25 research outputs found

    Variation in the inter-service intervals of UK dairy cows

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    An understanding of the normal estrous cycle length of the cow is important when managing and monitoring dairy herd fertility. Whilst the normal inter-ovulatory interval is widely considered to be 21 days, some studies have found alternative intervals to be more prevalent; previously most of the variation in interval length was expected to be between cows. The aim of this study was to assess the time between inseminations (inter-service interval, ISI), in a large number of dairy cows and to explore possible associations between cow factors and estrous cycle length. The study used ISI data from 42,252 cows in 159 herds across England and Wales. Univariate analysis of the subset of 114,572 intervals between 15 and 30 days (a range covering the increased frequency of ISIs occurring at the expected time of the first return to estrus) following an insemination revealed a modal ISI of 22 days. Primiparous heifers had a modal ISI of 21 days. There were significant differences between the distribution of ISIs for different yield groups, parity numbers and the number of inseminations. Multilevel regression modelling was used to evaluate the associations between cow factors and ISI, whilst accounting for clustering at the herd and cow level. This revealed significant associations between predicted ISI and insemination number, days in milk, lactation 305 day milk yield, and month and year of insemination. Variance partition coefficients indicated that only 1% of variation in ISIs was at the herd level, 12% at the animal level and 87% at the insemination level, indicating that cycle length varies substantially more between cycles within a cow than between cows or herds. These findings suggest the “normal” range of ISI for modern UK dairy cows is longer than expected and that there is a large amount of unexplained variation in cycle length within individual animals over time

    The contribution of previous lameness events and body condition score to the occurrence of lameness in dairy herds: a study of 2 herds

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    It has been demonstrated that low body condition and previous occurrence of lameness increase the risk of future lameness in dairy cows. To date the population attributable fraction (PAF), which provides an estimate of the contribution that a risk factor makes toward the total number of disease events in a population, has not been explored for lameness using longitudinal data with repeated measures. Estimation of PAF helps to identify control measures that could lead to the largest improvements on-farm. The aim of this study was to use longitudinal data to evaluate the proportion of lameness that could be avoided in 2 separate herds (2 populations) through (1) reduced recurrence of previous lameness events, (2) and moving body condition score (BCS) into more optimal ranges. Data were obtained from 2 UK dairy herds: herd A, a 200-cow herd with 8 yr of data from a total of 724 cows where lameness events were based on weekly locomotion scores (LS; 1 to 5 scale), and herd B, a 600-cow herd with data recorded over 44 mo from a total of 1,040 cows where treatment of clinical cases was used to identify lameness events. The PAF for categories of BCS were estimated using a closed equation appropriate for multiple exposure categories. Simulation models were used to explore theoretical scenarios to reflect changes in BCS and recurrence of previous lameness events in each herd. For herd A, 21.5% of the total risk periods (cow-weeks) contained a lameness event (LS 3, 4, or 5), 96% of which were repeat events and 19% were recorded with BCS 16 wk before a risk period. The median PAF estimated for changes in BCS were in the region of 4 to 11%, depending on severity of lameness. Repeated bouts of lameness made a very large contribution to the total number of lameness events. This could either be because certain cows are initially susceptible and remain susceptible, due to the increased risk associated with previous lameness events, or due to interactions with environmental factors. This area requires further research

    HALOTHANE SOLUBILITY IN HUMAN BLOOD

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    Caudal analgesia with buprenorphine for postoperative pain relief in children

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    Caudal buprenorphine was investigated as a postoperative analgesic in a randomized double blind study in thirty children aged 5-12 years undergoing lower abdominal and lower limb surgery. Comparison was made between two groups of patients, one group receiving plain bupivacaine and the other a combination of plain bupivacaine with buprenorphine. Postoperative analgesia was assessed using a linear analogue scale, and by the response to direct questioning of children using an illustration of sequence of faces. Any untoward side effects and the need for additional analgesics were recorded. The degree and duration of analgesia was far superior in the buprenorphine group and there was a highly significant difference in the requirement of postoperative analgesia between the two groups. There were no major adverse side effects and no motor weakness in either groups, however the incidence of nausea and vomiting was higher in the buprenorphine group. It is concluded that a combination of bupivacaine with buprenorphine administered through the caudal epidural space is a safe and reliable means of providing postoperative pain relief in children for up to 24 h
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