional chromatin components with high specificity and sensitivity, and SPACEmap to identify the chromatin-contact regions in proteins. Applied to mouse embryonic stem cells, SPACE identified 1459 chromatin-associated proteins, ∼48% of which are annotated as RBPs, indicating their dual roles in chromatin and RNA-binding. Additionally, SPACEmap stringently verified chromatin-binding of 403 RBPs and identified their chromatin-contact regions. Notably, SPACEmap showed that about 40% of the caRBPs bind chromatin by intrinsically disordered regions (IDRs). Studying SPACE and total proteome dynamics from mES cells grown in 2iL and serum medium indicates significant correlation (R = 0.62). One of the most dynamic caRBPs is Dazl, which we find co-localized with PRC2 at transcription start sites of genes that are distinct from Dazl mRNA binding. Dazl and other PRC2-colocalised caRBPs are rich in intrinsically disordered regions (IDRs), which could contribute to the formation and regulation of phase-separated PRC condensates. Together, our approach provides an unprecedented insight into IDR-mediated interactions and caRBPs with moonlighting functions in native chromatin