PARTICULARITIES OF CAREER IMPROVEMENT IN A KNOWLEDGE-BASED ECONOMY AND INVESTMENT PROGRAMS FOR LIFELONG LEARNING

The concept of career planning comes nowadays along with the lifelong learning concept, which means investing in people’s potential and knowledge, supporting innovation and acquiring as many quality knowledge as possible by attending educational and learning programs. The most important investments that are made are in the human resources and the biggest profits come from the human capital and the experienced employees. Also, a great asset for the success companies are the persons who find themselves at the beginning of the career, but who are willing to adopt a lifelong learning strategy and to have a continuous personal and professional development. It is important to give each individual, no matter the age, gender or education, the opportunity to improve, to develop viable careers, following the requests of the labour market, having access to quality jobs in success companies, whether is inside their mother country or abroadcareer development, knowledge, lifelong learning.

Sensing the light: design of photoactivatable protein-protein interactions using the LOV2 domain

Photocontrol of protein-protein interactions is a powerful tool for precise spatial and temporal control of cell signaling networks. This dissertation has sought to expand the use of naturally occurring, light-sensitive proteins to photocontrol protein-protein interactions. This method allows for genetically encoded, reversible photoacitvation, or caging, of critical protein-protein interactions in a signaling network cascade. The small, globular GTPase protein Rac1 was caged through the use of the light-sensitive LOV2 domain as steric block to Rac1 effector binding in the dark. The resulting photoswitch which was created, PA-Rac, was able to induce membrane rufflng, protrusions, and directed cell movement upon blue light irradiation at the leading edge of mammalian cells. Its use has resulted in deeper understanding of the role of Rac1 in mammalian cell motility. Modeling and characterization of PA-Rac enabled caging of the related GTPase Cdc42 in a similar manner. The LOV2 domain was also used to create a photoactivatable peptide, LOV-ipaA. The photoswitch, which binds the adhesion protein vinculin, was designed by embedding a peptide sequence by into the J[alpha] helix of the LOV2 domain. As a model case, LOV-ipaA demonstrated the ability to alter the sequence of the LOV2 domain J[alpha] helix while maintaining its photoswitching capacity in order to introduce new functionality into the helix. LOV-ipaA light activated heterodimerization to vinculin was used as tool for light-induced protein expression in S. cerevisiae. This tool allowed for photoactivatable overexpression of the proteins Ste4 and Gpa1, which are critical components in regulation of the yeast pheromone mating response pathway. Through this work, signicant progress was achieved toward being able to photactivate two classes of proteins, and using those proteins as tools to manipulate biological systems

Simultaneous analyses for simultaneous present

"Simultaneous" uses of the present tense pose a challenge for the position that present tense is essentially indexical. Two kinds of accounts have been given that stay close to this position: on the Tense Deletion account, present tense can get converted into a simple bound variable over times; on the Shifting Indexical account, present tense interacts with a context variable that can get bound below a character-selecting operator. We argue that in fact both of these mechanisms are needed. We specifically argue that a Shifting Indexical approach is useful in accounting for cross-linguistic variation in the use of simultaneous present; our arguments are based on a comparison of English and Romanian data. We suggest moreover that the Romanian data have important consequences for what a Shifting Indexical analysis of present tense should look like

Violent Conflict, Environmental Degradation, and Food Security

Research project funded in academic years 2006-07, 2007-08, and 2008-09The University Archives has determined that this item is of continuing value to OSU's history.This project is a multi-pronged effort into understanding the interplay of violent conflict, food insecurity, and environmental degradation. It will examine the effects of conflict on child malnutrition, the relationship between environmental degradation and food security using data from 71 developing countries, and the relationship between child trafficking, armed conflict, and child hunger.Mershon Center for International Security StudiesProject summar

How adults and children interpret disjunction under negation in Dutch, French, Hungarian and Italian:A cross-linguistic comparison

In English, a sentence like “The cat didn’t eat the carrot or the pepper” typically receives a “neither” interpretation; in Japanese it receives a “not this or not that” interpretation. These two interpretations are in a subset/superset relation, such that the “neither” interpretation (strong reading) asymmetrically entails the “not this or not that” interpretation (weak reading). This asymmetrical entailment raises a learnability problem. According to the Semantic Subset Principle, all language learners, regardless of the language they are exposed to, start by assigning the strong reading, since this interpretation makes such sentences true in the narrowest range of circumstances.). If the “neither” interpretation is children’s initial hypothesis, then children acquiring a superset language will be able to revise their initial hypothesis on the basis of positive evidence. The aim of the present study is to test an additional account proposed by Pagliarini, Crain, Guasti (2018) as a possible explanation for the earlier convergence to the adult grammar by Italian children. The hypothesis tested here is that the presence of a lexical form such as recursive né that unambiguously conveys a “neither” meaning, would lead children to converge earlier to the adult grammar due to a blocking e!ect of the recursive né form in the inventory of negated disjunction forms in a language. We compared data from Italian (taken from Pagliarini, Crain, Guasti, 2018), French, Hungarian and Dutch. Dutch was tested as baseline language. French and Hungarian have – similarly to Italian – a lexical form that unambiguously expresses the “neither” interpretation (ni ni and sem sem, respectively). Our results did not support this hypothesis however, and are discussed in the light of language-specifc particularities of the syntax and semantics of negation